{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:15:14Z","timestamp":1768878914122,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jaci.2016.12.990","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T23:18:08Z","timestamp":1490397488000},"page":"1616-1621.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A\u00a0randomized clinical trial"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-1260","authenticated-orcid":false,"given":"Lisbeth Marianne","family":"Th\u00f8stesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone Graff","family":"Stensballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte Thybo","family":"Pihl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Marie","family":"Birk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N\u00f8rrelykke","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aksel Karl Georg","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Aaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette Wind","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe Lisbeth","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine Stabell","family":"Benn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul-Erik","family":"Kofoed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2016.12.990_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ppul.20644","article-title":"Prevalence of asthma-like symptoms in young children","volume":"42","author":"Bisgaard","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2016.12.990_bib2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach","volume":"32","author":"Brand","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2016.12.990_bib3","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ppul.20227","article-title":"Skin-prick testing as a diagnostic aid for childhood asthma","volume":"39","author":"Chan","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaci.2016.12.990_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaci.2005.09.042","article-title":"Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology","volume":"117","author":"Linneberg","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.12.990_bib5","doi-asserted-by":"crossref","first-page":"g4643","DOI":"10.1136\/bmj.g4643","article-title":"Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis","volume":"349","author":"Roy","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2016.12.990_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaci.2010.07.039","article-title":"BCG vaccination and allergy: a systematic review and meta-analysis","volume":"127","author":"Arnoldussen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.12.990_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jaci.2013.08.007","article-title":"Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis","volume":"133","author":"Linehan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.12.990_bib8","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2016.12.990_bib9","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.4049\/jimmunol.163.4.2249","article-title":"Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination","volume":"163","author":"Marchant","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2016.12.990_bib10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0140-6736(98)05104-6","article-title":"Development of allergen-specific T-cell memory in atopic and normal children","volume":"353","author":"Prescott","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2016.12.990_bib11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jaci.2006.12.672","article-title":"Is the prevalence of wheeze in children altered by neonatal BCG vaccination?","volume":"119","author":"Linehan","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2016.12.990_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/infdis\/jir240","article-title":"Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period?","volume":"204","author":"Aaby","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2016.12.990_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/INF.0b013e3182458289","article-title":"Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guerin vaccination at first health center contact","volume":"31","author":"Biering-Sorensen","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2016.12.990_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1586\/14760584.5.2.277","article-title":"Bacillus Calmette-Guerin vaccination and infant mortality","volume":"5","author":"Roth","year":"2006","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.jaci.2016.12.990_bib15","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/adc.2009.157537","article-title":"The non-specific effects of vaccines","volume":"95","author":"Shann","year":"2010","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2016.12.990_bib16","first-page":"695","article-title":"Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971-2010","volume":"46","author":"Rieckmann","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2016.12.990_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cct.2015.04.006","article-title":"Bacillus Calmette-Guerin immunisation at birth and morbidity among Danish children: a prospective, randomised, clinical trial","volume":"42","author":"Thostesen","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.jaci.2016.12.990_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1034\/j.1398-9995.2001.056005377.x","article-title":"Validation of a new questionnaire on asthma, allergic rhinitis, and conjunctivitis in young adults","volume":"56","author":"Kilpelainen","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2016.12.990_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2222.2007.02859.x","article-title":"Bacille-Calmette-Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single-blind study","volume":"38","author":"Steenhuis","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.12.990_bib20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/01.inf.0000227829.64686.ae","article-title":"Sex differential effects of routine immunizations and childhood survival in rural Malawi","volume":"25","author":"Aaby","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaci.2016.12.990_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/cid\/ciu354","article-title":"Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival","volume":"59","author":"Aaby","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2016.12.990_bib22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1365-2222.2000.00803.x","article-title":"Early BCG vaccination and reduction in atopy in Guinea-Bissau","volume":"30","author":"Aaby","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2016.12.990_bib23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/archdischild-2016-310760","article-title":"BCG vaccination at birth and early childhood hospitalisation: a randomised clinical multicentre trial","volume":"102","author":"Stensballe","year":"2017","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2016.12.990_bib24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/pr.2016.142","article-title":"Nonspecific effect of BCG vaccination at birth on early childhood infections: a randomized, clinical multicenter trial","volume":"80","author":"Kjaergaard","year":"2016","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2016.12.990_bib25","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.vaccine.2016.03.100","article-title":"Adverse reactions to the Bacillus Calmette-Guerin (BCG) vaccine in new-born infants-an evaluation of the Danish strain 1331 SSI in a randomized clinical trial","volume":"34","author":"Nissen","year":"2016","journal-title":"Vaccine"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917304736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917304736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:09:55Z","timestamp":1758791395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917304736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0091674917304736"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2016.12.990","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal BCG vaccination has no effect on recurrent wheeze in the first year of life: A\u00a0randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2016.12.990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}