{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:16:17Z","timestamp":1792088177078,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jaci.2017.07.036","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T02:46:57Z","timestamp":1504320417000},"page":"1002-1008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Efficacy and safety of 4\u00a0months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen\u2013related apple allergy"],"prefix":"10.1016","volume":"141","author":[{"given":"Tamar","family":"Kinaciyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Nagl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Faustmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Frommlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wolkersdorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-0007","authenticated-orcid":false,"given":"Stefan","family":"W\u00f6hrl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bastl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-7985","authenticated-orcid":false,"given":"Barbara","family":"Bohle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.07.036_bib1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/all.12666","article-title":"Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens","volume":"70","author":"Werfel","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1067\/mai.2002.128946","article-title":"Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22","volume":"110","author":"Kleine-Tebbe","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jaci.2010.10.027","article-title":"Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies","volume":"127","author":"Geroldinger-Simic","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0091-6749(98)70287-8","article-title":"Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells","volume":"102","author":"Fritsch","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib5","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1002\/eji.200324321","article-title":"Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level","volume":"33","author":"Bohle","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib6","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/j.1365-2222.2005.02332.x","article-title":"Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens","volume":"35","author":"Bohle","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jaci.2003.09.030","article-title":"Soybean\u00a0allergy in patients allergic to birch pollen: clinical investigation and\u00a0molecular characterization of allergens","volume":"113","author":"Mittag","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib8","first-page":"391","article-title":"Oral allergy syndrome successfully\u00a0treated with pollen immunotherapy","volume":"74","author":"Kelso","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib9","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1046\/j.1365-2222.1998.00399.x","article-title":"Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients","volume":"28","author":"Asero","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1034\/j.1398-9995.2003.00139.x","article-title":"How long does the effect of birch pollen injection SIT on apple allergy last?","volume":"58","author":"Asero","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1398-9995.2004.00561.x","article-title":"Effects of birch pollen SIT on apple allergy: a matter of dosage?","volume":"59","author":"Asero","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1365-2222.2004.1939.x","article-title":"Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges","volume":"34","author":"Bolhaar","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib13","first-page":"259","article-title":"Effect of hyposensitization for tree pollinosis on associated apple allergy","volume":"5","author":"Herrmann","year":"1995","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib14","first-page":"1007","article-title":"[Specific-pollen immunotherapy in the treatment of oral allergy syndrome in patients with tree pollen hypersensitivity]","volume":"59","author":"Modrzynski","year":"2002","journal-title":"Przegl Lek"},{"key":"10.1016\/j.jaci.2017.07.036_bib15","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1398-9995.2004.00626.x","article-title":"Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut","volume":"59","author":"Bucher","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/mnfr.200400037","article-title":"Food allergy to apple and specific immunotherapy with birch pollen","volume":"48","author":"Hansen","year":"2004","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jaci.2017.07.036_bib17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000323909","article-title":"Birch-apple syndrome treated with birch pollen immunotherapy","volume":"156","author":"Mauro","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaci.2010.08.021","article-title":"Effect of birch pollen-specific immunotherapy on birch pollen-related hazelnut allergy","volume":"127","author":"van Hoffen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jaci.2006.11.010","article-title":"Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1","volume":"119","author":"Kinaciyan","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1398-9995.2011.02744.x","article-title":"Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy","volume":"67","author":"Kopac","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jaci.2012.06.039","article-title":"Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy","volume":"131","author":"Geroldinger-Simic","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib22","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/all.12781","article-title":"Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy","volume":"71","author":"Kinaciyan","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib23","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jaci.2013.05.030","article-title":"Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen-associated apple allergy","volume":"132","author":"Kollmann","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib24","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1021\/jf060880m","article-title":"Effect of postharvest storage on the expression of the apple allergen Mal d 1","volume":"54","author":"Sancho","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaci.2017.07.036_bib25","doi-asserted-by":"crossref","first-page":"10548","DOI":"10.1021\/jf901938q","article-title":"Apple (Malus domestica L. Borkh.) allergen Mal d 1: effect of cultivar, cultivation system, and storage conditions","volume":"57","author":"Matthes","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jaci.2017.07.036_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1034\/j.1398-9995.2001.056002109.x","article-title":"Double-blind, placebo-controlled food challenge with apple","volume":"56","author":"Skamstrup Hansen","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/1471-2148-8-286","article-title":"The Bet v. 1 fold: an ancient, versatile\u00a0scaffold for binding of large, hydrophobic ligands","volume":"8","author":"Radauer","year":"2008","journal-title":"BMC Evol Biol"},{"key":"10.1016\/j.jaci.2017.07.036_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jaci.2012.11.011","article-title":"Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial","volume":"131","author":"Fleischer","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/cea.12901","article-title":"The clinical and immunological effects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions","volume":"47","author":"Gomez","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.07.036_bib30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2013.12.1088","article-title":"Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens","volume":"133","author":"Akdis","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.07.036_bib31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/all.12622","article-title":"Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients","volume":"70","author":"Nony","year":"2015","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917313593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917313593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:07:29Z","timestamp":1758791249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917313593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0091674917313593"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.07.036","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of 4\u00a0months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen\u2013related apple allergy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}