{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:23Z","timestamp":1790050703470,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jaci.2017.10.033","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T15:17:04Z","timestamp":1511709424000},"page":"618-629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dual loss of p110\u03b4 PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features"],"prefix":"10.1016","volume":"142","author":[{"given":"Nigel","family":"Sharfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Karanxha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjit","family":"Dadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Merico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chitayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Anne","family":"Herbrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Grinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim M.","family":"Roifman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.10.033_bib1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1399-0004.2009.01239.x","article-title":"Combined immunodeficiency, facial dysmorphism, optic nerve atrophy, skeletal anomalies and developmental delay: a new syndrome","volume":"76","author":"Roifman","year":"2009","journal-title":"Clin Genet"},{"key":"10.1016\/j.jaci.2017.10.033_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jaci.2012.04.029","article-title":"Defining combined immunodeficiency","volume":"130","author":"Roifman","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib3","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jaci.2013.09.044","article-title":"Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience","volume":"133","author":"Shearer","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s10875-015-0201-1","article-title":"Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015","volume":"35","author":"Picard","year":"2015","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/nyas.12027","article-title":"Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity","volume":"1280","author":"Okkenhaug","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaci.2017.10.033_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tibs.2005.02.008","article-title":"Signalling by PI3K isoforms: insights from gene-targeted mice","volume":"30","author":"Vanhaesebroeck","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jaci.2017.10.033_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/oxfordjournals.jbchem.a003126","article-title":"Phosphoinositide 3-kinases in immunity: lessons from knockout mice","volume":"131","author":"Sasaki","year":"2002","journal-title":"J Biochem"},{"key":"10.1016\/j.jaci.2017.10.033_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(97)01061-X","article-title":"Phosphoinositide 3-kinases: a conserved family of signal transducers","volume":"22","author":"Vanhaesebroeck","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jaci.2017.10.033_bib9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1126\/science.1243292","article-title":"Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage","volume":"342","author":"Angulo","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.10.033_bib10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s10875-014-0012-9","article-title":"Mutations in PIK3CD can cause hyper IgM syndrome (HIGM) associated with increased cancer susceptibility","volume":"34","author":"Crank","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jaci.2016.03.022","article-title":"Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase delta syndrome 2: a cohort study","volume":"138","author":"Elkaim","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ni.2771","article-title":"Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency","volume":"15","author":"Lucas","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1083\/jcb.201008023","article-title":"The astrin-kinastrin\/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment","volume":"192","author":"Dunsch","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib14","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.4161\/cc.8.17.9514","article-title":"SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition","volume":"8","author":"Fang","year":"2009","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.jaci.2017.10.033_bib15","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1074\/jbc.M111.277194","article-title":"CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis","volume":"287","author":"Huang","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.033_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.201006129","article-title":"Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores","volume":"191","author":"Schmidt","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib17","doi-asserted-by":"crossref","first-page":"39380","DOI":"10.1074\/jbc.M112.406652","article-title":"Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.033_bib18","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng.3091","article-title":"Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma","volume":"46","author":"Lee","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2017.10.033_bib19","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1242\/jcs.114.15.2879","article-title":"Phosphorylation of MAP4 affects microtubule properties and cell cycle progression","volume":"114","author":"Chang","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jaci.2017.10.033_bib20","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0960-9822(02)00897-7","article-title":"MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells","volume":"12","author":"Holmfeldt","year":"2002","journal-title":"Curr Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib21","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1074\/jbc.271.18.10834","article-title":"Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark: phosphorylation sites and regulation of microtubule dynamics","volume":"271","author":"Illenberger","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.033_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1083\/jcb.128.5.849","article-title":"Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics","volume":"128","author":"Ookata","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib23","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1021\/cb200403x","article-title":"Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4","volume":"7","author":"Xiao","year":"2012","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nrm3227","article-title":"Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions","volume":"12","author":"Janke","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tcb.2014.10.004","article-title":"Post-translational modifications of tubulin: pathways to functional diversity of microtubules","volume":"25","author":"Song","year":"2015","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cm.21290","article-title":"The emerging role of the\u00a0tubulin code: from the tubulin molecule to neuronal function and disease","volume":"73","author":"Chakraborti","year":"2016","journal-title":"Cytoskeleton (Hoboken, NJ)"},{"key":"10.1016\/j.jaci.2017.10.033_bib27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.15252\/embj.201593071","article-title":"Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility","volume":"35","author":"McKenney","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2017.10.033_bib28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cellsig.2010.10.014","article-title":"The ins and outs of tubulin acetylation: more than just a post-translational modification?","volume":"23","author":"Perdiz","year":"2011","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaci.2017.10.033_bib29","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.cub.2006.09.014","article-title":"Microtubule acetylation promotes kinesin-1 binding and transport","volume":"16","author":"Reed","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ncb2920","article-title":"Regulation of microtubule motors by tubulin isotypes and post-translational modifications","volume":"16","author":"Sirajuddin","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib31","doi-asserted-by":"crossref","first-page":"e51677","DOI":"10.1371\/journal.pone.0051677","article-title":"Human natural killer cell maturation defect supports in\u00a0vivo CD56(bright) to CD56(dim) lineage development","volume":"7","author":"Domaica","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.10.033_bib32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset","volume":"126","author":"Poli","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2017.10.033_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1479-5876-7-93","article-title":"Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous Toll-like receptor 9 stimulation","volume":"7","author":"Carpenter","year":"2009","journal-title":"J Transl Med"},{"key":"10.1016\/j.jaci.2017.10.033_bib34","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1182\/blood-2006-03-008441","article-title":"CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells","volume":"109","author":"Huggins","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.10.033_bib35","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1182\/blood-2009-07-235960","article-title":"An in\u00a0vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization","volume":"114","author":"Jourdan","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.10.033_bib36","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.4049\/jimmunol.0800933","article-title":"B cell receptor and BAFF receptor signaling regulation of B cell homeostasis","volume":"183","author":"Khan","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib37","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1073\/pnas.0903543106","article-title":"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans","volume":"106","author":"Warnatz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.033_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.1102321","article-title":"Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors","volume":"188","author":"Kreuzaler","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib39","first-page":"233","article-title":"Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency","volume":"21","author":"Jin","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jaci.2017.10.033_bib40","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1073\/pnas.90.12.5838","article-title":"Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1","volume":"90","author":"Cabanas","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.033_bib41","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1083\/jcb.116.6.1527","article-title":"Interaction of leukocyte integrins with ligand is necessary but not sufficient for function","volume":"116","author":"Dransfield","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1083\/jcb.116.1.219","article-title":"Divalent cation regulation of the function of the leukocyte integrin LFA-1","volume":"116","author":"Dransfield","year":"1992","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib43","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/j.1460-2075.1989.tb08552.x","article-title":"Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits","volume":"8","author":"Dransfield","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2017.10.033_bib44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.20020805","article-title":"A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation","volume":"196","author":"Clayton","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.10.033_bib45","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1128\/MCB.22.24.8580-8591.2002","article-title":"Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex","volume":"22","author":"Jou","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.033_bib46","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1073560","article-title":"Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice","volume":"297","author":"Okkenhaug","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.10.033_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.20112533","article-title":"Agammaglobulinemia and absent B lineage cells in a patient lacking the p85alpha subunit of PI3K","volume":"209","author":"Conley","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.10.033_bib48","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.4049\/jimmunol.177.8.5122","article-title":"The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells","volume":"177","author":"Okkenhaug","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib49","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1073\/pnas.0808594106","article-title":"p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease","volume":"106","author":"Saudemont","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.033_bib50","first-page":"673","article-title":"Idenification of a phosphoinositide-3 kinase (PI-3K) p110\u03b4 (PIK3CD) deficient individual","volume":"33","author":"Zhang","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib51","doi-asserted-by":"crossref","first-page":"e92712","DOI":"10.1371\/journal.pone.0092712","article-title":"Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19)","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2017.10.033_bib52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/09537100400016711","article-title":"Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets","volume":"16","author":"Senis","year":"2005","journal-title":"Platelets"},{"key":"10.1016\/j.jaci.2017.10.033_bib53","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1038\/ncomms5778","article-title":"Actin-microtubule coordination at growing microtubule ends","volume":"5","author":"Preciado Lopez","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2017.10.033_bib54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/jb\/mvr119","article-title":"Microtubule-associated protein 4 binds to actin filaments and modulates their properties","volume":"151","author":"Matsushima","year":"2012","journal-title":"J Biochem"},{"key":"10.1016\/j.jaci.2017.10.033_bib55","doi-asserted-by":"crossref","first-page":"23766","DOI":"10.1074\/jbc.M115.673517","article-title":"Signaling scaffold protein IQGAP1 interacts with microtubule plus-end tracking protein SKAP and links dynamic microtubule plus-end to steer cell migration","volume":"290","author":"Cao","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.033_bib56","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.4049\/jimmunol.1200242","article-title":"Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells","volume":"188","author":"Filbert","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.033_bib57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/humu.22711","article-title":"MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation","volume":"36","author":"Zahnleiter","year":"2015","journal-title":"Hum Mut"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917318146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917318146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:14:29Z","timestamp":1758791669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917318146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0091674917318146"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.033","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual loss of p110\u03b4 PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}