{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:58:31Z","timestamp":1792706311116,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jaci.2016.03.023","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T16:15:15Z","timestamp":1465402515000},"page":"258-268.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Allergen endotoxins induce T-cell\u2013dependent and non\u2013IgE-mediated nasal hypersensitivity in mice"],"prefix":"10.1016","volume":"139","author":[{"given":"Naruhito","family":"Iwasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakiyo","family":"Nakahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Akasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koubun","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.03.023_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S1471-4906(03)00142-X","article-title":"The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation","volume":"24","author":"Rajan","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2016.03.023_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2011.01.019","article-title":"Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms","volume":"127","author":"Nomura","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2016.03.023_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/all.12358","article-title":"The multiple factors affecting the association between atopic dermatitis and contact sensitization","volume":"69","author":"Thyssen","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.023_bib6","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2008.06.003","article-title":"The diagnosis and management of rhinitis: an updated practice parameter","volume":"122","author":"Wallace","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1398-9995.2008.01846.x","article-title":"Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis","volume":"64","author":"Humbert","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.023_bib8","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaci.2003.09.015","article-title":"Allergic rhinitis: systemic inflammation and implications for management","volume":"112","author":"Borish","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib9","doi-asserted-by":"crossref","first-page":"e103540","DOI":"10.1371\/journal.pone.0103540","article-title":"Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice","volume":"9","author":"Kato","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.03.023_bib10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/cea.12476","article-title":"Local IgE in non-allergic rhinitis","volume":"45","author":"Campo","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.03.023_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/ACI.0b013e3283630cd8","article-title":"Nonallergic rhinitis: therapeutic options","volume":"13","author":"Bernstein","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4193\/Rhino13.102","article-title":"Role of inflammation in non-allergic rhinitis","volume":"52","author":"de Corso","year":"2014","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2016.03.023_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/039463200802100209","article-title":"Non-allergic rhinitis with eosinophils and mast cells constitutes a new severe nasal disorder","volume":"21","author":"Gelardi","year":"2008","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jaci.2016.03.023_bib14","first-page":"73","article-title":"Quality of life in non-allergic rhinitis depends on the predominant inflammatory cell type","volume":"22","author":"Gelardi","year":"2008","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.jaci.2016.03.023_bib15","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00405-015-3769-4","article-title":"Non-allergic rhinitis with eosinophilia syndrome is not associated with local production of specific IgE in nasal mucosa","volume":"273","author":"Becker","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2016.03.023_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib17","doi-asserted-by":"crossref","first-page":"778","DOI":"10.4049\/jimmunol.156.2.778","article-title":"Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages","volume":"156","author":"Takamatsu","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2011.08.002","article-title":"TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism","volume":"141","author":"Smuda","year":"2011","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2016.03.023_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s000110050438","article-title":"Regulation of histamine synthesis in mouse CD4+ and CD8+ T lymphocytes","volume":"48","author":"Kubo","year":"1999","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jaci.2016.03.023_bib20","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.2928797","article-title":"Histamine is an intracellular messenger mediating platelet aggregation","volume":"243","author":"Saxena","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.03.023_bib21","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/bjd.13199","article-title":"The histamine-synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin","volume":"171","author":"Gutowska-Owsiak","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2016.03.023_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00011-007-7049-7","article-title":"Elevated CREB activity in embryonic fibroblasts of gene-targeted histamine deficient mice","volume":"56","author":"Hegyi","year":"2007","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jaci.2016.03.023_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.03.023_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jaci.2005.05.015","article-title":"Infant home\u00a0endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhood","volume":"116","author":"Abraham","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib25","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jaci.2012.01.051","article-title":"House dust bioactivities predict skin prick test reactivity for children with high risk of allergy","volume":"129","author":"Kim","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2466-11-12","article-title":"Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: a randomized laboratory study","volume":"11","author":"Natarajan","year":"2011","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2016.03.023_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4168\/aair.2013.5.2.102","article-title":"Preparation and characterization of an extract of German cockroach from a Korean source","volume":"5","author":"Jeong","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2016.03.023_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.taap.2005.01.023","article-title":"Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies","volume":"207","author":"Becker","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jaci.2016.03.023_bib29","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1172\/JCI39717","article-title":"Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice","volume":"119","author":"Bedoret","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2016.03.023_bib30","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/eji.201142123","article-title":"DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation","volume":"42","author":"Zhang","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib31","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.4049\/jimmunol.0901039","article-title":"Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in\u00a0vivo","volume":"183","author":"Kamijo","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib32","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jaci.2011.06.041","article-title":"Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin\/OX40 ligand\/OX40 signaling pathways","volume":"128","author":"Li","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib33","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4049\/jimmunol.1300284","article-title":"Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands","volume":"191","author":"Herre","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib34","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1172\/JCI0214704","article-title":"Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity","volume":"109","author":"Supajatura","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2016.03.023_bib35","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.179.7.4415","article-title":"IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation","volume":"179","author":"Yoshimoto","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib36","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.1401768","article-title":"B cell-intrinsic MyD88 signaling is essential for\u00a0IgE\u00a0responses in lungs exposed to pollen allergens","volume":"193","author":"Matsushita","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/intimm\/dxv055","article-title":"Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways","volume":"28","author":"Akasaki","year":"2016","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/intimm\/dxv050","article-title":"Group 2 innate lymphoid cells in disease","volume":"28","author":"Halim","year":"2016","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib39","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.4049\/jimmunol.1101746","article-title":"Role\u00a0of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness","volume":"188","author":"Sawaguchi","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib40","first-page":"142","article-title":"Nasal provocation test (NPT) with isolated and associated dermatophagoides pteronyssinus (Dp) and endotoxin lipopolysaccharide (LPS) in children with allergic rhinitis (AR) and nonallergic controls","volume":"14","author":"Braga","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s004050000285","article-title":"Lipopolysaccharide-induced nasal cytokine response: a dose-response evaluation","volume":"257","author":"Danuser","year":"2000","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2016.03.023_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/00016480600801340","article-title":"Lipopolysaccharide-induced down-regulation of uteroglobin in the human nose","volume":"127","author":"Fransson","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaci.2016.03.023_bib43","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1365-2222.2009.03374.x","article-title":"Histamine, histamine receptors and their role in immune pathology","volume":"39","author":"Jutel","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.03.023_bib44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1365-2222.2007.02705.x","article-title":"Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase","volume":"37","author":"Sato","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.03.023_bib45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"Varol","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.03.023_bib46","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature11930","article-title":"Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages","volume":"495","author":"Satoh","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2016.03.023_bib47","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"Jenkins","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.03.023_bibE1","doi-asserted-by":"crossref","first-page":"e103540","DOI":"10.1371\/journal.pone.0103540","article-title":"Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice","volume":"9","author":"Kato","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.03.023_bibE2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/intimm\/dxv055","article-title":"Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways","volume":"28","author":"Akasaki","year":"2016","journal-title":"Int Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916301464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916301464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:01:11Z","timestamp":1758790871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916301464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0091674916301464"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.023","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allergen endotoxins induce T-cell\u2013dependent and non\u2013IgE-mediated nasal hypersensitivity in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}