{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:25Z","timestamp":1791274465720,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KE 1462\/2-1"],"award-info":[{"award-number":["KE 1462\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EE9405\/5"],"award-info":[{"award-number":["01EE9405\/5"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EE9406"],"award-info":[{"award-number":["01EE9406"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["07 ALE 27"],"award-info":[{"award-number":["07 ALE 27"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["07015633"],"award-info":[{"award-number":["07015633"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"Deutsches Zentrum f\u00fcr Lungenforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["250268"],"award-info":[{"award-number":["250268"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FOOD-CT-2006-31708"],"award-info":[{"award-number":["FOOD-CT-2006-31708"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["KBBE-2007-2-2-06"],"award-info":[{"award-number":["KBBE-2007-2-2-06"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["QLK4-CT-2001-00250"],"award-info":[{"award-number":["QLK4-CT-2001-00250"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jaci.2016.08.046","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:18:38Z","timestamp":1476922718000},"page":"1935-1945.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts"],"prefix":"10.1016","volume":"139","author":[{"given":"Alexander J.","family":"Hose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Depner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Illi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Wahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra Ina","family":"Pfefferle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Schmau\u00dfer-Hechfellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-1528","authenticated-orcid":false,"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Lauener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Karvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Roduit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Dalphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Riedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Pekkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Ege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Peter","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Zepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Wahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate L.","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl E.","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Grabenhenrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg J.","family":"Loss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjut","family":"Roponen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Tiittanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Remes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Braun-Fahrl\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Frei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Kaulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Dalphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Doekes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bl\u00fcmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.08.046_bib1","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/thx.2007.093187","article-title":"Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood","volume":"63","author":"Henderson","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2016.08.046_bib2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jaci.2011.02.002","article-title":"Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA","volume":"127","author":"Savenije","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1164\/rccm.201307-1198OC","article-title":"Clinical and epidemiologic phenotypes of childhood asthma","volume":"189","author":"Depner","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jaci.2012.11.048","article-title":"Atopic sensitization in the first year of life","volume":"131","author":"Depner","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1164\/ajrccm.165.2.2104032","article-title":"A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status","volume":"165","author":"Rhodes","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(06)69286-6","article-title":"Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study","volume":"368","author":"Illi","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.08.046_bib7","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1365-2222.2009.03348.x","article-title":"Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort","volume":"39","author":"Matricardi","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2222.1999.00631.x","article-title":"On early sensitization to allergens and development of respiratory symptoms","volume":"29","author":"Sherrill","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0091-6749(90)90223-Q","article-title":"Longitudinal changes in atopy during a 4-year period: relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren","volume":"85","author":"Peat","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib10","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1398-9995.2009.02055.x","article-title":"Longitudinal trends of total and allergen-specific IgE throughout childhood","volume":"64","author":"Matricardi","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1067\/mai.2001.118786","article-title":"The pattern of atopic sensitization is associated with the development of asthma in childhood","volume":"108","author":"Illi","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1046\/j.1365-2222.1998.00439.x","article-title":"Prediction of sensitization to inhalant allergens in childhood: evaluating family history, atopic dermatitis and sensitization to food allergens. The MAS Study Group. Multicentre Allergy Study","volume":"28","author":"Kulig","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2045-7022-4-16","article-title":"Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease","volume":"4","author":"Migueres","year":"2014","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib14","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1398-9995.2009.02089.x","article-title":"GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe","volume":"64","author":"Burbach","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib15","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1016\/j.ejim.2011.05.009","article-title":"Monosensitization and polysensitization in allergic rhinitis","volume":"22","author":"Ciprandi","year":"2011","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/all.12670","article-title":"Sensitization pattern affects the asthma-risk in Finnish adult population","volume":"70","author":"Toppila-Salmi","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1399-3038.2010.00993.x","article-title":"Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polysensitized children","volume":"22","author":"de Jong","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00011-015-0826-9","article-title":"Allergic rhinitis phenotypes based on mono-allergy or poly-allergy","volume":"64","author":"Gelardi","year":"2015","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jaci.2016.08.046_bib19","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200907-1101OC","article-title":"Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study","volume":"181","author":"Simpson","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib20","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jaci.2014.01.022","article-title":"Atopic phenotypes identified with latent class analyses at age 2 years","volume":"134","author":"Havstad","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/all.12134","article-title":"Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts","volume":"68","author":"Lazic","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/cea.12095","article-title":"Atopy phenotypes in the Childhood Asthma Prevention Study (CAPS) cohort and the relationship with allergic disease: clinical mechanisms in allergic disease","volume":"43","author":"Garden","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJM198902023200502","article-title":"Association of asthma with serum IgE levels and skin-test reactivity to allergens","volume":"320","author":"Burrows","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1399-3038.1994.tb00343.x","article-title":"Atopic diseases in infancy. The German multicenter atopy study (MAS-90)","volume":"5","author":"Bergmann","year":"1994","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1398-9995.2006.01009.x","article-title":"The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe","volume":"61","author":"von Mutius","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.08.046_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1164\/rccm.200708-1248OC","article-title":"Reference ranges for spirometry across all ages: a new approach","volume":"177","author":"Stanojevic","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/10705510701575602","article-title":"PROC LCA: a SAS procedure for latent class analysis","volume":"14","author":"Lanza","year":"2007","journal-title":"Struct Equ Modeling"},{"key":"10.1016\/j.jaci.2016.08.046_bib28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/pai.12287","article-title":"Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA Study","volume":"25","author":"Just","year":"2014","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib29","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jaci.2007.02.016","article-title":"Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort","volume":"119","author":"Rowe","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa1009705","article-title":"Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children","volume":"364","author":"Busse","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2016.08.046_bib31","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jaci.2015.09.008","article-title":"Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations","volume":"136","author":"Teach","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.08.046_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nri2273","article-title":"IgE in allergy and asthma today","volume":"8","author":"Gould","year":"2008","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:05:40Z","timestamp":1758791140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916311356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0091674916311356"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.046","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.08.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}