{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:14Z","timestamp":1791405194746,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Science Center in Poland","award":["2011\/01\/B\/NZ6\/00300"],"award-info":[{"award-number":["2011\/01\/B\/NZ6\/00300"]}]},{"name":"National Science Center in Poland","award":["K\/ZDS\/004650"],"award-info":[{"award-number":["K\/ZDS\/004650"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK088181"],"award-info":[{"award-number":["DK088181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK092882"],"award-info":[{"award-number":["DK092882"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jaci.2016.11.052","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T21:29:24Z","timestamp":1485293364000},"page":"121-133.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Broad spectrum antibiotic enrofloxacin modulates contact sensitivity through gut microbiota in a murine model"],"prefix":"10.1016","volume":"140","author":[{"given":"Anna","family":"Strz\u0119pa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Majewska-Szczepanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M.","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Szczepanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.11.052_bib1","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"Dethlefsen","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jaci.2016.11.052_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.it.2012.05.003","article-title":"Antibiotics, microbiota, and immune defense","volume":"33","author":"Ubeda","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib3","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1172\/JCI43918","article-title":"Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans","volume":"120","author":"Ubeda","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2016.11.052_bib4","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1128\/IAI.01520-08","article-title":"Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation","volume":"77","author":"Antonopoulos","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2016.11.052_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/IAI.05496-11","article-title":"Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis","volume":"80","author":"Buffie","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2016.11.052_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ni.2847","article-title":"Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease","volume":"15","author":"Zeissig","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib7","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1542\/peds.2008-1146","article-title":"Antibiotic use in children is associated with increased risk of asthma","volume":"123","author":"Marra","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2016.11.052_bib8","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1378\/chest.06-3008","article-title":"Increased risk of childhood asthma from antibiotic use in early life","volume":"131","author":"Kozyrskyj","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2016.11.052_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/EDE.0b013e31827f520f","article-title":"Mother's and offspring's use of antibiotics and infant allergy to cow's milk","volume":"24","author":"Mets\u00e4l\u00e4","year":"2013","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaci.2016.11.052_bib10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2016.11.052_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev-immunol-030409-101330","article-title":"Interstinal bacteria and the regulation of immune cell homeostasis","volume":"28","author":"Hill","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib12","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1398-9995.2007.01462.x","article-title":"The role of the intestinal microbiota in the development of atopic disorders","volume":"62","author":"Penders","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.11.052_bib13","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.4049\/jimmunol.0900747","article-title":"Role of gut commensal microflora in development of experimental autoimmune encephalomyelitis","volume":"183","author":"Ochoa-Rep\u00e1raz","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrrheum.2010.163","article-title":"Therapy: gut-mediated autoimmune arthritis treated with antibiotics","volume":"6","author":"Ebringer","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jaci.2016.11.052_bib15","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"issue":"suppl\u00a02","key":"10.1016\/j.jaci.2016.11.052_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-3083.2007.02381.x","article-title":"Contact dermatitis: epidemiology and frequent sensitizers to cosmetic","volume":"21","author":"Diepgen","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaci.2016.11.052_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.0022-0477.2001.01250.x","article-title":"Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology: a population-based study using computerized general practice data","volume":"32","author":"Simpson","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.11.052_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000363446","article-title":"Epicutaneous immunization with TNP-Ig and Zymosan induces TCR\u03b1\u03b2+ CD4+ contrasuppressor cells that reverse skin-induced suppression via IL-17A","volume":"164","author":"Majewska-Szczepanik","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1365-2672.2004.02409.x","article-title":"Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR","volume":"97","author":"Rinttila","year":"2004","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.jaci.2016.11.052_bib20","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.1128\/AEM.68.11.5445-5451.2002","article-title":"Development of 16S rRNA-gene-targeted group-specific primers for the detection and identification of predominant bacteria in human feces","volume":"68","author":"Matsuki","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jaci.2016.11.052_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1099\/00221287-148-1-257","article-title":"Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set","volume":"148","author":"Nadkarni","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.jaci.2016.11.052_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaci.2016.11.052_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.jaci.2016.11.052_bib24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2016.11.052_bib25","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jaci.2016.11.052_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/imr.12180","article-title":"Microbiota activation and regulation of innate and adaptive immunity","volume":"260","author":"Alexander","year":"2014","journal-title":"Immunol Rev"},{"issue":"suppl\u00a01","key":"10.1016\/j.jaci.2016.11.052_bib27","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2016.11.052_bib28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.11.052_bib29","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/ncomms9424","article-title":"Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis","volume":"6","author":"Zanvit","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2016.11.052_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pharep.2015.07.002","article-title":"Oral treatment with enrofloxacin early in life promotes Th2-mediated immune response in mice","volume":"68","author":"Strz\u0119pa","year":"2016","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jaci.2016.11.052_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2180-12-95","article-title":"Unbalance of intestinal microbiota in atopic children","volume":"12","author":"Candela","year":"2012","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jaci.2016.11.052_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2011.10.025","article-title":"Low diversity of the gut microbiota in infants with atopic eczema","volume":"129","author":"Abrahamsson","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jaci.2015.08.021","article-title":"Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis","volume":"137","author":"Song","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3177\/jnsv.56.260","article-title":"2,4-Dinitrofluorobenzene-induced contact hypersensitivity response in NC\/Nga mice fed fructo-oligosaccharide","volume":"56","author":"Fujiwara","year":"2010","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.jaci.2016.11.052_bib35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1017\/S000711450999198X","article-title":"Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC\/Nga mice","volume":"103","author":"Fujiwara","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jaci.2016.11.052_bib36","doi-asserted-by":"crossref","first-page":"e4903","DOI":"10.1371\/journal.pone.0004903","article-title":"Oral probiotic control skin inflammation by acting on both effector and regulatory T cells","volume":"4","author":"Hacini-Rachinel","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.11.052_bib37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1017\/S0007114507901221","article-title":"Consumption of fructo-oligosaccharide reduces 2,4-dinnitrofluorobenzene-induced contact hypersensitivity in mice","volume":"100","author":"Watanabe","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jaci.2016.11.052_bib38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.smim.2011.07.005","article-title":"Type 1 regulatory T cells (Tr1) in autoimmunity","volume":"23","author":"Pot","year":"2011","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4161\/gmic.1.2.11515","article-title":"Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora","volume":"1","author":"Ochoa-Rep\u00e1raz","year":"2010","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jaci.2016.11.052_bib40","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2353\/ajpath.2007.061279","article-title":"CD19 expression in B cells is important for suppression of contact sensitivity","volume":"171","author":"Watanabe","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2016.11.052_bib41","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1084\/jem.184.6.2129","article-title":"Gamma delta T cells from tolerized alpha beta T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in\u00a0vivo, and their interferon-gamma production in\u00a0vitro","volume":"184","author":"Szczepanik","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2016.11.052_bib42","doi-asserted-by":"crossref","first-page":"e9836","DOI":"10.1371\/journal.pone.0009836","article-title":"Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome","volume":"5","author":"Jakobsson","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2016.11.052_bib43","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fmicb.2011.00180","article-title":"Gut microbiota, immunity, and disease: complex relationship","volume":"2","author":"Kosiewicz","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jaci.2016.11.052_bib44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/mi.2010.29","article-title":"A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease","volume":"3","author":"Ochoa-Rep\u00e1raz","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2016.11.052_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.200806-951OC","article-title":"Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice","volume":"179","author":"Karimi","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2016.11.052_bib46","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1440-1746.2009.06193.x","article-title":"Oral Bifidobacterium modulates intestinal immune inflammation in mice with food allergy","volume":"25","author":"Zhang","year":"2010","journal-title":"J Gastroeterol Hepatol"},{"key":"10.1016\/j.jaci.2016.11.052_bib47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","article-title":"The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses","volume":"31","author":"Gaboriau-Routhiau","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2016.11.052_bibE1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000363446","article-title":"Epicutaneous immunization with TNP-Ig and Zymosan induces TCR \u03b1\u03b2+CD4+ contrasuppressor cells that reverse skin-induced suppression via IL-17A","volume":"164","author":"Majewska-Szczepanik","year":"2014","journal-title":"Int Arch Allergy Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917300568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917300568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:04:36Z","timestamp":1758791076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917300568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0091674917300568"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.11.052","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broad spectrum antibiotic enrofloxacin modulates contact sensitivity through gut microbiota in a murine model","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.11.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}