{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:38:10Z","timestamp":1791916690165,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003842","name":"Ilhan Food Allergy Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003842","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Children's Hospital at Westmead"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jaci.2016.08.035","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T07:30:51Z","timestamp":1476516651000},"page":"1621-1628.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":179,"title":["A randomized trial of egg introduction from 4\u00a0months of age in infants at risk for egg allergy"],"prefix":"10.1016","volume":"139","author":[{"given":"John","family":"Wei-Liang Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Van Asperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson M.","family":"Kakakios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne E.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.08.035_bib1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2011.01.039","article-title":"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants","volume":"127","author":"Osborne","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/all.12801","article-title":"Incidence and natural history of hen's egg allergy in the first 2 years of life\u2014the EuroPrevall birth cohort study","volume":"71","author":"Xepapadaki","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.035_bib3","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jaci.2010.12.1106","article-title":"Allergy-related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006","volume":"127","author":"Salo","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jaci.2007.09.040","article-title":"The natural history of egg allergy","volume":"120","author":"Savage","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.anai.2014.12.022","article-title":"Treatment of allergic reactions and quality of life among caregivers of food-allergic children","volume":"114","author":"Ward","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1542\/peds.86.4.541","article-title":"Early solid feeding and recurrent\u00a0childhood eczema: a 10-year longitudinal study","volume":"86","author":"Fergusson","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2016.08.035_bib7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/all.12334","article-title":"Primary prevention of food allergy in children and adults: systematic review","volume":"69","author":"de Silva","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.035_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jaci.2010.07.028","article-title":"Can early introduction of egg prevent egg allergy in infants? A\u00a0population-based study","volume":"126","author":"Koplin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.2009-0813","article-title":"Age at the introduction of solid foods during the first year and allergic sensitization at age 5 years","volume":"125","author":"Nwaru","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2016.08.035_bib10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jaci.2008.08.039","article-title":"Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy","volume":"122","author":"Du Toit","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaci.2016.08.035_bib12","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1056\/NEJMoa1514210","article-title":"Randomized trial of introduction of allergenic foods in breast-fed infants","volume":"374","author":"Perkin","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.08.035_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2016.08.035_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000247298","article-title":"Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis","volume":"186","year":"1993","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2016.08.035_bib15","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaci.2012.10.017","article-title":"Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report","volume":"130","author":"Sampson","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jaci.2013.05.002","article-title":"Early regular egg exposure in infants with eczema: a randomized controlled trial","volume":"132","author":"Palmer","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib17","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1046\/j.1365-2222.2000.00928.x","article-title":"Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children","volume":"30","author":"Sporik","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.035_bib18","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.jaci.2006.03.029","article-title":"Diagnostic accuracy of skin prick testing in children with tree nut allergy","volume":"117","author":"Ho","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jaci.2012.10.034","article-title":"Threshold dose distributions for 5 major allergenic foods in children","volume":"131","author":"Blom","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.035_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cea.12406","article-title":"Which infants with eczema are at risk of food allergy? Results from a population-based cohort","volume":"45","author":"Martin","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.035_bib21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/cea.12699","article-title":"Nut allergy prevalence and differences between Asian born children and Australian born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia","volume":"46","author":"Panjari","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.035_bib22","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/all.12487","article-title":"Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents","volume":"69","author":"Koplin","year":"2014","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:06:25Z","timestamp":1758791185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916311186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0091674916311186"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.035","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized trial of egg introduction from 4\u00a0months of age in infants at risk for egg allergy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}