{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:29:07Z","timestamp":1791311347503,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jaci.2016.06.032","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T17:15:45Z","timestamp":1469726145000},"page":"964-976.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production"],"prefix":"10.1016","volume":"139","author":[{"given":"Laura","family":"Maggi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Montaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Rossettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Santarlasci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cosmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Romagnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Annunziato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.06.032_bib1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1067\/mai.2001.114989","article-title":"The other side of the coin: the protective role of the TH2 cytokines","volume":"107","author":"Finkelman","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1067\/mai.2000.104575","article-title":"The role of lymphocytes in allergic disease","volume":"105","author":"Romagnani","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1067\/mai.2003.169","article-title":"The role of T lymphocytes in the pathogenesis of asthma","volume":"111","author":"Larch\u00e8","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib5","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.4049\/jimmunol.171.7.3655","article-title":"Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair","volume":"171","author":"Sandler","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib6","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jaci.2013.05.012","article-title":"IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction","volume":"132","author":"Barlow","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2015.06.021","article-title":"An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers","volume":"43","author":"Morita","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.06.032_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.coi.2013.02.010","article-title":"Development and function of group 2 innate lymphoid cells","volume":"25","author":"Walker","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev-immunol-020711-075053","article-title":"Innate lymphoid cells: emerging insights in development, lineage relationships, and function","volume":"30","author":"Spits","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jaci.2014.02.015","article-title":"Innate lymphoid cells and asthma","volume":"133","author":"Yu","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"Fallon","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.06.032_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.coi.2013.07.013","article-title":"Innate lymphoid cells and allergic inflammation","volume":"25","author":"Kim","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2016.06.032_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaci.2013.03.048","article-title":"Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production","volume":"132","author":"Doherty","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mjosberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2012.08.015","article-title":"The transcriptional factor GATA3 is essential for the function of human type 2 innate lymphoid cells","volume":"37","author":"Mjosberg","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.06.032_bib17","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204","author":"Annunziato","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.06.032_bib18","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.4049\/jimmunol.1401303","article-title":"Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells","volume":"194","author":"Mazzoni","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2105-11-230","article-title":"BISMA\u2014fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences","volume":"11","author":"Rohde","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2016.06.032_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ni.3078","article-title":"IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential \u2018inflammatory\u2019 type 2 innate lymphoid cells","volume":"16","author":"Huang","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni.2830","article-title":"Innate\u00a0lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells","volume":"15","author":"Magri","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1189\/jlb.3BT0814-383R","article-title":"At the bedside: the emergence of group 2 innate lymphoid cells in human disease","volume":"97","author":"Peebles","year":"2015","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2016.06.032_bib23","doi-asserted-by":"crossref","first-page":"174ra26","DOI":"10.1126\/scitranslmed.3004812","article-title":"Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma","volume":"5","author":"Barnig","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2016.06.032_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clim.2014.09.007","article-title":"Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness","volume":"155","author":"Walford","year":"2014","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib25","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/all.12440","article-title":"Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis","volume":"69","author":"Miljikovic","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.06.032_bib26","doi-asserted-by":"crossref","first-page":"170ra16","DOI":"10.1126\/scitranslmed.3005374","article-title":"TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation","volume":"5","author":"Kim","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2016.06.032_bib27","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A\u00a0role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"Salimi","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.06.032_bib28","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/jid.2014.146","article-title":"Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+)ILC3 in lesional skin and blood of psoriasis patients","volume":"134","author":"Teunissen","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.032_bib29","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.8178175","article-title":"Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations","volume":"264","author":"Marsh","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.06.032_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaci.2015.05.037","article-title":"Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia","volume":"137","author":"Smith","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jaci.2015.06.038","article-title":"Type 2 innate lymphoid cells in induced sputum from children with severe asthma","volume":"137","author":"Nagakumar","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.032_bib32","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.06.032_bib33","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630714X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630714X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:05:51Z","timestamp":1758791151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491630714X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S009167491630714X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.06.032","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}