{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:45:32Z","timestamp":1790196332209,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jaci.2017.05.040","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T04:30:10Z","timestamp":1497933010000},"page":"1288-1298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-1300","authenticated-orcid":false,"given":"Joseph","family":"Ndika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-9246","authenticated-orcid":false,"given":"Liisa","family":"Airaksinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hille","family":"Suojalehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piia","family":"Karisola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Fyhrquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Puustinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-8923","authenticated-orcid":false,"given":"Harri","family":"Alenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.05.040_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2010.06.047","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision","volume":"126","author":"Bro\u017cek","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0167-5699(97)01241-3","article-title":"The genetics and complexity of allergy and asthma","volume":"19","author":"Barnes","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaci.2017.05.040_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2011.01029.x","article-title":"The genetics of asthma and allergic disease: a 21st Century perpsective","volume":"242","author":"Ober","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2017.05.040_bib5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jaci.2011.08.030","article-title":"A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order","volume":"128","author":"Ramasamy","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/rr80","article-title":"Impact of rhinitis on airway inflammation: biological and therapeutic implications","volume":"2","author":"Passalacqua","year":"2001","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2017.05.040_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5415\/apallergy.2011.1.3.157","article-title":"Asia Pacific allergy","volume":"1","author":"Pawankar","year":"2011","journal-title":"Asia Pac Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.alit.2016.04.011","article-title":"Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine","volume":"65","author":"Agache","year":"2016","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2017.05.040_bib9","doi-asserted-by":"crossref","first-page":"e23563","DOI":"10.1371\/journal.pone.0023563","article-title":"Identification of novel biomarkers in seasonal allergic rhinitis by combining proteomic, multivariate and pathway analysis","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.05.040_bib10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1398-9995.2010.02444.x","article-title":"A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis","volume":"66","author":"Wang","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib11","doi-asserted-by":"crossref","first-page":"E91","DOI":"10.1002\/lary.25003","article-title":"Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: a proteomic study","volume":"125","author":"Tomazic","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2017.05.040_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jprot.2015.12.021","article-title":"Seasonal proteome changes of nasal mucus reflect perennial inflammatory response and reduced defence mechanisms and plasticity in allergic rhinitis","volume":"133","author":"Tomazic","year":"2016","journal-title":"J Proteomics"},{"key":"10.1016\/j.jaci.2017.05.040_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/pr050341h","article-title":"Comparative proteomics of nasal fluid in seasonal allergic rhinitis","volume":"5","author":"Ghafouri","year":"2006","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jaci.2017.05.040_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1398-9995.2009.02101.x","article-title":"A network analysis of the single nucleotide polymorphisms in acute allergic diseases","volume":"65","author":"Renkonen","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaci.2008.11.048","article-title":"Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients","volume":"124","author":"Joenv\u00e4\u00e4r\u00e4","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1398-9995.2009.02181.x","article-title":"Time-series nasal epithelial transcriptomics during natural pollen exposure in healthy subjects and allergic patients","volume":"65","author":"Mattila","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2017.05.040_bib18","first-page":"2513","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaci.2017.05.040_bib19","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014050","article-title":"Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins","volume":"11","author":"Geiger","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jaci.2017.05.040_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Meth"},{"key":"10.1016\/j.jaci.2017.05.040_bib21","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl\u00a02","key":"10.1016\/j.jaci.2017.05.040_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/nar\/gkq537","article-title":"The\u00a0GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2017.05.040_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2017.05.040_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2014.06.036","article-title":"Allergens and the airway epithelium response: gateway to allergic sensitization","volume":"134","author":"Lambrecht","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2013.11.025","article-title":"Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease","volume":"133","author":"Poole","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib26","doi-asserted-by":"crossref","first-page":"e108671","DOI":"10.1371\/journal.pone.0108671","article-title":"Proteomic analysis of nasal epithelial cells from cystic fibrosis patients","volume":"9","author":"Jeanson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.05.040_bib27","first-page":"2","article-title":"Proteomics in detection and monitoring chronic lung diseases: the human nasal epithelium as a molecular model","volume":"7","author":"Sim\u00f5es","year":"2012","journal-title":"J Allergy Ther"},{"key":"10.1016\/j.jaci.2017.05.040_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1046\/j.1365-2222.2000.00690.x","article-title":"Nasal lavage mediator profile and cellular composition of nasal brushing material during latex challenge tests","volume":"30","author":"Raulf-Heimsoth","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib29","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/labinvest.3780090","article-title":"Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells","volume":"80","author":"Penque","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaci.2017.05.040_bib30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-arplant-042809-112132","article-title":"Quantitation in mass-spectrometry-based proteomics","volume":"61","author":"Schulze","year":"2010","journal-title":"Annu Rev Plant Biol"},{"key":"10.1016\/j.jaci.2017.05.040_bib31","unstructured":"Hao Z, Zhang Y, Eliuk S, Blethrow J, Horn D, Zabrouskov V, et al. A\u00a0Quadrupole-orbitrap hybrid mass spectrometer offers highest benchtop performance for in-depth analysis of complex proteomes. Thermo Scientific application note; 2012."},{"key":"10.1016\/j.jaci.2017.05.040_bib32","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jaci.2017.05.040_bib33","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/ac0498563","article-title":"A model for random sampling and estimation of\u00a0relative protein abundance in shotgun proteomics","volume":"76","author":"Liu","year":"2004","journal-title":"Anal Chem"},{"key":"10.1016\/j.jaci.2017.05.040_bib34","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1002\/elps.200900210","article-title":"The consequences of sample pooling in proteomics: Aa empirical study","volume":"30","author":"Diz","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jaci.2017.05.040_bib35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.187.4.497","article-title":"Wegener's granulomatosis: anti\u2013proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response","volume":"187","author":"Sibelius","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.05.040_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/ATVBAHA.112.300474","article-title":"Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function","volume":"33","author":"Kuckleburg","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jaci.2017.05.040_bib37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jaci.2013.09.040","article-title":"Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis","volume":"133","author":"Tomazic","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cea.12597","article-title":"Diesel exhaust particles exacerbate allergic rhinitis in mice by disrupting the nasal epithelial barrier","volume":"46","author":"Fukuoka","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.05.040_bib39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jaci.2015.10.050","article-title":"Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression","volume":"137","author":"Steelant","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.05.040_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/10454411920030040101","article-title":"Cystatins\u2014inhibitors of cysteine proteinases","volume":"3","author":"Bobek","year":"1992","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.jaci.2017.05.040_bib41","doi-asserted-by":"crossref","first-page":"e67057","DOI":"10.1371\/journal.pone.0067057","article-title":"Cystatin SN upregulation in patients with seasonal allergic rhinitis","volume":"8","author":"Imoto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.05.040_bib42","unstructured":"Siebold MA, Burchard E, inventors; National Jewish Health, the Regents of the University of California, assignee. Methods of identifying and treating subjects having inflammatory subphenotypes of asthma. United States patent application US 15\/008,094. 2016 Jan 27."},{"key":"10.1016\/j.jaci.2017.05.040_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0079518","article-title":"Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells","volume":"8","author":"Hsu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.05.040_bib44","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1128\/JVI.02744-14","article-title":"Interferon-induced Ifit proteins: their role in viral pathogenesis","volume":"89","author":"Fensterl","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2017.05.040_bib45","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s12864-015-1635-9","article-title":"Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection","volume":"16","author":"Koltes","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jaci.2017.05.040_bib46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tim.2014.12.003","article-title":"Mx GTPases: dynamin-like antiviral machines of innate immunity","volume":"23","author":"Haller","year":"2015","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jaci.2017.05.040_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1586\/ers.09.60","article-title":"Role of infection in the development and exacerbation of asthma","volume":"4","author":"Guilbert","year":"2010","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.jaci.2017.05.040_bib48","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.iac.2010.08.002","article-title":"Virus\/allergen interactions and exacerbations of asthma","volume":"30","author":"Kloepfer","year":"2010","journal-title":"Immunol Allergy Clin North Am"},{"issue":"suppl","key":"10.1016\/j.jaci.2017.05.040_bib49","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1513\/AnnalsATS.201503-153AW","article-title":"Virus\/allergen interaction in asthma exacerbation","volume":"12","author":"Gern","year":"2015","journal-title":"Ann Am Thorac Soc"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491731000X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491731000X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:05:29Z","timestamp":1758791129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491731000X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S009167491731000X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.05.040","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.05.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}