{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:36:04Z","timestamp":1788262564331,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jaci.2016.04.028","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T19:13:18Z","timestamp":1465067598000},"page":"977-983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Do we really need asthma\u2013chronic obstructive pulmonary disease overlap syndrome?"],"prefix":"10.1016","volume":"138","author":[{"given":"Mario","family":"Cazzola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rogliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.04.028_bib1","series-title":"Bronchitis","first-page":"43","article-title":"The host factor in bronchitis","author":"Orie","year":"1961"},{"key":"10.1016\/j.jaci.2016.04.028_bib2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1183\/09031936.93.04040490","article-title":"\u201cSplitting\u201d look at chronic nonspecific lung disease (CNSLD): common features but diverse pathogenesis","volume":"4","author":"Vermeire","year":"1991","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.04.028_bib3","unstructured":"Global Initiative for COLD. Joint project of GOLD and GINA 2014. Global strategy for asthma management and prevention 2014. Diagnosis of diseases of chronic airflow limitation: asthma, COPD and asthma-COPD overlap syndrome (ACOS). Global Initiative for Asthma, Global Initiative for Chronic Obstructive Lung Disease. Available at: http:\/\/www.ginasthma.org and http:\/\/www.goldcopd.org. Accessed March 20, 2016."},{"key":"10.1016\/j.jaci.2016.04.028_bib4","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1056\/NEJMra1411863","article-title":"The Asthma-COPD overlap syndrome","volume":"373","author":"Postma","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1753465815617082","article-title":"Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?","volume":"10","author":"Slats","year":"2016","journal-title":"Ther Adv Respir Dis"},{"key":"10.1016\/j.jaci.2016.04.028_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1378\/chest.15-1055","article-title":"Defining the Asthma-COPD overlap syndrome in a COPD cohort","volume":"149","author":"Cosio","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2016.04.028_bib7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jaci.2010.01.003","article-title":"Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up","volume":"125","author":"Contoli","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.04.028_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/15412555.2011.611200","article-title":"Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population","volume":"8","author":"Diaz-Guzman","year":"2011","journal-title":"COPD"},{"key":"10.1016\/j.jaci.2016.04.028_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/02770903.2011.555576","article-title":"Overlap syndrome of asthma and COPD predicts low quality of life","volume":"48","author":"Kauppi","year":"2011","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2016.04.028_bib10","first-page":"795","article-title":"Characteristics and self-rated health of overlap syndrome","volume":"9","author":"Chung","year":"2014","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jaci.2016.04.028_bib11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.rmed.2013.03.007","article-title":"Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status","volume":"107","author":"Miravitlles","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib12","first-page":"283","article-title":"Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma","volume":"7","author":"Kitaguchi","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jaci.2016.04.028_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1465-9921-12-127","article-title":"The\u00a0clinical\u00a0features of the overlap between COPD and asthma","volume":"12","author":"Hardin","year":"2011","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2016.04.028_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1183\/09031936.00216013","article-title":"The clinical and genetic features of COPD-asthma overlap syndrome","volume":"44","author":"Hardin","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.04.028_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1378\/chest.13-0622","article-title":"Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma","volume":"145","author":"Menezes","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2016.04.028_bib16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1053\/rmed.2003.1491","article-title":"Airway inflammation in asthma with incomplete reversibility of airflow obstruction","volume":"97","author":"Boulet","year":"2003","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1183\/09031936.04.00077803","article-title":"Parameters associated with persistent airflow obstruction in chronic severe asthma","volume":"24","author":"Bumbacea","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.04.028_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.rmed.2007.08.003","article-title":"Improvements with tiotropium in COPD patients with concomitant asthma","volume":"102","author":"Magnussen","year":"2008","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000352053","article-title":"Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome","volume":"87","author":"Fu","year":"2014","journal-title":"Respiration"},{"key":"10.1016\/j.jaci.2016.04.028_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1183\/09031936.00024313","article-title":"Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap","volume":"43","author":"Iwamoto","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.04.028_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1164\/rccm.200603-381OC","article-title":"Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm","volume":"175","author":"De Marco","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.rmed.2013.01.001","article-title":"Prevalence and characteristics of three clinical phenotypes of chronic obstructive pulmonary disease (COPD)","volume":"107","author":"Izquierdo-Alonso","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/thx.2008.108027","article-title":"The overlap syndrome of asthma and COPD: what are its features and how important is it?","volume":"64","author":"Gibson","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.04.028_bib24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S2213-2600(13)70086-9","article-title":"A lbert P, Walker PP. Bronchodilator reversibility in chronic obstructive pulmonary disease: use and limitations","volume":"1","author":"Calverley","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.rmed.2010.09.022","article-title":"The prevalence of asthma and COPD in Italy: a practice-based study","volume":"105","author":"Cazzola","year":"2011","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.arbres.2015.07.005","article-title":"Mixed COPD-asthma phenotype: ACOS or CAOS? A\u00a0reflection on recent guidelines and recommendations","volume":"52","author":"Fern\u00e1ndez-Villar","year":"2016","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.jaci.2016.04.028_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/thoraxjnl-2014-206740","article-title":"Asthma\u2013COPD overlap 2015: now we are six","volume":"70","author":"Gibson","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.04.028_bib28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/thx.2007.089193","article-title":"Proportional classifications of COPD phenotypes","volume":"63","author":"Marsh","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.04.028_bib29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.arbres.2013.12.013","article-title":"Distribution of clinical phenotypes in patients with chronic obstructive pulmonary disease caused by biomass and tobacco smoke","volume":"50","author":"Golpe","year":"2014","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.jaci.2016.04.028_bib30","doi-asserted-by":"crossref","first-page":"e62985","DOI":"10.1371\/journal.pone.0062985","article-title":"The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population","volume":"8","author":"de Marco","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.04.028_bib31","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.rmed.2014.05.016","article-title":"Asthma control in elderly asthmatics. An Italian observational study","volume":"108","author":"Milanese","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib32","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/resp.12653","article-title":"Asthma-COPD overlap syndrome (ACOS): a diagnostic challenge","volume":"21","author":"Tho","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.jaci.2016.04.028_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2015.10.004","article-title":"Understanding asthma-chronic obstructive pulmonary disease overlap syndrome","volume":"110","author":"Wurst","year":"2016","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib34","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jaci.2015.06.043","article-title":"Treatment of overlapping asthma-chronic obstructive pulmonary disease: Can guidelines contribute in an evidence-free zone?","volume":"136","author":"Reddel","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.04.028_bib35","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1164\/rccm.200203-183OC","article-title":"Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease","volume":"167","author":"Fabbri","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00428-015-1824-6","article-title":"Old dilemma: asthma with irreversible airway obstruction or COPD","volume":"467","author":"Fattahi","year":"2015","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jaci.2016.04.028_bib37","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nm.2678","article-title":"Asthma phenotypes: the evolution from clinical to molecular approaches","volume":"18","author":"Wenzel","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib38","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s40291-014-0100-9","article-title":"Defining phenotypes in COPD: an aid to personalized healthcare","volume":"18","author":"Segreti","year":"2014","journal-title":"Mol Diagn Ther"},{"key":"10.1016\/j.jaci.2016.04.028_bib39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1183\/13993003.01359-2015","article-title":"Treatable traits: toward precision medicine of chronic airway diseases","volume":"47","author":"Agusti","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.04.028_bib40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S2213-2600(15)00254-4","article-title":"The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?","volume":"3","author":"Bateman","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib41","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.rmed.2014.03.002","article-title":"Understanding the GOLD 2011 Strategy as applied to a real-world COPD population","volume":"108","author":"Vestbo","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.04.028_bib42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000315416","article-title":"Inhaled corticosteroids in COPD: a controversy","volume":"80","author":"Barnes","year":"2010","journal-title":"Respiration"},{"key":"10.1016\/j.jaci.2016.04.028_bib43","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jaip.2014.11.003","article-title":"Is it asthma or is it COPD: The overlap syndrome","volume":"3","author":"Bell","year":"2015","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916303682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916303682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:01:22Z","timestamp":1758790882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916303682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0091674916303682"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.04.028","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do we really need asthma\u2013chronic obstructive pulmonary disease overlap syndrome?","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}