{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:30Z","timestamp":1791274470607,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jaci.2016.03.049","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T21:17:28Z","timestamp":1462915048000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":240,"title":["Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence"],"prefix":"10.1016","volume":"139","author":[{"given":"Frederick J.","family":"Rubner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Gangnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Tisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tressa E.","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.03.049_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.iac.2010.08.004","article-title":"The role of respiratory infections in childhood asthma inception","volume":"30","author":"Jackson","year":"2010","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2016.03.049_bib2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2005.01.057","article-title":"Effects of viral respiratory infections on lung development and childhood asthma","volume":"115","author":"Gern","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jaci.2004.08.031","article-title":"Viral infections and asthma inception","volume":"114","author":"Lemanske","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(08)61451-8","article-title":"Early identification of atopy in the prediction of persistent asthma in children","volume":"372","author":"Sly","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.03.049_bib5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1067\/mai.2003.162","article-title":"Tucson children's respiratory study: 1980 to present","volume":"111","author":"Taussig","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2010.07.011","article-title":"Long-term studies of the natural history of asthma in childhood","volume":"126","author":"Bisgaard","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.03.049_bib9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/thx.2009.121582","article-title":"Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life","volume":"65","author":"Sigurs","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.03.049_bib10","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","article-title":"Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7","volume":"161","author":"Sigurs","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jmv.1890400204","article-title":"Improved detection of rhinoviruses in nasal and throat swabs by seminested RT-PCR","volume":"40","author":"Ireland","year":"1993","journal-title":"J Med Virol"},{"key":"10.1016\/j.jaci.2016.03.049_bib12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.201104-0660OC","article-title":"Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life","volume":"185","author":"Jackson","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib15","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJMoa1211592","article-title":"Rhinovirus wheezing illness and genetic risk of childhood onset asthma","volume":"368","author":"Caliskan","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cea.12050","article-title":"Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk","volume":"43","author":"Stoltz","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.03.049_bib17","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200907-1101OC","article-title":"Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study","volume":"181","author":"Simpson","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1399-3038.13.s.15.8.x","article-title":"The childhood origins of asthma (COAST) study","volume":"13","author":"Lemanske","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","article-title":"Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy","volume":"13","author":"Gern","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0091-6749(03)01868-2","article-title":"Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life","volume":"112","author":"Neaville","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1183\/09031936.00161907","article-title":"Serial viral infections in infants with recurrent respiratory illnesses","volume":"32","author":"Jartti","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.03.049_bib22","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1128\/JCM.02501-06","article-title":"High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses","volume":"45","author":"Lee","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaci.2016.03.049_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib24","series-title":"Flexible imputation of missing data","author":"van Buuren","year":"2012"},{"key":"10.1016\/j.jaci.2016.03.049_bib25","series-title":"Multiple imputation for nonresponse in surveys","author":"Rubin","year":"1987"},{"key":"10.1016\/j.jaci.2016.03.049_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.03.049_bib27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jaci.2012.05.023","article-title":"Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children","volume":"130","author":"Durrani","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib28","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.0901194","article-title":"Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells","volume":"184","author":"Gill","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.03.049_bib29","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jaci.2011.11.046","article-title":"Recurrent severe exacerbations in early life and reduced lung function at school age","volume":"129","author":"O\u2019Brian","year":"2012","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916302767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916302767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:02:58Z","timestamp":1758790978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916302767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0091674916302767"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.049","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.03.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}