{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:07:26Z","timestamp":1792822046517,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jaci.2018.01.038","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T20:56:30Z","timestamp":1519073790000},"page":"1894-1908.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation"],"prefix":"10.1016","volume":"142","author":[{"given":"Hector","family":"Rodriguez Cetina Biefer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Heinbokel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqi","family":"Nian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Koduru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"El Fatimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionita","family":"Ghiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Trachtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhito","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan G.","family":"Tullius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Elkhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.01.038_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0167-5699(97)80008-4","article-title":"The discovery of MHC restriction","volume":"18","author":"Zinkernagel","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaci.2018.01.038_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.iy.02.040184.000411","article-title":"The major histocompatibility complex-restricted antigen receptor on T cells","volume":"2","author":"Haskins","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib4","first-page":"283","article-title":"Structure, assembly and intracellular transport of the T cell receptor for antigen","volume":"3","author":"Exley","year":"1991","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/251547a0","article-title":"Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis","volume":"251","author":"Zinkernagel","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/248701a0","article-title":"Restriction of in\u00a0vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system","volume":"248","author":"Zinkernagel","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20030795","article-title":"MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major","volume":"199","author":"Lemos","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2018.01.038_bib8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nri3754","article-title":"Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?","volume":"14","author":"Kambayashi","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In\u00a0vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2018.01.038_bib10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib13","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jaci.2018.01.038_bib14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/bcmd.1998.0201","article-title":"Genetic\u00a0and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region","volume":"24","author":"Poltorak","year":"1998","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.jaci.2018.01.038_bib15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1146\/annurev.immunol.26.021607.090320","article-title":"The master switch: the role of mast cells in autoimmunity and tolerance","volume":"26","author":"Sayed","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib17","doi-asserted-by":"crossref","first-page":"e1002619","DOI":"10.1371\/journal.ppat.1002619","article-title":"The role of mast cells in the defence against pathogens","volume":"8","author":"Urb","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2018.01.038_bib18","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.4049\/jimmunol.1003574","article-title":"Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis","volume":"186","author":"Sayed","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4049\/jimmunol.1003603","article-title":"Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression","volume":"187","author":"Li","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/labinvest.2011.3","article-title":"Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh\/W-sh mice","volume":"91","author":"Piconese","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaci.2018.01.038_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib22","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1091\/mbc.8.12.2631","article-title":"Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation","volume":"8","author":"Raposo","year":"1997","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaci.2018.01.038_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0091-6749(00)90188-X","article-title":"In\u00a0vitro and in\u00a0vivo immunostimulatory potential of bone marrow-derived mast cells on B- and T-lymphocyte activation","volume":"105","author":"Tkaczyk","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib24","doi-asserted-by":"crossref","first-page":"22325","DOI":"10.1038\/srep22325","article-title":"NAD(+) regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4(+) CD25(+) Foxp3(+) T cells independent","volume":"6","author":"Elkhal","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2018.01.038_bib25","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/ncomms6101","article-title":"NAD(+) protects against EAE by regulating CD4(+) T-cell differentiation","volume":"5","author":"Tullius","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2018.01.038_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/CIRCULATIONAHA.114.014917","article-title":"CD11c+ dendritic cells accelerate the rejection of older cardiac transplants via interleukin-17A","volume":"132","author":"Oberhuber","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2018.01.038_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature05746","article-title":"Chitin induces accumulation in tissue of innate immune cells associated with allergy","volume":"447","author":"Reese","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2018.01.038_bib29","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2018.01.038_bib30","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2018.01.038_bib31","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2018.01.038_bib32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature07240","article-title":"ATP drives lamina propria T(H)17 cell differentiation","volume":"455","author":"Atarashi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib33","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.4049\/jimmunol.164.7.3476","article-title":"Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression","volume":"164","author":"Nomura","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib34","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.4049\/jimmunol.181.7.5120","article-title":"Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists","volume":"181","author":"Roses","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nm.1906","article-title":"Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner","volume":"15","author":"Van Gool","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2018.01.038_bib36","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1096\/fj.06-5860com","article-title":"Skin mast cells control T cell-dependent host defense in Leishmania major infections","volume":"20","author":"Maurer","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2018.01.038_bib37","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1002\/eji.200535271","article-title":"Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis","volume":"35","author":"Gregory","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib38","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/hmg\/9.14.2167","article-title":"Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart","volume":"9","author":"Lam","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaci.2018.01.038_bib39","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1074\/jbc.M412845200","article-title":"Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum","volume":"280","author":"Kaliman","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2018.01.038_bib40","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1016\/j.febslet.2014.10.012","article-title":"FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin beta5 subunit and ROCK1","volume":"588","author":"Hu","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2018.01.038_bib41","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4049\/jimmunol.1302831","article-title":"The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation","volume":"192","author":"Knowlden","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib42","doi-asserted-by":"crossref","first-page":"e101655","DOI":"10.1371\/journal.pone.0101655","article-title":"Regulation of T cell motility in\u00a0vitro and in\u00a0vivo by LPA and LPA2","volume":"9","author":"Knowlden","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.038_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00428-007-0425-4","article-title":"Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)\/lysophospholipase D (lysoPLD)","volume":"451","author":"Mori","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jaci.2018.01.038_bib44","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1164\/rccm.201306-1014OC","article-title":"Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation","volume":"188","author":"Park","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2018.01.038_bib45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/jpet.105.098848","article-title":"Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes","volume":"318","author":"Kotarsky","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jaci.2018.01.038_bib46","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.4049\/jimmunol.164.10.4996","article-title":"Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes","volume":"164","author":"Goetzl","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1158\/2326-6066.CIR-13-0043-T","article-title":"Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression","volume":"1","author":"Oda","year":"2013","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.jaci.2018.01.038_bib48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1074-7613(00)80590-7","article-title":"Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation","volume":"9","author":"Snapper","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2018.01.038_bib49","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.4049\/jimmunol.171.10.5077","article-title":"CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity","volume":"171","author":"Lemos","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 mutations and human dendritic-cell immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2018.01.038_bib51","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature06175","article-title":"Taking dendritic cells into medicine","volume":"449","author":"Steinman","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.038_bib52","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nri3095","article-title":"TLR-dependent T cell activation in autoimmunity","volume":"11","author":"Mills","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib53","doi-asserted-by":"crossref","first-page":"ra12","DOI":"10.1126\/scisignal.2001270","article-title":"ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors","volume":"4","author":"Schenk","year":"2011","journal-title":"Sci Signal"},{"key":"10.1016\/j.jaci.2018.01.038_bib54","doi-asserted-by":"crossref","first-page":"18881","DOI":"10.1074\/jbc.M111773200","article-title":"Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels","volume":"277","author":"Anderson","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2018.01.038_bib55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrm.2016.93","article-title":"Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds","volume":"17","author":"Bonkowski","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2018.01.038_bib56","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2018.01.038_bib57","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.4049\/jimmunol.161.10.5600","article-title":"Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells","volume":"161","author":"Andersson","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.038_bib58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (*)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu Rev Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918302811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918302811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:15:07Z","timestamp":1758791707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918302811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0091674918302811"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.01.038","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.01.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}