{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:53:39Z","timestamp":1791942819523,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jaci.2016.08.009","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:38:52Z","timestamp":1473453532000},"page":"1176-1185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":176,"title":["Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations"],"prefix":"10.1016","volume":"139","author":[{"given":"Marina","family":"Pretolani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bergqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Thabut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Dombret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loubna","family":"Alavoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Taill\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Chanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas S.","family":"Erjef\u00e4lt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Aubier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.08.009_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1183\/09059180.00001913","article-title":"Severe refractory asthma: an update","volume":"22","author":"Wener","year":"2013","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jaci.2016.08.009_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MCP.0000000000000007","article-title":"Monoclonal antibodies for the treatment of refractory asthma","volume":"20","author":"Hambly","year":"2014","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.08.009_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaci.2003.10.041","article-title":"Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation","volume":"113","author":"Miranda","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.009_bib5","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nm.2678","article-title":"Asthma phenotypes: the evolution from clinical to molecular approaches","volume":"18","author":"Wenzel","year":"2012","journal-title":"Nat Med"},{"issue":"suppl","key":"10.1016\/j.jaci.2016.08.009_bib6","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1513\/AnnalsATS.201304-087AW","article-title":"How variability in clinical phenotypes should guide research into disease mechanisms in asthma","volume":"10","author":"Chung","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jaci.2016.08.009_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1183\/09031936.00168210","article-title":"Noneosinophilic asthma in children: relation with airway remodelling","volume":"38","author":"Baraldo","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.08.009_bib8","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1378\/chest.12-3073","article-title":"Mechanisms of airway remodelling","volume":"144","author":"Hirota","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2016.08.009_bib9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-2222.2011.03917.x","article-title":"Lung damage and airway remodelling in severe asthma","volume":"42","author":"Brightling","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.009_bib10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa064707","article-title":"Asthma control during the year after BT","volume":"356","author":"Cox","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib11","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/rccm.200704-571OC","article-title":"Safety and efficacy of BT in symptomatic, severe asthma","volume":"176","author":"Pavord","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1164\/rccm.200903-0354OC","article-title":"Effectiveness and safety of BT in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial","volume":"181","author":"Castro","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1164\/rccm.201105-0883CI","article-title":"BT for severe asthma","volume":"185","author":"Wahidi","year":"2012","journal-title":"Am J Respir Crit Car Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib14","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1183\/09059180.00005114","article-title":"BT: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults","volume":"134","author":"Dombret","year":"2014","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.jaci.2016.08.009_bib15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1164\/rccm.201407-1374LE","article-title":"Reduction of ASM mass by BT in patients with severe asthma","volume":"190","author":"Pretolani","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.08.009_bib17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.08.009_bib18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.rmed.2004.10.008","article-title":"Measurement properties and interpretation of three shortened versions of the asthma control questionnaire","volume":"99","author":"Juniper","year":"2005","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1164\/ajrccm\/147.4.832","article-title":"Measuring quality of life in asthma","volume":"147","author":"Juniper","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaci.2016.08.009_bib20","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1164\/rccm.200209-1030OC","article-title":"Airway structural alterations selectively associated with severe asthma","volume":"167","author":"Benayoun","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CS20140309","article-title":"Alveolar T-helper type-2 immunity in atopic asthma is associated with poor clinical control","volume":"128","author":"Bergqvist","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jaci.2016.08.009_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/thoraxjnl-2012-202879","article-title":"Appearance of remodeled and dendritic cell-rich alveolar-lymphoid interfaces provides a structural basis for increased alveolar antigen uptake in chronic obstructive pulmonary disease","volume":"68","author":"Mori","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.08.009_bib23","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1164\/rccm.201308-1444LE","article-title":"Marked epithelial cell pathology and leukocyte paucity in persistently symptomatic severe asthma","volume":"188","author":"Bergqvist","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.009_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.anai.2013.05.002","article-title":"Safety of BT in patients with severe refractory asthma. Research in Severe Asthma Trial Study Group","volume":"111","author":"Pavord","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2016.08.009_bib25","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jaci.2013.08.009","article-title":"Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma","volume":"132","author":"Wechsler","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.009_bib26","first-page":"1612","article-title":"Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma","volume":"12","author":"Chakir","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jaci.2016.08.009_bib27","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1152\/japplphysiol.01282.2003","article-title":"Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs","volume":"97","author":"Danek","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jaci.2016.08.009_bib28","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1378\/chest.127.6.1999","article-title":"A prospective feasibility study of BT in the human airway","volume":"127","author":"Miller","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2016.08.009_bib29","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.jaci.2007.01.055","article-title":"Specificity of basement membrane thickening in severe asthma","volume":"119","author":"Bourdin","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.009_bib30","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1034\/j.1399-3003.2000.01507.x","article-title":"Bronchial angiogenesis in severe glucocorticoid-dependent asthma","volume":"15","author":"Vrugt","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.08.009_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/j.2040-4603.2014.tb00545.x","article-title":"Sensory nerves in lung and airways","volume":"4","author":"Lee","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jaci.2016.08.009_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000026376","article-title":"Autonomic innervation of human airways: structure, function, and pathophysiology in asthma","volume":"6","author":"van der Velden","year":"1999","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jaci.2016.08.009_bib33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/labinvest.3700412","article-title":"Functional facets of the pulmonary neuroendocrine system","volume":"86","author":"Linnoila","year":"2006","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaci.2016.08.009_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1465-9921-6-115","article-title":"A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium","volume":"6","author":"Weichselbaum","year":"2005","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2016.08.009_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.coph.2004.01.010","article-title":"Purinergic signalling in the lung: important in asthma and COPD?","volume":"4","author":"Adriaensen","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jaci.2016.08.009_bib36","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1513\/AnnalsATS.201502-082OC","article-title":"Airway inflammation after bronchial thermoplasty for severe asthma","volume":"12","author":"Darcy","year":"2015","journal-title":"Ann Am Thorac Soc"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630896X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491630896X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:03:24Z","timestamp":1758791004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491630896X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S009167491630896X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.009","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}