{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:32:59Z","timestamp":1793277179223,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jaci.2017.10.046","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T23:24:28Z","timestamp":1515194668000},"page":"1298-1309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2\u2013high atopic dermatitis disease endotype"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-6252","authenticated-orcid":false,"given":"Nathan","family":"Dyjack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Goleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cydney","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Eui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-0106","authenticated-orcid":false,"given":"Lianghua","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bronchick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton F.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Richers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A.","family":"Seibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald Y.M.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2017.10.046_bib1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2310\/6620.2007.06034","article-title":"A population-based survey of eczema prevalence in the United States","volume":"18","author":"Hanifin","year":"2007","journal-title":"Dermatitis"},{"key":"10.1016\/j.jaci.2017.10.046_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/DER.0000000000000034","article-title":"Associations of childhood eczema severity: a US population-based study","volume":"25","author":"Silverberg","year":"2014","journal-title":"Dermatitis"},{"key":"10.1016\/j.jaci.2017.10.046_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jaci.2014.08.008","article-title":"Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches","volume":"134","author":"Leung","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2017.10.046_bib4","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2017.10.046_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jaci.2006.05.004","article-title":"Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations","volume":"118","author":"Weidinger","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.07.034","article-title":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","volume":"124","author":"Gao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ng.3424","article-title":"Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis","volume":"47","author":"Paternoster","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2017.10.046_bib9","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jaci.2010.03.016","article-title":"Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum","volume":"125","author":"Gao","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib10","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.jaci.2014.03.003","article-title":"Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology","volume":"133","author":"Khattri","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jaci.2014.08.005","article-title":"Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention","volume":"134","author":"Simpson","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib12","first-page":"902359","article-title":"Twin studies of atopic dermatitis: interpretations and applications in the filaggrin era","volume":"2015","author":"Elmose","year":"2015","journal-title":"J Allergy (Cairo)"},{"issue":"suppl","key":"10.1016\/j.jaci.2017.10.046_bib13","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jaci.2017.01.008","article-title":"Clinical phenotypes and endophenotypes of atopic dermatitis: where are we, and where should we go?","volume":"139","author":"Bieber","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1056\/NEJMoa1314768","article-title":"Dupilumab treatment in adults with moderate-to-severe atopic dermatitis","volume":"371","author":"Beck","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.046_bib15","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa1610020","article-title":"Two phase 3 trials of dupilumab versus placebo in atopic dermatitis","volume":"375","author":"Simpson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2017.10.046_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12920-015-0133-x","article-title":"Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways","volume":"8","author":"Ewald","year":"2015","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jaci.2017.10.046_bib17","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2015.03.003","article-title":"RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications","volume":"135","author":"Suarez-Farinas","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib18","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jaci.2010.12.1124","article-title":"Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities","volume":"127","author":"Suarez-Farinas","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaci.2014.04.021","article-title":"Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis","volume":"134","author":"Cole","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1165\/rcmb.2015-0274MA","article-title":"Airway progenitor clone formation is enhanced by Y-27632-dependent changes in the transcriptome","volume":"55","author":"Reynolds","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2017.10.046_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2017.10.046_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","article-title":"Orchestrating high-throughput genomic analysis with Bioconductor","volume":"12","author":"Huber","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2017.10.046_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2017.10.046_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jaci.2017.10.046_bib25","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1093\/bioinformatics\/btm369","article-title":"GSEA-P: a desktop application for Gene Set Enrichment Analysis","volume":"23","author":"Subramanian","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2017.10.046_bib26","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2017.10.046_bib27","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2017.10.046_bib28","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1210\/me.2010-0215","article-title":"Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells","volume":"24","author":"Szeles","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jaci.2017.10.046_bib29","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1182\/blood-2012-02-410241","article-title":"Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells","volume":"120","author":"Hutter","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2017.10.046_bib30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaci.2013.11.025","article-title":"Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease","volume":"133","author":"Poole","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fphar.2016.00299","article-title":"Cysteinyl leukotrienes pathway genes, atopic asthma and drug response: from population isolates to large genome-wide association studies","volume":"7","author":"Thompson","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaci.2017.10.046_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2017.10.046_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/ng.2438","article-title":"Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population","volume":"44","author":"Hirota","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2017.10.046_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.278.5335.106","article-title":"Negative regulation by HLA-DO of MHC class II-restricted antigen processing","volume":"278","author":"Denzin","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jaci.2017.10.046_bib35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2072","article-title":"New developments in FcepsilonRI regulation, function and inhibition","volume":"7","author":"Kraft","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaci.2014.10.037","article-title":"Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection","volume":"135","author":"Esaki","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib37","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jaci.2003.08.049","article-title":"Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis","volume":"112","author":"Nomura","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","article-title":"Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2017.10.046_bib39","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1111\/bjd.15409","article-title":"Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis","volume":"177","author":"Li","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2017.10.046_bib40","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1186\/s12864-015-2270-1","article-title":"Comprehensive evaluation of AmpliSeq transcriptome, a novel targeted whole transcriptome RNA sequencing methodology for global gene expression analysis","volume":"16","author":"Li","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jaci.2017.10.046_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2133.2009.09467.x","article-title":"A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis","volume":"162","author":"Harper","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2017.10.046_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000312669","article-title":"Cysteinyl leukotrienes and their receptors: molecular and functional characteristics","volume":"85","author":"Singh","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.jaci.2017.10.046_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.alit.2014.09.001","article-title":"The role of leukotrienes in allergic diseases","volume":"64","author":"Liu","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2017.10.046_bib44","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.mce.2016.09.014","article-title":"Loss of DRO1\/CCDC80 results in obesity and promotes adipocyte differentiation","volume":"439","author":"Grill","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jaci.2017.10.046_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fphar.2016.00142","article-title":"Comparative transcriptome analysis identifies CCDC80 as a novel gene associated with pulmonary arterial hypertension","volume":"7","author":"Sasagawa","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaci.2017.10.046_bib46","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/all.13223","article-title":"Non-lesional atopic dermatitis skin shares similar T-cell clones with lesional tissues","volume":"72","author":"Brunner","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.10.046_bib47","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaci.2014.08.001","article-title":"Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis","volume":"134","author":"Yoshida","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12016-010-8224-0","article-title":"Role of dendritic cells in atopic dermatitis: an update","volume":"41","author":"Bieber","year":"2011","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib49","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jaci.2007.03.006","article-title":"Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis","volume":"119","author":"Guttman-Yassky","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.10.046_bib50","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2017.10.046_bib51","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jaci.2014.10.013","article-title":"Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis","volume":"134","author":"Hamilton","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918300010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918300010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:10:43Z","timestamp":1758791443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918300010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0091674918300010"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.046","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2\u2013high atopic dermatitis disease endotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.10.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}