{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:01:33Z","timestamp":1778122893806,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jaci.2017.11.066","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T22:38:44Z","timestamp":1520289524000},"page":"1570-1577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nasal and ocular challenges"],"prefix":"10.1016","volume":"141","author":[{"given":"Amber N.","family":"Pepper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-7075","authenticated-orcid":false,"given":"Dennis K.","family":"Ledford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl\u00a03","key":"10.1016\/j.jaci.2017.11.066_bib1","first-page":"S1","article-title":"Allergy diagnostic testing: an updated practice parameter","volume":"100","author":"Bernstein","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib2","series-title":"Middleton's allergy: principles and practice","first-page":"652","article-title":"Nasal provocation testing","author":"Scadding","year":"2014"},{"key":"10.1016\/j.jaci.2017.11.066_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/all.12986","article-title":"Conjunctival allergen provocation test: guidelines for daily practice","volume":"72","author":"Fauquert","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4193\/Rhino11.252","article-title":"Executive summary of European Task Force document on diagnostic tools in rhinology","volume":"50","author":"Hellings","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2017.11.066_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.anai.2014.06.018","article-title":"Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician","volume":"113","author":"Soliman","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib6","first-page":"1","article-title":"Allergen-specific nasal provocation testing: review by the rhinoconjunctivitis committee of the Spanish Society of Allergy and Clinical Immunology","volume":"21","author":"Dordal","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1081-1206(10)62478-7","article-title":"Nasal provocation testing: a review","volume":"86","author":"Litvyakova","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib8","series-title":"Allergic rhinitis","first-page":"153","article-title":"Nasal provocation test in the diagnosis of allergic rhinitis","author":"Loureiro","year":"2012"},{"key":"10.1016\/j.jaci.2017.11.066_bib9","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/all.13133","article-title":"Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future\u2014an EAACI Position Paper","volume":"72","author":"Pfaar","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.iac.2015.12.008","article-title":"Local allergic rhinitis","volume":"36","author":"Campo","year":"2016","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2017.11.066_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40413-016-0126-z","article-title":"Local allergic rhinitis: entopy or spontaneous response?","volume":"9","author":"Gelardi","year":"2016","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaci.2017.11.066_bib12","first-page":"396","article-title":"Nasal hyperreactivity: nonspecific nasal provocation tests. Review by the Rhinoconjunctivitis Committee of the Spanish Society of Allergy and Clinical Immunology","volume":"25","author":"Lluch-Bernal","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib13","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1046\/j.1365-2222.2000.00923.x","article-title":"Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement","volume":"30","author":"Koskela","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib14","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jaci.2016.08.025","article-title":"Validation of the Global Allergy and Asthma European Network (GA2LEN) chamber for trials in allergy: innovation of a mobile allergen exposure chamber","volume":"139","author":"Zuberbier","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib15","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1398-9995.2007.01409.x","article-title":"EAACI\/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity","volume":"62","author":"Nizankowska-Mogilnicka","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib16","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11882-014-0508-7","article-title":"Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD)","volume":"15","author":"Simon","year":"2015","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2017.11.066_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1034\/j.1398-9995.2002.t01-1-13447.x","article-title":"Nasal provocation test (NPT) with aspirin: a sensitive and safe method to diagnose aspirin-induced asthma (AIA)","volume":"57","author":"Alonso-Llamazares","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1081-1206(10)60012-9","article-title":"Intranasal ketorolac challenge for the diagnosis of aspirin-exacerbated respiratory disease","volume":"97","author":"White","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/thorax.55.11.921","article-title":"Intranasal challenge with aspirin in the diagnosis of aspirin intolerant asthma: evaluation of nasal response by acoustic rhinometry","volume":"55","author":"Casadevall","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2017.11.066_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.anai.2010.05.020","article-title":"Use of intranasal ketorolac and modified oral aspirin challenge for desensitization of aspirin-exacerbated respiratory disease","volume":"105","author":"Lee","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1398-9995.2011.02590.x","article-title":"How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement","volume":"66","author":"Bousquet","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jaci.2014.10.045","article-title":"Environmental exposure chambers in allergen immunotherapy trials: current status and clinical validation needs","volume":"135","author":"Rosner-Friese","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.anai.2013.07.019","article-title":"Environmental exposure unit: a sensitive, specific, and reproducible methodology for allergen challenge","volume":"111","author":"Ellis","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaci.2012.03.031","article-title":"Responses to ragweed pollen in a pollen challenge chamber versus seasonal exposure identify allergic rhinoconjunctivitis endotypes","volume":"130","author":"Jacobs","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1365-2222.2010.03498.x","article-title":"Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions","volume":"40","author":"Hohlfeld","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archopht.1990.01070030090035","article-title":"Conjunctival allergen challenge. A\u00a0clinical approach to studying allergic conjunctivitis","volume":"108","author":"Abelson","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jaci.2017.11.066_bib27","author":"Glacy"},{"key":"10.1016\/j.jaci.2017.11.066_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13223-015-0082-0","article-title":"The Allergic Rhinitis\u2013Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies","volume":"11","author":"Ellis","year":"2015","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib29","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jaip.2016.02.006","article-title":"Minimal clinically important difference (MCID) in allergic rhinitis: Agency for Healthcare Research and Quality or anchor-based thresholds?","volume":"4","author":"Meltzer","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2017.11.066_bib30","doi-asserted-by":"crossref","first-page":"E213","DOI":"10.1002\/lary.24590","article-title":"Nasal nitric oxide is dependent on sinus obstruction in allergic rhinitis","volume":"124","author":"Suojalehto","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2017.11.066_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.exer.2013.07.019","article-title":"Allergy and allergic mediators in tears","volume":"117","author":"Leonardi","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jaci.2017.11.066_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.aller.2010.01.007","article-title":"Can conjunctival provocation test facilitate the diagnosis of food allergy in children?","volume":"38","author":"Krane Kvenshagen","year":"2010","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaci.2017.11.066_bib33","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/cea.12899","article-title":"Conjunctival provocation test in diagnosis of peanut allergy in children","volume":"47","author":"Lindvik","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2017.11.066_bib34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0091-6749(96)80022-4","article-title":"Improving the safety of conjunctival provocation tests","volume":"98","author":"Anderson","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2017.11.066_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2147\/OPTH.S38732","article-title":"Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy","volume":"7","author":"Gomes","year":"2013","journal-title":"Clin Ophthalmol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:09:17Z","timestamp":1758791357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918303014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0091674918303014"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2017.11.066","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasal and ocular challenges","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2017.11.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}