{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:40:32Z","timestamp":1790710832683,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jaci.2016.09.018","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T08:46:17Z","timestamp":1476521177000},"page":"1873-1884.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation"],"prefix":"10.1016","volume":"139","author":[{"given":"Jennifer","family":"Jurkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Krump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"K\u00f6ffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Fieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Borek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Eisenwort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Mages","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mechtcheriakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Meshcheryakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Elbe-B\u00fcrger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Strobl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.09.018_bib1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.it.2010.08.006","article-title":"In\u00a0vivo function of Langerhans cells and dermal DC","volume":"31","author":"Kaplan","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells","volume":"8","author":"Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib3","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/jid.2011.164","article-title":"Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-\u03b21-dependent human epidermal Langerhans cells","volume":"131","author":"Eisenwort","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.09.018_bib4","doi-asserted-by":"crossref","first-page":"E889","DOI":"10.1073\/pnas.1117674109","article-title":"Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in\u00a0vivo","volume":"109","author":"Gaiser","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2016.09.018_bib5","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/sj.jid.5700882","article-title":"Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1","volume":"127","author":"Zimmerli","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.09.018_bib6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.immuni.2012.03.018","article-title":"Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells","volume":"36","author":"Seneschal","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2014.08.006","article-title":"Human dermal CD14+ cells are a transient population of monocyte-derived macrophages","volume":"41","author":"McGovern","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1182\/blood.V90.4.1425","article-title":"flt3\u00a0ligand in cooperation with transforming growth factor-beta1 potentiates in\u00a0vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions","volume":"90","author":"Strobl","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ni1307","article-title":"Langerhans cells arise from monocytes in\u00a0vivo","volume":"7","author":"Ginhoux","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib10","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.immuni.2012.07.019","article-title":"Two distinct types of Langerhans cells populate the skin during steady state and inflammation","volume":"37","author":"Ser\u00e9","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1084\/jem.187.6.961","article-title":"Transforming\u00a0growth factor beta1, in the presence of granulocyte\/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells","volume":"187","author":"Geissmann","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.09.018_bib12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1189\/jlb.1204746","article-title":"A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes","volume":"78","author":"Hoshino","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2016.09.018_bib13","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.4049\/jimmunol.157.9.3850","article-title":"Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes","volume":"157","author":"Pickl","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1600-065X.2007.00551.x","article-title":"Dendritic cell subsets in health and disease","volume":"219","author":"Ueno","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2016.09.018_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.humimm.2009.02.004","article-title":"Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines","volume":"70","author":"Klechevsky","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib16","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1182\/blood-2009-03-210484","article-title":"Reciprocal\u00a0role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation","volume":"114","author":"G\u00f6bel","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib17","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/jid.2012.481","article-title":"\u03b2-Catenin promotes the differentiation of epidermal Langerhans dendritic cells","volume":"133","author":"Yasmin","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.09.018_bib18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/sj.emboj.7600085","article-title":"Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation","volume":"23","author":"Fainaru","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2016.09.018_bib19","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1182\/blood-2005-04-1721","article-title":"Differential involvement of PU.1 and Id2 downstream of TGF-\u03b21 during Langerhans-cell commitment","volume":"107","author":"Heinz","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib20","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1084\/jem.20130930","article-title":"Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks","volume":"210","author":"Chopin","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.09.018_bib21","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.4049\/jimmunol.173.4.2780","volume":"173","author":"Ratzinger","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib22","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood.V90.4.1458","article-title":"CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis","volume":"90","author":"Caux","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib23","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.164.7.3600","article-title":"Large-scale culture and selective maturation of human Langerhans cells from\u00a0granulocyte colony-stimulating factor-mobilized CD34+ progenitors","volume":"164","author":"Gatti","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib24","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1242\/jcs.113.23.4313","article-title":"Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling","volume":"113","author":"Varnum-Finney","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jaci.2016.09.018_bib25","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood-2004-02-0412","article-title":"RelB regulates human dendritic cell subset development by promoting monocyte intermediates","volume":"104","author":"Platzer","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood-2006-05-022954","article-title":"Human Langerhans-cell activation triggered in\u00a0vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB","volume":"109","author":"J\u00f6rgl","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib27","first-page":"363","article-title":"Selective expression of CD45 isoforms on functional subpopulations of CD34\u00a0+ hemopoietic cells from human bone marrow","volume":"172","author":"Lansdorp","year":"1990","journal-title":"Cytometry"},{"key":"10.1016\/j.jaci.2016.09.018_bib28","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood.V96.12.3748","article-title":"Characterization of dendritic cell differentiation pathways from cord blood CD34(+)CD7(+)CD45RA(+) hematopoietic progenitor cells","volume":"96","author":"Canque","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib29","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1073\/pnas.172384399","article-title":"Prospective isolation of human clonogenic common myeloid progenitors","volume":"99","author":"Manz","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2016.09.018_bib30","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1182\/blood-2004-05-1845","article-title":"Molecular characterization of early human T\/NK and B-lymphoid progenitor cells in umbilical cord blood","volume":"104","author":"Haddad","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib31","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/sj.emboj.7601824","article-title":"The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation","volume":"26","author":"Feinberg","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2016.09.018_bib32","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.4049\/jimmunol.180.8.5645","article-title":"Kruppel-like factor 4 is essential for in ammatory monocyte differentiation in\u00a0vivo","volume":"180","author":"Alder","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib33","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biocel.2007.07.018","article-title":"Kruppel-like transcription factors: a functional family","volume":"40","author":"Pearson","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jaci.2016.09.018_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00441-011-1186-6","article-title":"Klf10 and Klf11 as mediators of TGF-beta superfamily signaling","volume":"347","author":"Spittau","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jaci.2016.09.018_bib35","doi-asserted-by":"crossref","first-page":"38247","DOI":"10.1074\/jbc.M509378200","article-title":"Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages","volume":"280","author":"Feinberg","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2016.09.018_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.20081747","article-title":"HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells","volume":"206","author":"Schuster","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.09.018_bib37","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1038\/onc.2012.517","article-title":"Non-canonical Notch signaling activates IL-6\/JAK\/STAT signaling in breast tumor cells and is controlled by p53 and IKK\u03b1\/IKK\u03b2","volume":"32","author":"Jin","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jaci.2016.09.018_bib38","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1038\/ncomms5806","article-title":"Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation","volume":"5","author":"Hirata","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2016.09.018_bib39","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1182\/blood-2012-02-410241","article-title":"Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells","volume":"120","author":"Hutter","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2016.09.018_bib41","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.4049\/jimmunol.165.3.1381","article-title":"Functional involvement of E-cadherin in TGF-beta 1-induced cell cluster formation of in\u00a0vitro developing human Langerhans-type dendritic cells","volume":"165","author":"Riedl","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib42","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1182\/blood.V96.13.4276","article-title":"Ligation of E-cadherin on in\u00a0vitro-generated immature Langerhans-type dendritic cells inhibits their maturation","volume":"96","author":"Riedl","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/intimm\/dxn024","article-title":"KLF4 is a FOXO target gene that suppresses B cell proliferation","volume":"20","author":"Yusuf","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.immuni.2008.07.013","article-title":"Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells","volume":"29","author":"Klechevsky","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.0022-202x.2001.01665.x","article-title":"Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases","volume":"118","author":"Wollenberg","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2016.09.018_bib46","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.4049\/jimmunol.163.9.4869","article-title":"CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner","volume":"163","author":"Jaksits","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.immuni.2014.04.016","article-title":"Development and function of dendritic cell subsets","volume":"40","author":"Mildner","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib48","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.immuni.2015.04.017","article-title":"Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses","volume":"42","author":"Tussiwand","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.09.018_bib49","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/ni731","article-title":"Dermal-resident CD14+ cells differentiate into Langerhans cells","volume":"2","author":"Larregina","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib50","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1091\/mbc.E14-12-1591","article-title":"Notch and TGF-\u03b2 pathways cooperatively regulate receptor protein tyrosine phosphatase-\u03ba (PTPRK) gene expression in human primary keratinocytes","volume":"26","author":"Xu","year":"2015","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaci.2016.09.018_bib51","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood-2014-08-593582","article-title":"CD1c+ blood dendritic cells have Langerhans cell potential","volume":"125","author":"Milne","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib52","doi-asserted-by":"crossref","first-page":"G490","DOI":"10.1152\/ajpgi.90393.2008","article-title":"KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract","volume":"296","author":"Zheng","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jaci.2016.09.018_bib53","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.1074\/jbc.M110.179952","article-title":"Regulation of Kruppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling","volume":"286","author":"Hu","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2016.09.018_bib54","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1371\/journal.pmed.0040253","article-title":"Expansion of regulatory T cells in patients with Langerhans cell histiocytosis","volume":"4","author":"Senechal","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.jaci.2016.09.018_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.1002485","article-title":"Glucocorticosteroids modify Langerhans cells to produce TGF-\u03b2 and expand regulatory T cells","volume":"186","author":"Stary","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bib56","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1182\/blood.V98.5.1402","article-title":"The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells","volume":"98","author":"Ohishi","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bib57","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ni903","article-title":"Transcriptional profiling identifies Id2 function in dendritic cell development","volume":"4","author":"Hacker","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.09.018_bibE1","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1242\/jcs.113.23.4313","article-title":"Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling","volume":"113","author":"Varnum-Finney","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jaci.2016.09.018_bibE2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1182\/blood.V90.4.1425","article-title":"flt3 ligand in cooperation with transforming growth factor-beta1 potentiates in\u00a0vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions","volume":"90","author":"Strobl","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bibE3","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2353\/ajpath.2010.100277","article-title":"Host defense mechanisms in secondary syphilitic lesions","volume":"177","author":"Stary","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2016.09.018_bibE4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2164-5-2","article-title":"A comparative analysis of data generated using two different target preparation methods for hybridization to high-density oligonucleotide microarrays","volume":"5","author":"Gold","year":"2004","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jaci.2016.09.018_bibE5","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1182\/blood-2012-02-410241","article-title":"Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells","volume":"120","author":"Hutter","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bibE6","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2016.09.018_bibE7","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2016.09.018_bibE8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood-2006-05-022954","article-title":"Human\u00a0Langerhans-cell activation triggered in\u00a0vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB","volume":"109","author":"J\u00f6rgl","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bibE9","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood-2004-02-0412","article-title":"RelB regulates human dendritic cell subset development by promoting monocyte intermediates","volume":"104","author":"Platzer","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2016.09.018_bibE10","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/sj.emboj.7601824","article-title":"The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation","volume":"26","author":"Feinberg","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2016.09.018_bibE11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.20081747","article-title":"HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells","volume":"206","author":"Schuster","year":"2009","journal-title":"J Exp Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674916311216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:07:58Z","timestamp":1758791278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674916311216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0091674916311216"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.09.018","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}