{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:23Z","timestamp":1790179163820,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jaci.2016.06.034","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T01:07:33Z","timestamp":1469840853000},"page":"997-1006.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Defective natural killer cell activity in a mouse model of eczema herpeticum"],"prefix":"10.1016","volume":"139","author":[{"given":"Yuko","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Rok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisen","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Nakasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manando","family":"Nakasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Soo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.06.034_bib1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.06.034_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic dermatitis: a disease of altered skin barrier and immune dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2016.06.034_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1067\/mai.2002.128052","article-title":"Smallpox vaccination: risk considerations for patients with atopic dermatitis","volume":"110","author":"Engler","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib4","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.jid.5700657","article-title":"Risk factors of atopic dermatitis patients for eczema herpeticum","volume":"127","author":"Peng","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/S0190-9622(03)00896-X","article-title":"Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases","volume":"49","author":"Wollenberg","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib6","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1017\/S1462399408000756","article-title":"Molecular pathogenesis and clinical implications of eczema herpeticum","volume":"10","author":"Bussmann","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.jaci.2016.06.034_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jaci.2009.05.020","article-title":"Phenotype of atopic dermatitis subjects with a history of eczema herpeticum","volume":"124","author":"Beck","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4049\/jimmunol.1300102","article-title":"Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions","volume":"192","author":"Takahashi","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib9","doi-asserted-by":"crossref","first-page":"7736","DOI":"10.4049\/jimmunol.176.12.7736","article-title":"NK cells and gamma delta+ T cells are phenotypically and functionally defective due to preferential apoptosis in patients with atopic dermatitis","volume":"176","author":"Katsuta","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.coi.2009.09.006","article-title":"Mast cells in atopic dermatitis","volume":"21","author":"Kawakami","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib12","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1172\/JCI1647","article-title":"Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice","volume":"101","author":"Spergel","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2016.06.034_bib13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2332\/allergolint.O-07-486","article-title":"An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of tec family kinases","volume":"56","author":"Kawakami","year":"2007","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2016.06.034_bib14","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1084\/jem.20082835","article-title":"Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum","volume":"206","author":"Kawakami","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.06.034_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3851\/IMP1717","article-title":"Protective murine and human monoclonal antibodies against eczema vaccinatum","volume":"16","author":"Tomimori","year":"2011","journal-title":"Antivir Ther"},{"key":"10.1016\/j.jaci.2016.06.034_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/iai.40.1.103-112.1983","article-title":"Comparative neurovirulence of herpes simplex virus type 1 strains after peripheral or intracerebral inoculation of BALB\/c mice","volume":"40","author":"Dix","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2016.06.034_bib17","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1128\/JVI.72.9.7563-7568.1998","article-title":"Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid","volume":"72","author":"Desai","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2016.06.034_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2180-10-163","article-title":"Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs","volume":"10","author":"Brans","year":"2010","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jaci.2016.06.034_bib19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1743-422X-6-56","article-title":"A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages","volume":"6","author":"Mott","year":"2009","journal-title":"Virol J"},{"key":"10.1016\/j.jaci.2016.06.034_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib21","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/jid.2013.250","article-title":"Mast Cells Are Required for Full Expression of Allergen\/SEB-Induced Skin Inflammation","volume":"133","author":"Ando","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jaci.2014.07.018","article-title":"Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum","volume":"134","author":"Bin","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri2276","article-title":"Evolutionary struggles between NK cells and viruses","volume":"8","author":"Lanier","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib24","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.it.2007.04.001","article-title":"Keeping NK cells in highly regulated antiviral warfare","volume":"28","author":"Lee","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib25","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1182\/blood-2008-10-187179","article-title":"Maturation\u00a0of\u00a0mouse\u00a0NK cells is a 4-stage developmental program","volume":"113","author":"Chiossone","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.06.034_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ni796","article-title":"In\u00a0vivo developmental stages in murine natural killer cell maturation","volume":"3","author":"Kim","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.coi.2005.01.005","article-title":"Distinguishing features of developing natural killer cells","volume":"17","author":"Vosshenrich","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/dna.2004.23.549","article-title":"Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma","volume":"23","author":"Kataoka","year":"2004","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.jaci.2016.06.034_bib29","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.4049\/jimmunol.1100370","article-title":"NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in\u00a0vivo","volume":"186","author":"Nishikado","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib30","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.4049\/jimmunol.164.4.2009","article-title":"NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells","volume":"164","author":"Slifka","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jlb.37.5.597","article-title":"Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages","volume":"37","author":"Wiltrout","year":"1985","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2016.06.034_bib32","doi-asserted-by":"crossref","first-page":"E2376","DOI":"10.1073\/pnas.1424241112","article-title":"NK cells require IL-28R for optimal in\u00a0vivo activity","volume":"112","author":"Souza-Fonseca-Guimaraes","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2016.06.034_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s13365-011-0031-8","article-title":"IL-29\/IL-28A suppress HSV-1 infection of human NT2-N neurons","volume":"17","author":"Zhou","year":"2011","journal-title":"J Neurovirol"},{"key":"10.1016\/j.jaci.2016.06.034_bib34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.20012023","article-title":"Rapid cytotoxic T\u00a0lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus","volume":"195","author":"Mueller","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.06.034_bib35","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.4049\/jimmunol.171.12.6733","article-title":"CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase","volume":"171","author":"Sloan","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib37","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.06.034_bib38","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/jid.2012.40","article-title":"Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis","volume":"132","author":"Fyhrquist","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1523-1747.ep12259055","article-title":"Modulation of natural killer cell activity in patients with atopic dermatitis","volume":"82","author":"Jensen","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.06.034_bib40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2222.1984.tb02232.x","article-title":"Natural-killer-cell activity in atopic dermatitis","volume":"14","author":"Lever","year":"1984","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaci.2016.06.034_bib41","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1099\/0022-1317-83-12-2933","article-title":"Herpes simplex virus type 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non-McKrae-like virulence","volume":"83","author":"Perng","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jaci.2016.06.034_bib42","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1128\/JVI.00646-12","article-title":"Genome sequence of herpes simplex virus 1 strain KOS","volume":"86","author":"Macdonald","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2016.06.034_bib43","doi-asserted-by":"crossref","first-page":"9540","DOI":"10.1128\/JVI.01469-12","article-title":"Genome sequence of herpes simplex virus 1 strain McKrae","volume":"86","author":"Macdonald","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2016.06.034_bib44","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib45","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.06.034_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2016.06.034_bib47","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1172\/JCI11679","article-title":"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome","volume":"106","author":"Chatila","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2016.06.034_bib48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse","volume":"27","author":"Brunkow","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2016.06.034_bib49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2340\/00015555-1882","article-title":"Regulatory T-cell subsets in atopic dermatitis: important indicators of disease severity with acquired functional impairment","volume":"95","author":"Gaspar","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2016.06.034_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1081-1206(10)60170-6","article-title":"Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis","volume":"103","author":"Ito","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib51","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaci.2004.01.772","article-title":"T regulatory cells in atopic dermatitis and subversion of their activity by superantigens","volume":"113","author":"Ou","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2007.11.003","article-title":"Analysis of CD25hiCD4+ \u201cregulatory\u201d T-cell subtypes in atopic dermatitis reveals a novel T(H)2-like population","volume":"121","author":"Reefer","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib53","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jaci.2007.05.036","article-title":"Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects","volume":"120","author":"Orihara","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.06.034_bib54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000323306","article-title":"Increased susceptibility to cutaneous viral infections in atopic dermatitis: the roles of regulatory T cells and innate immune defects","volume":"41","author":"Shiohara","year":"2011","journal-title":"Curr Probl Dermatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916307217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916307217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:06:14Z","timestamp":1758791174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916307217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0091674916307217"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.06.034","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective natural killer cell activity in a mouse model of eczema herpeticum","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}