{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:10:43Z","timestamp":1793329843097,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jaci.2017.06.028","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T01:48:07Z","timestamp":1500515287000},"page":"1774-1785.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-202X","authenticated-orcid":false,"given":"Jeremy A.","family":"O'Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano N.","family":"Salicru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-6009","authenticated-orcid":false,"given":"Bruce S.","family":"Bochner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.06.028_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/asheducation-2011.1.257","article-title":"Eosinophilic myeloproliferative disorders","volume":"2011","author":"Klion","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jaci.2017.06.028_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.06.028_bib3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1067\/mai.2000.107127","article-title":"Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils","volume":"105","author":"Kikly","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib4","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s10875-011-9589-4","article-title":"Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil Siglec-8 expression","volume":"31","author":"Hudson","year":"2011","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1006\/bbrc.2000.3866","article-title":"Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene","volume":"278","author":"Foussias","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2017.06.028_bib6","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1182\/blood-2002-10-3058","article-title":"Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis","volume":"101","author":"Nutku","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.06.028_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cyto.2011.10.007","article-title":"IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils","volume":"57","author":"Na","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2017.06.028_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2007.10.004","article-title":"Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement","volume":"121","author":"Yokoi","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/glycob\/cwx026","article-title":"Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties","volume":"27","author":"Yu","year":"2017","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2017.06.028_bib10","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1182\/blood.V86.4.1437.bloodjournal8641437","article-title":"Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in\u00a0vitro","volume":"86","author":"Matsumoto","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.06.028_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0145-2126(88)90050-1","article-title":"Establishment of an immature mast cell line from a patient with mast cell leukemia","volume":"12","author":"Butterfield","year":"1988","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2017.06.028_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jaci.2010.12.1101","article-title":"Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcepsilonRI","volume":"127","author":"Laidlaw","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jim.2012.05.017","article-title":"Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8","volume":"383","author":"Na","year":"2012","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2017.06.028_bib14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.108.2.389","article-title":"Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation","volume":"108","author":"Heuser","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.121.1.61","article-title":"Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification","volume":"121","author":"Hansen","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yexcr.2005.07.003","article-title":"The complement inhibitor, CRIT, undergoes clathrin-dependent endocytosis","volume":"310","author":"Inal","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jaci.2017.06.028_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jcp.1041380311","article-title":"Potassium depletion and hypertonic medium reduce \u201cnon-coated\u201d and clathrin-coated pit formation, as well as endocytosis through these two gates","volume":"138","author":"Carpentier","year":"1989","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jaci.2017.06.028_bib18","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1073\/pnas.79.7.2291","article-title":"Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin","volume":"79","author":"Schlegel","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.06.028_bib19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0014-5793(91)80390-O","article-title":"Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines","volume":"281","author":"Phonphok","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2017.06.028_bib20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.162.1.380","article-title":"Clathrin-coated pit-associated proteins\u00a0are required for alveolar macrophage phagocytosis","volume":"162","author":"Perry","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib21","doi-asserted-by":"crossref","first-page":"C886","DOI":"10.1152\/ajpcell.00416.2008","article-title":"Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils","volume":"297","author":"Eckels","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jaci.2017.06.028_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0076-6879(07)38006-3","article-title":"Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis","volume":"438","author":"Kirchhausen","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jaci.2017.06.028_bib23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.jaci.2017.06.028_bib24","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1073\/pnas.211341698","article-title":"Lipid rafts are required for GLUT4 internalization in adipose cells","volume":"98","author":"Ros-Baro","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.06.028_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-59745-178-9_2","article-title":"Pharmacological inhibition of endocytic pathways: Is it specific enough to be useful?","volume":"440","author":"Ivanov","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib26","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1083\/jcb.135.5.1249","article-title":"A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages","volume":"135","author":"Araki","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/eji.200636195","article-title":"You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling","volume":"36","author":"Barrow","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib28","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1182\/blood.V85.8.2005.bloodjournal8582005","article-title":"Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules","volume":"85","author":"Freeman","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.06.028_bib29","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1074\/jbc.270.13.7533","article-title":"CD22-mediated cell adhesion to cytokine-activated human endothelial cells: positive and negative regulation by\u00a0alpha 2-6-sialylation of cellular glycoproteins","volume":"270","author":"Hanasaki","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.06.028_bib30","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1073\/pnas.95.13.7469","article-title":"Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes","volume":"95","author":"Razi","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.06.028_bib31","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/glycob\/9.11.1225","article-title":"Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation","volume":"9","author":"Razi","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2017.06.028_bib32","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.177.5.2994","article-title":"High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells","volume":"177","author":"Collins","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/jpet.109.152439","article-title":"Eosinophil-selective binding and proapoptotic effect in\u00a0vitro of a synthetic Siglec-8 ligand, polymeric 6\u2032-sulfated sialyl Lewis x","volume":"330","author":"Hudson","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2017.06.028_bib34","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/glycob\/cww024","article-title":"\u201cSiglec\u201dting the allergic response for therapeutic targeting","volume":"26","author":"Bochner","year":"2016","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2017.06.028_bib35","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1093\/glycob\/cwi097","article-title":"Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6\u2032-sulfo-sialyl Lewis X as a preferred glycan ligand","volume":"15","author":"Tateno","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2017.06.028_bib36","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/eji.200324723","article-title":"The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils","volume":"34","author":"Zhang","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"Gerbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2017.06.028_bib38","doi-asserted-by":"crossref","first-page":"e68143","DOI":"10.1371\/journal.pone.0068143","article-title":"Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen","volume":"8","author":"Mao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.06.028_bib39","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1182\/blood-2006-08-039255","article-title":"Defining the in\u00a0vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils","volume":"109","author":"Zhang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.06.028_bib40","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1398-9995.2008.01709.x","article-title":"Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils","volume":"63","author":"Zimmermann","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.06.028_bib41","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1128\/MCB.00383-07","article-title":"Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity","volume":"27","author":"Tateno","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.leukres.2006.05.026","article-title":"Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors","volume":"31","author":"Biedermann","year":"2007","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2017.06.028_bib43","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1182\/blood-2004-07-2784","article-title":"Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity","volume":"105","author":"Walter","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.06.028_bib44","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1189\/jlb.0607388","article-title":"ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2","volume":"83","author":"Walter","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2017.06.028_bib45","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2006.02.025","article-title":"Endocytosis conducts the cell signaling orchestra","volume":"124","author":"Polo","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2017.06.028_bib46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1067\/mai.2002.120550","article-title":"Human eosinophils express two Siglec-8 splice variants","volume":"109","author":"Aizawa","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib47","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.4049\/jimmunol.1003005","article-title":"CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells","volume":"186","author":"O'Reilly","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib48","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nri2056","article-title":"Siglecs and their roles in the immune system","volume":"7","author":"Crocker","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib49","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2014.10.027","article-title":"Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis","volume":"135","author":"Kiwamoto","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib50","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/glycob\/cwr089","article-title":"Glycomic analysis of human mast cells, eosinophils and basophils","volume":"22","author":"North","year":"2012","journal-title":"Glycobiology"},{"key":"10.1016\/j.jaci.2017.06.028_bib51","doi-asserted-by":"crossref","first-page":"E4170","DOI":"10.1073\/pnas.1602214113","article-title":"Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8","volume":"113","author":"Propster","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.06.028_bib52","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jaci.2010.04.005","article-title":"Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma","volume":"125","author":"Busse","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.06.028_bib53","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1056\/NEJMoa1513098","article-title":"Efficacy and safety of midostaurin in advanced systemic mastocytosis","volume":"374","author":"Gotlib","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.06.028_bib54","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.3390\/toxins2112699","article-title":"Ribosome-inactivating proteins: from plant defense to tumor attack","volume":"2","author":"de Virgilio","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jaci.2017.06.028_bib55","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1365-2141.1996.d01-1730.x","article-title":"Saporin, a ribosome-inactivating protein used to prepare immunotoxins, induces cell death via apoptosis","volume":"93","author":"Bergamaschi","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2017.06.028_bib56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<349::AID-IJC13>3.0.CO;2-3","article-title":"Induction of apoptosis by ribosome-inactivating proteins and related immunotoxins","volume":"68","author":"Bolognesi","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaci.2017.06.028_bib57","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/toxins5101698","article-title":"Saporin-S6: a useful tool in cancer therapy","volume":"5","author":"Polito","year":"2013","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jaci.2017.06.028_bib58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.leukres.2016.02.010","article-title":"Treatment of CD30-positive systemic mastocytosis with brentuximab vedotin","volume":"44","author":"Borate","year":"2016","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2017.06.028_bibE1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/jpet.109.152439","article-title":"Eosinophil-selective binding and proapoptotic effect in\u00a0vitro of a synthetic Siglec-8 ligand, polymeric 6\u2032-sulfated sialyl Lewis x","volume":"330","author":"Hudson","year":"2009","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917311089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917311089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:13:28Z","timestamp":1758791608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917311089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0091674917311089"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.06.028","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}