{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:01:22Z","timestamp":1779260482772,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jaci.2016.10.052","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T08:01:35Z","timestamp":1484294495000},"page":"836-844.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Patterns of immune development in urban preschoolers with recurrent wheeze and\/or atopy"],"prefix":"10.1016","volume":"140","author":[{"given":"James E.","family":"Gern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Calatroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy F.","family":"Jaffee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Dresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Cruikshank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard M.","family":"Lederman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh A.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-137X","authenticated-orcid":false,"given":"Wayne","family":"Shreffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Gergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meyer","family":"Kattan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan T.","family":"Sandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon R.","family":"Bloomberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.10.052_bib1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0140-6736(08)61451-8","article-title":"Early identification of atopy in the prediction of persistent asthma in children","volume":"372","author":"Sly","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.10.052_bib2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.jaci.2014.01.018","article-title":"Birth cohorts in asthma and allergic diseases: report of a NIAID\/NHLBI\/MeDALL joint workshop","volume":"133","author":"Bousquet","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaci.2015.05.011","article-title":"The mechanism or mechanisms driving atopic asthma initiation: the infant respiratory microbiome moves to center stage","volume":"136","author":"Holt","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jaci.2013.12.1071","article-title":"Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006","volume":"134","author":"Salo","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl\u00a03","key":"10.1016\/j.jaci.2016.10.052_bib5","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1542\/peds.2008-2233C","article-title":"Status of childhood asthma in the United States, 1980-2007","volume":"123","author":"Akinbami","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2016.10.052_bib6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jaci.2010.01.037","article-title":"The Urban Environment and Childhood Asthma study","volume":"125","author":"Gern","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2466-9-17","article-title":"The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population","volume":"9","author":"Gern","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2016.10.052_bib8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/ajim.20264","article-title":"Recombinant factor C assay for measuring endotoxin in house dust: comparison with LAL, and (1--> 3)-beta-D-glucans","volume":"49","author":"Alwis","year":"2006","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.jaci.2016.10.052_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2172-7-29","article-title":"Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study","volume":"7","author":"Shreffler","year":"2006","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib10","series-title":"Statistical analysis with missing data","author":"Little","year":"2002"},{"key":"10.1016\/j.jaci.2016.10.052_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jaci.2014.04.018","article-title":"Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children","volume":"134","author":"Lynch","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jaci.2009.08.021","article-title":"Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses","volume":"124","author":"Gold","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib13","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1365-2222.2008.03018.x","article-title":"Effects of dog ownership in early childhood on immune development and atopic diseases","volume":"38","author":"Bufford","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.10.052_bib14","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1365-2222.2010.03566.x","article-title":"Exposure to dogs is associated with a decreased tumour necrosis factor-\u03b1-producing capacity in early life","volume":"40","author":"Lappalainen","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.10.052_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jaci.2010.05.042","article-title":"Man's best friend? The effect of pet ownership on house dust microbial communities","volume":"126","author":"Fujimura","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/sj.gene.6364162","article-title":"Heritability estimates of innate immunity: an extended twin study","volume":"6","author":"de Craen","year":"2005","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2016.10.052_bib17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jaci.2003.10.044","article-title":"Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy","volume":"113","author":"Hoffjan","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","article-title":"Variation in the human immune system is largely driven by non-heritable influences","volume":"160","author":"Brodin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2016.10.052_bib19","doi-asserted-by":"crossref","first-page":"c4978","DOI":"10.1136\/bmj.c4978","article-title":"Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study","volume":"341","author":"Bisgaard","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2016.10.052_bib20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development","volume":"17","author":"Teo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaci.2016.10.052_bib21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jaci.2013.09.035","article-title":"CD49d-expressing neutrophils differentiate atopic from nonatopic individuals","volume":"133","author":"Sigua","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib22","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.4049\/jimmunol.1002456","article-title":"Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma","volume":"185","author":"Cheung","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1086\/424886","article-title":"The IL12B gene is associated with asthma","volume":"75","author":"Randolph","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaci.2016.10.052_bib24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jaci.2003.10.043","article-title":"Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age","volume":"113","author":"Khoo","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.10.052_bib26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2005.10.002","article-title":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","volume":"117","author":"Gern","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib27","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jaci.2012.02.033","article-title":"Antiviral IFN-gamma responses of monocytes at birth predict respiratory tract illness in the first year of life","volume":"129","author":"Sumino","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib28","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.4049\/jimmunol.0900695","article-title":"Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children","volume":"183","author":"Subrata","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.10.052_bib29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm1770","article-title":"Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease","volume":"14","author":"Kim","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2016.10.052_bibE1","first-page":"1","article-title":"Multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jaci.2016.10.052_bibE2","series-title":"Statistical analysis with missing data","author":"Little","year":"2002"},{"key":"10.1016\/j.jaci.2016.10.052_bibE3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917300301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917300301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:06:58Z","timestamp":1758791218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917300301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0091674917300301"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.10.052","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patterns of immune development in urban preschoolers with recurrent wheeze and\/or atopy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.10.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}