{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:25:53Z","timestamp":1790411153582,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jaci.2017.10.044","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T22:04:24Z","timestamp":1513807464000},"page":"1066-1079.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Low-density lipoprotein receptor\u2013related protein 1 attenuates house dust mite\u2013induced eosinophilic airway inflammation by suppressing dendritic cell\u2013mediated adaptive immune responses"],"prefix":"10.1016","volume":"142","author":[{"given":"Amarjit","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann","family":"Kaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie A.","family":"Cuento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha V.","family":"Barochia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Dagur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Philip","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Keeran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Jeffries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Xi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart J.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.10.044_bib1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI200113992","article-title":"LRP: a multifunctional scavenger and signaling receptor","volume":"108","author":"Herz","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.10.044_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1152\/physrev.00033.2007","article-title":"LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies","volume":"88","author":"Lillis","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaci.2017.10.044_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.matbio.2009.08.003","article-title":"LRP1 regulates remodeling of the extracellular matrix by fibroblasts","volume":"29","author":"Gaultier","year":"2010","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jaci.2017.10.044_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.bi.63.070194.003125","article-title":"Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (Lrp)","volume":"63","author":"Krieger","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jaci.2017.10.044_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2014.00093","article-title":"The low-density lipoprotein receptor-related protein 1 and\u00a0amyloid-beta clearance in Alzheimer's disease","volume":"6","author":"Kanekiyo","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jaci.2017.10.044_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2010.09.018","article-title":"Signaling through LRP1: protection from atherosclerosis and beyond","volume":"81","author":"Boucher","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jaci.2017.10.044_bib7","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1073\/pnas.1515480113","article-title":"LDL receptor-related protein-1 regulates NF\u03baB and microRNA-155 in macrophages to control the inflammatory response","volume":"113","author":"Mantuano","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.044_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajpath.2013.08.029","article-title":"LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system","volume":"184","author":"Gonias","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2017.10.044_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1165\/rcmb.2011-0071OC","article-title":"Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells","volume":"46","author":"Tucker","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.10.044_bib10","doi-asserted-by":"crossref","first-page":"18504","DOI":"10.1074\/jbc.M410265200","article-title":"Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta)","volume":"280","author":"Takayama","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.044_bib11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1158\/0008-5472.CAN-08-3379","article-title":"Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9","volume":"69","author":"Song","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2017.10.044_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1082095","article-title":"LRP: Role in vascular wall integrity and protection from atherosclerosis","volume":"300","author":"Boucher","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.10.044_bib13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.RES.0000260204.40510.aa","article-title":"Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse","volume":"100","author":"Overton","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2017.10.044_bib14","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1182\/blood-2013-06-510875","article-title":"The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta(2) integrins (CD11\/CD18)","volume":"123","author":"Weckbach","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.10.044_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MOL.0b013e32835e809c","article-title":"The low-density lipoprotein receptor-related protein 1 in inflammation","volume":"24","author":"May","year":"2013","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jaci.2017.10.044_bib16","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1182\/blood-2007-12-127613","article-title":"Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappa B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor","volume":"111","author":"Gaultier","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.10.044_bib17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00441-013-1699-2","article-title":"Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages","volume":"354","author":"May","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jaci.2017.10.044_bib18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12974-016-0772-7","article-title":"LRP1 modulates the microglial immune response via regulation of JNK and NF-\u03baB signaling pathways","volume":"13","author":"Yang","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jaci.2017.10.044_bib19","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI72051","article-title":"An AXL\/LRP-1\/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in\u00a0vivo","volume":"124","author":"Subramanian","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.10.044_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/77835","article-title":"CD91: a receptor for heat shock protein gp96","volume":"1","author":"Binder","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncomms1524","article-title":"CD91-dependent programming of T-helper cell responses following heat shock protein immunization","volume":"2","author":"Pawaria","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2017.10.044_bib22","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.4049\/jimmunol.172.9.5277","article-title":"Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages","volume":"172","author":"Tobian","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(03)00758-X","article-title":"By binding SIRP alpha or calreticulin\/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation","volume":"115","author":"Gardai","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2017.10.044_bib24","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1164\/rccm.201002-0308OC","article-title":"Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway","volume":"182","author":"Yao","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib25","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.4049\/jimmunol.1301234","article-title":"The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses","volume":"192","author":"Fredriksson","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib26","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3 and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"Dzionek","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib27","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1038\/ncomms7224","article-title":"Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase","volume":"6","author":"Mishra","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2017.10.044_bib28","doi-asserted-by":"crossref","first-page":"19857","DOI":"10.1073\/pnas.0810713105","article-title":"The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors","volume":"105","author":"D'Alise","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.044_bib29","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1304048","article-title":"Dupilumab in persistent asthma with elevated eosinophil levels","volume":"368","author":"Wenzel","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib30","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1056\/NEJMoa1106469","article-title":"Lebrikizumab treatment in adults with asthma","volume":"365","author":"Corren","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib31","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2017.10.044_bib33","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.201208-1414OC","article-title":"Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study","volume":"187","author":"Hanania","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib34","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/cea.12345","article-title":"Full blood count parameters for the detection of asthma inflammatory phenotypes","volume":"44","author":"Zhang","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.10.044_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/thoraxjnl-2014-206069","article-title":"Asthma biomarkers: what constitutes a \u2018gold standard\u2019?","volume":"70","author":"Arron","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2017.10.044_bib36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2017.10.044_bib37","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4049\/jimmunol.182.1.623","article-title":"CD11b(+) Myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation","volume":"182","author":"Medoff","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4049\/jimmunol.1502393","article-title":"Dectin-1 plays\u00a0an important role in house dust mite-induced allergic airway inflammation through the activation of CD11b(+) dendritic cells","volume":"198","author":"Ito","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/mi.2013.74","article-title":"Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation","volume":"7","author":"Clarke","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nri723","article-title":"C-type lectin receptors on dendritic cells and Langerhans cells","volume":"2","author":"Figdor","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri.2016.55","article-title":"C-type lectin receptors in the control of T helper cell differentiation","volume":"16","author":"Geijtenbeek","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib42","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.20042311","article-title":"In\u00a0vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma","volume":"201","author":"van Rijt","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib43","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1084\/jem.188.11.2019","article-title":"Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity","volume":"188","author":"Stumbles","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib44","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1084\/jem.20101563","article-title":"Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen","volume":"207","author":"Hammad","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4049\/jimmunol.172.1.70","article-title":"A CD91-positive subset of CD11c(+) blood dendritic cells: Characterization of the APC that functions to enhance adaptive\u00a0immune responses against CD91-targeted antigens","volume":"172","author":"Hart","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib46","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.4049\/jimmunol.181.9.6525","article-title":"Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses","volume":"181","author":"De Filippo","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib47","doi-asserted-by":"crossref","first-page":"20847","DOI":"10.1074\/jbc.M200425200","article-title":"The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2\/4 pathway","volume":"277","author":"Vabulas","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.044_bib48","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.jaci.2012.03.012","article-title":"STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children","volume":"129","author":"Hancock","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib49","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.4049\/jimmunol.152.4.1538","article-title":"Adjuvant-free in-vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation","volume":"152","author":"Chu","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib50","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0264-410X(01)00361-9","article-title":"Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity","volume":"20","author":"Cianciolo","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2017.10.044_bib51","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","article-title":"CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin","volume":"14","author":"Basu","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2017.10.044_bib52","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/intimm\/12.11.1539","article-title":"Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway","volume":"12","author":"Basu","year":"2000","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib54","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12890-016-0263-8","article-title":"Burden of asthma with elevated blood eosinophil levels","volume":"16","author":"Casciano","year":"2016","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib55","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jaci.2003.09.011","article-title":"Human dendritic cell 1 and dendritic cell 2 subsets express Fc\u03b5RI: correlation with serum IgE and allergic asthma","volume":"112","author":"Foster","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib56","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI116283","article-title":"Regulation of macrophage alpha 2-macroglobulin receptor\/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma","volume":"91","author":"LaMarre","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.10.044_bib57","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1165\/rcmb.2007-0025OC","article-title":"Smoking alters alveolar macrophage recognition and phagocytic ability","volume":"37","author":"Hodge","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.10.044_bib58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib59","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1172\/JCI119234","article-title":"Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice","volume":"99","author":"Mould","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.10.044_bib60","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2017.10.044_bib61","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.4049\/jimmunol.172.6.3842","article-title":"CD4(+)CD25(+) T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype","volume":"172","author":"Jaffar","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib62","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.4049\/jimmunol.170.11.5502","article-title":"Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity","volume":"170","author":"Hadeiba","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/1074-7613(95)90032-2","article-title":"B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4","volume":"2","author":"Freeman","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2017.10.044_bib64","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1165\/ajrcmb.16.3.9070619","article-title":"Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L","volume":"16","author":"Masten","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.10.044_bib65","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/nm.2920","article-title":"The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens","volume":"18","author":"Wilson","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib66","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.4049\/jimmunol.173.11.7003","article-title":"NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness","volume":"173","author":"Poynter","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib67","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1164\/rccm.201002-0308OC","article-title":"Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway","volume":"182","author":"Yao","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib68","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1165\/rcmb.2013-0001OC","article-title":"Peptidoglycan recognition protein 1 promotes house dust mite-induced airway inflammation in mice","volume":"49","author":"Yao","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.10.044_bib69","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1164\/ajrccm.157.1.9703002","article-title":"Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma","volume":"157","author":"Crimi","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.10.044_bib70","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.4049\/jimmunol.172.11.7095","article-title":"Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model","volume":"172","author":"Ishii","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bib71","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.100118997","article-title":"IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization","volume":"97","author":"Makela","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2017.10.044_bib72","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N Engl J Med"},{"issue":"suppl\u00a05","key":"10.1016\/j.jaci.2017.10.044_bib73","doi-asserted-by":"crossref","first-page":"S236","DOI":"10.1513\/AnnalsATS.201405-218AW","article-title":"Dendritic cell and epithelial cell interactions at the origin of murine asthma","volume":"119","author":"Lambrecht","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jaci.2017.10.044_bib74","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1074-7613(02)00276-5","article-title":"A\u00a0restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure","volume":"16","author":"Julia","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2017.10.044_bib75","doi-asserted-by":"crossref","first-page":"e53242","DOI":"10.1371\/journal.pone.0053242","article-title":"Resident CD11b(+)Ly6C(\u2212) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice","volume":"7","author":"Mesnil","year":"2012","journal-title":"PLos One"},{"key":"10.1016\/j.jaci.2017.10.044_bib76","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1074\/jbc.M406037200","article-title":"Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation","volume":"280","author":"Pope","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2017.10.044_bib77","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4049\/jimmunol.169.3.1524","article-title":"Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7","volume":"169","author":"Hammad","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2017.10.044_bibE1","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1038\/ncomms7224","article-title":"Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase","volume":"6","author":"Mishra","year":"2015","journal-title":"Nat Commun"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917329238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674917329238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:12:47Z","timestamp":1758791567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674917329238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0091674917329238"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.044","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-density lipoprotein receptor\u2013related protein 1 attenuates house dust mite\u2013induced eosinophilic airway inflammation by suppressing dendritic cell\u2013mediated adaptive immune responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}