{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:53:27Z","timestamp":1778039607447,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jaci.2016.03.040","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T12:51:44Z","timestamp":1462625504000},"page":"893-895.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The quest for autoreactive antibodies in nasal polyps"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-1900","authenticated-orcid":false,"given":"Els","family":"De Schryver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lien","family":"Calus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Bonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De Ruyck","family":"Natalie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Elewaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mittermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gutermuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Seher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Schleimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Derycke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaut","family":"Van Zele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.03.040_bib1","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1111\/j.1365-2222.2007.02838.x","article-title":"Local immunoglobulin production in nasal polyposis is modulated by superantigens","volume":"37","author":"Van Zele","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.03.040_bib2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jaci.2013.01.043","article-title":"Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression","volume":"131","author":"Hulse","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/all.12054","article-title":"Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps","volume":"68","author":"Gevaert","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.040_bib4","first-page":"163","article-title":"Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis","volume":"20","author":"Bachert","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/039463201002300228","article-title":"Autologous serum skin test reactivity and basophil histamine release test in patients with nasal polyposis: preliminary results","volume":"23","author":"Zambetti","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jaci.2016.03.040_bib6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2011.08.037","article-title":"Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps","volume":"128","author":"Tan","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib7","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1398-9995.2009.02132.x","article-title":"EAACI\/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria","volume":"64","author":"Konstantinou","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.040_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-3083.1993.tb01744.x","article-title":"Antibodies to dsDNA are produced during primary BK virus infection in man, indicating that anti-dsDNA antibodies may be related to virus replication in\u00a0vivo","volume":"38","author":"Fredriksen","year":"1993","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0049-0172(98)80047-4","article-title":"Autoantibodies and common viral illnesses","volume":"27","author":"Hansen","year":"1998","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jaci.2016.03.040_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/08916930500484849","article-title":"Epstein-Barr virus and molecular\u00a0mimicry in systemic lupus erythematosus","volume":"39","author":"Poole","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaci.2016.03.040_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02686087","article-title":"Molecular mimicry and auto-immunity","volume":"32","author":"Blank","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib12","first-page":"557","article-title":"High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population","volume":"69","author":"Manoussakis","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bib13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.jaci.2014.06.029","article-title":"\u201cAuto-anti-IgE\u201d: naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation","volume":"134","author":"Chan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bibE1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2016.03.040_bibE2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/000348949510410s02","article-title":"Quantification for staging sinusitis. The Staging and Therapy Group","volume":"167","author":"Lund","year":"1995","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"10.1016\/j.jaci.2016.03.040_bibE3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1034\/j.1398-9995.2003.00110.x","article-title":"Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis","volume":"58","author":"Gevaert","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.040_bibE4","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1398-9995.2009.02132.x","article-title":"EAACI\/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria","volume":"64","author":"Konstantinou","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.03.040_bibE5","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.jaci.2014.06.029","article-title":"\u201cAuto-anti-IgE\u201d: naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation","volume":"134","author":"Chan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bibE6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0003-2697(86)90228-9","article-title":"Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea","volume":"155","author":"Fling","year":"1986","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jaci.2016.03.040_bibE7","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2016.03.040_bibE8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000024228","article-title":"Characterization of IgE-reactive autoantigens in atopic dermatitis. 1. Subcellular distribution and tissue-specific expression","volume":"120","author":"Seiberler","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.03.040_bibE9","first-page":"971","article-title":"Validation of a new screening strategy for anti-extractable nuclear antigen antibodies","volume":"27","author":"Van Praet","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaci.2016.03.040_bibE10","first-page":"205","article-title":"Multicenter validation of recombinant, natural and synthetic antigens used in\u00a0a\u00a0single multiparameter assay for the detection of specific anti-nuclear autoantibodies in connective tissue disorders","volume":"17","author":"Meheus","year":"1999","journal-title":"Clin Exp Rheumatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916302597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916302597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:03:39Z","timestamp":1758791019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916302597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0091674916302597"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.040","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The quest for autoreactive antibodies in nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}