{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:11:59Z","timestamp":1790212319526,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jaci.2017.01.019","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T06:16:33Z","timestamp":1487312193000},"page":"1849-1860.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":134,"title":["Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation"],"prefix":"10.1016","volume":"139","author":[{"given":"Elien","family":"Gevaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Krysko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabri\u00eble","family":"Holtappels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"De Ruyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Nauwynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Uwe","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl\u00a022","key":"10.1016\/j.jaci.2017.01.019_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1399-3038.2012.01318.x","article-title":"Chronic rhinosinusitis: from one disease to different phenotypes","volume":"23","author":"Bachert","year":"2012","journal-title":"Pediatr Allergy Immunol"},{"issue":"20","key":"10.1016\/j.jaci.2017.01.019_bib2","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007","author":"Fokkens","year":"2007","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.jaci.2017.01.019_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2500\/105065800781329573","article-title":"Nasal polyposis: from cytokines to growth","volume":"14","author":"Bachert","year":"2000","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2017.01.019_bib4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jaci.2010.07.007","article-title":"Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma","volume":"126","author":"Bachert","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib6","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","article-title":"Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia","volume":"158","author":"Simon","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2500\/ajra.2014.28.4024","article-title":"The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3-year prospective observational study","volume":"28","author":"Vlaminck","year":"2014","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib8","first-page":"123s","article-title":"The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma","volume":"13","author":"Frigas","year":"1991","journal-title":"Eur Respir J Suppl"},{"key":"10.1016\/j.jaci.2017.01.019_bib9","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaci.2010.12.1103","article-title":"Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways","volume":"127","author":"Dworski","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nm.1855","article-title":"Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense","volume":"14","author":"Yousefi","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2017.01.019_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1398-9995.2012.02868.x","article-title":"Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps","volume":"67","author":"Morshed","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.coi.2012.08.010","article-title":"Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease","volume":"24","author":"Yousefi","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib13","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jaci.2004.07.013","article-title":"Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis","volume":"114","author":"Van Zele","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib14","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1462-5822.2006.00792.x","article-title":"How do microbes evade neutrophil killing?","volume":"8","author":"Urban","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jaci.2017.01.019_bib15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1111\/all.12507","article-title":"Extracellular DNA traps in bronchoalveolar fluid from a murine eosinophilic pulmonary response","volume":"69","author":"Cunha","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jaci.2010.11.002","article-title":"Eosinophil extracellular DNA traps in skin diseases","volume":"127","author":"Simon","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/all.12570","article-title":"Active eosinophilic esophagitis is characterized by epithelial barrier defects and eosinophil extracellular trap formation","volume":"70","author":"Simon","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaci.2015.04.041","article-title":"Eosinophil extracellular trap cell death-derived DNA traps: Their presence in secretions and functional attributes","volume":"137","author":"Ueki","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1398-9995.2009.02313.x","article-title":"Staphylococcus aureus enterotoxin B augments granulocyte migration and survival via airway epithelial cell activation","volume":"65","author":"Huvenne","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib20","doi-asserted-by":"crossref","first-page":"e93754","DOI":"10.1371\/journal.pone.0093754","article-title":"Suppression of cytokine release by fluticasone furoate vs. mometasone furoate in human nasal tissue ex-vivo","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.01.019_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1398-9995.2010.02498.x","article-title":"Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis","volume":"66","author":"Krysko","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.01.019_bib22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2500\/ajr.2007.21.2997","article-title":"Sinonasal epithelial cell expression of toll-like receptor 9 is decreased in chronic rhinosinusitis with polyps","volume":"21","author":"Ramanathan","year":"2007","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2017.01.019_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2500\/ajr.2008.22.3136","article-title":"Th2 cytokines associated\u00a0with chronic rhinosinusitis with polyps down-regulate the antimicrobial\u00a0immune function of human sinonasal epithelial cells","volume":"22","author":"Ramanathan","year":"2008","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2017.01.019_bib24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2012.05.052","article-title":"Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-gamma and IL-4","volume":"130","author":"Soyka","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib25","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.molcel.2015.01.026","article-title":"Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation","volume":"57","author":"Soragni","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2017.01.019_bib26","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/0091-6749(94)90343-3","article-title":"Biochemical properties, activities, and presence in biologic fluids of eosinophil granule major basic protein","volume":"94","author":"Popken-Harris","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib27","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.jaci.2015.09.005","article-title":"Association of periostin expression with eosinophilic inflammation in nasal polyps","volume":"136","author":"Wang","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/mi.2008.15","article-title":"Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses","volume":"1","author":"Blanchard","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.immunol.25.022106.141718","article-title":"TSLP: an epithelial cell cytokine that regulates T cell differentiation\u00a0by conditioning dendritic cell maturation","volume":"25","author":"Liu","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2017.01.019_bib30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J Cell Biol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917302361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917302361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:07:37Z","timestamp":1758791257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917302361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0091674917302361"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.01.019","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}