{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:27:19Z","timestamp":1786991239082,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jaci.2017.08.017","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T02:46:32Z","timestamp":1505097992000},"page":"1634-1645.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":127,"title":["Mesenchymal stem cells alleviate oxidative stress\u2013induced mitochondrial dysfunction in the airways"],"prefix":"10.1016","volume":"141","author":[{"given":"Xiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Michaeloudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen H.","family":"Wiegman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-7160","authenticated-orcid":false,"given":"Qizhou","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith C.W.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj K.","family":"Bhavsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.08.017_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1056\/NEJM200007273430407","article-title":"Chronic obstructive pulmonary disease","volume":"343","author":"Barnes","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib2","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib3","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","article-title":"The nature of small-airway obstruction in chronic obstructive pulmonary disease","volume":"350","author":"Hogg","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib4","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1183\/09031936.00018908","article-title":"Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction","volume":"31","author":"Chung","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2017.08.017_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejphar.2004.06.055","article-title":"Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays","volume":"497","author":"Jarai","year":"2004","journal-title":"Eur J Pharmacol"},{"issue":"suppl","key":"10.1016\/j.jaci.2017.08.017_bib6","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jaci.2004.04.041","article-title":"Synthetic responses in airway smooth muscle","volume":"114","author":"Howarth","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.08.017_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2466-9-25","article-title":"Persistence of oxidant and protease burden in the airways after smoking cessation","volume":"9","author":"Louhelainen","year":"2009","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib8","doi-asserted-by":"crossref","first-page":"329635","DOI":"10.1155\/2012\/329635","article-title":"Mitochondria-ros crosstalk in the control of cell death and aging","volume":"2012","author":"Marchi","year":"2012","journal-title":"J Signal Transduct"},{"key":"10.1016\/j.jaci.2017.08.017_bib9","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.08.017_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jaci.2015.01.046","article-title":"Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease","volume":"136","author":"Wiegman","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.08.017_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2017.08.017_bib12","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1096\/fj.14-268276","article-title":"Impaired\u00a0mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease","volume":"29","author":"Ahmad","year":"2015","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2017.08.017_bib13","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1172\/JCI74985","article-title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","volume":"124","author":"Mizumura","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.08.017_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nm.4021","article-title":"Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice","volume":"22","author":"Cloonan","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib15","doi-asserted-by":"crossref","first-page":"L889","DOI":"10.1152\/ajplung.00219.2012","article-title":"Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs","volume":"303","author":"Agarwal","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1513\/pats.201012-071DW","article-title":"Stem cells and cell therapies in lung biology and lung diseases","volume":"8","author":"Weiss","year":"2011","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2017.08.017_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/stem.1506","article-title":"Concise review: current status of stem cells and regenerative medicine in lung biology and diseases","volume":"32","author":"Weiss","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.jaci.2017.08.017_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1165\/rcmb.2013-0529OC","article-title":"Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage","volume":"51","author":"Li","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.08.017_bib19","doi-asserted-by":"crossref","first-page":"L537","DOI":"10.1152\/ajplung.2001.280.3.L537","article-title":"Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors","volume":"280","author":"Cho","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/CS20130039","article-title":"A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model","volume":"126","author":"Wiegman","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jaci.2017.08.017_bib21","doi-asserted-by":"crossref","first-page":"L691","DOI":"10.1152\/ajplung.00252.2010","article-title":"A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice","volume":"300","author":"Triantaphyllopoulos","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1124\/jpet.107.121624","article-title":"Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125","volume":"322","author":"Williams","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2017.08.017_bib23","doi-asserted-by":"crossref","first-page":"L295","DOI":"10.1152\/ajplung.00134.2010","article-title":"TGF-beta regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway\u00a0smooth muscle cells","volume":"300","author":"Michaeloudes","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bib24","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.109.898312","article-title":"Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice","volume":"121","author":"Lian","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2017.08.017_bib25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/toxsci\/kfr305","article-title":"The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells","volume":"125","author":"Lau","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jaci.2017.08.017_bib26","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.3727\/096368912X653020","article-title":"Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension","volume":"21","author":"Zhang","year":"2012","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jaci.2017.08.017_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20100102","article-title":"Emerging use of stem cells in regenerative medicine","volume":"428","author":"Teo","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.jaci.2017.08.017_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/jcmm.12962","article-title":"iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis\/proliferation imbalance in airway cells","volume":"21","author":"Li","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib29","doi-asserted-by":"crossref","first-page":"L840","DOI":"10.1152\/ajplung.00155.2013","article-title":"Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human\u00a0airway smooth muscle","volume":"306","author":"Aravamudan","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-7-53","article-title":"Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema","volume":"7","author":"Demedts","year":"2006","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2017.08.017_bib31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1073\/pnas.0510511103","article-title":"Mitochondrial transfer between cells can rescue aerobic respiration","volume":"103","author":"Spees","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.08.017_bib32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1093133","article-title":"Nanotubular highways for intercellular organelle transport","volume":"303","author":"Rustom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.08.017_bib34","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1089\/scd.2011.0691","article-title":"Vascular smooth muscle cells initiate proliferation of mesenchymal stem cells by mitochondrial transfer via tunneling nanotubes","volume":"21","author":"Vallabhaneni","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jaci.2017.08.017_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1479-5876-11-94","article-title":"Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance","volume":"11","author":"Pasquier","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.jaci.2017.08.017_bib36","first-page":"994","article-title":"Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy","volume":"33","author":"Ahmad","year":"2014","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2017.08.017_bib37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.stemcr.2016.08.009","article-title":"iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-alpha yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jaci.2017.08.017_bib38","first-page":"799","article-title":"High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a\u00a0randomized, placebo-controlled trial","volume":"11","author":"Johnson","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jaci.2017.08.017_bib39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1513\/pats.200504-028SR","article-title":"The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease","volume":"2","author":"Chung","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaci.2017.08.017_bibE1","doi-asserted-by":"crossref","first-page":"L295","DOI":"10.1152\/ajplung.00134.2010","article-title":"TGF-beta regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells","volume":"300","author":"Michaeloudes","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bibE2","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.109.898312","article-title":"Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice","volume":"121","author":"Lian","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2017.08.017_bibE3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/toxsci\/kfr305","article-title":"The role of MAPK and Nrf2\u00a0pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells","volume":"125","author":"Lau","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jaci.2017.08.017_bibE4","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1124\/mol.105.012591","article-title":"Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance","volume":"68","author":"Walters","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jaci.2017.08.017_bibE5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pupt.2007.07.001","article-title":"Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle","volume":"21","author":"Oltmanns","year":"2008","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jaci.2017.08.017_bibE6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1165\/rcmb.2013-0529OC","article-title":"Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage","volume":"51","author":"Li","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.08.017_bibE7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1164\/rccm.201503-0593OC","article-title":"Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin","volume":"193","author":"Mitani","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.08.017_bibE8","doi-asserted-by":"crossref","first-page":"L840","DOI":"10.1152\/ajplung.00155.2013","article-title":"Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human\u00a0airway smooth muscle","volume":"306","author":"Aravamudan","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaci.2017.08.017_bibE9","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.3727\/096368912X653020","article-title":"Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension","volume":"21","author":"Zhang","year":"2012","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jaci.2017.08.017_bibE10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/CS20130039","article-title":"A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model","volume":"126","author":"Wiegman","year":"2014","journal-title":"Clin Sci"},{"key":"10.1016\/j.jaci.2017.08.017_bibE11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.stemcr.2016.08.009","article-title":"iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-alpha yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem Cell Rep"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917314318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917314318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:12:57Z","timestamp":1758791577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917314318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0091674917314318"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.08.017","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cells alleviate oxidative stress\u2013induced mitochondrial dysfunction in the airways","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}