{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:51:30Z","timestamp":1786499490260,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jaci.2018.01.042","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T03:08:38Z","timestamp":1523416118000},"page":"2121-2131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Nanoemulsion adjuvant\u2013driven redirection of TH2 immunity inhibits allergic reactions in murine models of peanut allergy"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-0586","authenticated-orcid":false,"given":"Jessica J.","family":"O'Konek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Landers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna W.","family":"Janczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi R.","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Mondrusov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James R.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.01.042_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","article-title":"Food allergy: epidemiology, pathogenesis, diagnosis, and treatment","volume":"133","author":"Sicherer","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1001\/jamapediatrics.2013.2376","article-title":"The economic impact of childhood food allergy in the United States","volume":"167","author":"Gupta","year":"2013","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaci.2018.01.042_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2015.03.048","article-title":"The allergy epidemics: 1870-2010","volume":"136","author":"Platts-Mills","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ni.1892","article-title":"The many paths to asthma: phenotype shaped by innate and adaptive immunity","volume":"11","author":"Kim","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2013.12.1088","article-title":"Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens","volume":"133","author":"Akdis","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib7","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1365-2222.2011.03804.x","article-title":"Mechanisms of immunotherapy to aeroallergens","volume":"41","author":"Shamji","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.01.042_bib8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0091-6749(92)90080-L","article-title":"Treatment of peanut allergy with rush immunotherapy","volume":"90","author":"Oppenheimer","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0091-6749(97)80006-1","article-title":"Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract","volume":"99","author":"Nelson","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000321822","article-title":"Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts","volume":"154","author":"Mondoulet","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jaci.2013.12.1040","article-title":"State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous","volume":"133","author":"Jones","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2011.10.023","article-title":"The safety and efficacy of sublingual and oral immunotherapy for milk allergy","volume":"129","author":"Keet","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJMoa1200435","article-title":"Oral immunotherapy for treatment of egg allergy in children","volume":"367","author":"Burks","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jaci.2014.12.1908","article-title":"The future of biologics: applications for food allergy","volume":"135","author":"Bauer","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.med.60.041807.123524","article-title":"Immunomodulation of allergic disease","volume":"60","author":"Broide","year":"2009","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib16","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jaci.2007.11.040","article-title":"Immunomodulators for allergic respiratory disorders","volume":"121","author":"Casale","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jaci.2010.06.029","article-title":"Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis","volume":"126","author":"Schimke","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nature06096","article-title":"Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome","volume":"448","author":"Minegishi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.01.042_bib19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jaci.2008.04.037","article-title":"Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome","volume":"122","author":"Renner","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jaci.2009.05.004","article-title":"Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome","volume":"124","author":"Al Khatib","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jaci.2016.04.023","article-title":"Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation","volume":"138","author":"Keles","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1615\/CritRevImmunol.v30.i2.60","article-title":"Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant","volume":"30","author":"Bielinska","year":"2010","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib24","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.4049\/jimmunol.1301424","article-title":"Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant","volume":"192","author":"Bielinska","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib25","doi-asserted-by":"crossref","first-page":"e21823","DOI":"10.1371\/journal.pone.0021823","article-title":"A novel inactivated intranasal respiratory syncytial virus vaccine promotes viral clearance without Th2 associated vaccine-enhanced disease","volume":"6","author":"Lindell","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.042_bib26","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/eji.201142346","article-title":"Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking","volume":"42","author":"Makidon","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib27","doi-asserted-by":"crossref","first-page":"e2954","DOI":"10.1371\/journal.pone.0002954","article-title":"Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine","volume":"3","author":"Makidon","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.042_bib28","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1016\/S0264-410X(03)00381-5","article-title":"Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A\u00a0virus and nanoemulsion","volume":"21","author":"Myc","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.01.042_bib29","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1128\/iai.64.11.4733-4738.1996","article-title":"Balance of inflammatory cytokines related to severity and mortality of murine sepsis","volume":"64","author":"Walley","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2018.01.042_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1067\/mai.2000.107395","article-title":"A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses","volume":"106","author":"Li","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1574-6941.2011.01207.x","article-title":"Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response","volume":"79","author":"Rodriguez","year":"2012","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.jaci.2018.01.042_bib32","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.4049\/jimmunol.163.12.6448","article-title":"Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling","volume":"163","author":"Brewer","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1518s79","article-title":"Animal models of airway sensitization","author":"Pichavant","year":"2007","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib34","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.ajpath.2011.12.036","article-title":"Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice","volume":"180","author":"Ahrens","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2018.01.042_bib35","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.4049\/jimmunol.156.8.2730","article-title":"Requirements of a costimulus for IL-4-induced IgE class switching in murine B cells activated via antigen receptors: effectiveness of 8-mercaptoguanosine","volume":"156","author":"Hikida","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/faat.1996.0171","article-title":"Specific antibody responses to subtilisin Carlsberg (Alcalase) in mice: development of an intranasal exposure model","volume":"34","author":"Robinson","year":"1996","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.jaci.2018.01.042_bib37","doi-asserted-by":"crossref","first-page":"e28917","DOI":"10.1371\/journal.pone.0028917","article-title":"Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses","volume":"6","author":"Smit","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.042_bib38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/mi.2012.55","article-title":"Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity","volume":"6","author":"Berin","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib39","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jaci.2013.06.008","article-title":"Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice","volume":"132","author":"Reber","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib40","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1016\/j.vaccine.2009.07.081","article-title":"Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion","volume":"27","author":"Baldwin","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.01.042_bib41","doi-asserted-by":"crossref","first-page":"e0146372","DOI":"10.1371\/journal.pone.0146372","article-title":"The TLR4 agonist vaccine adjuvant, GLA-SE, requires canonical and atypical mechanisms of action for TH1 induction","volume":"11","author":"Cauwelaert","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.042_bib42","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.it.2010.08.005","article-title":"Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide","volume":"31","author":"McAleer","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nri2510","article-title":"Towards an understanding of the adjuvant action of aluminium","volume":"9","author":"Marrack","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib44","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.vaccine.2004.01.061","article-title":"Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type","volume":"22","author":"Rimaniol","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.01.042_bib45","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1016\/j.vaccine.2016.06.043","article-title":"Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant","volume":"34","author":"Bielinska","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.01.042_bib46","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jaci.2016.01.047","article-title":"Investigation of peanut oral immunotherapy with CpG\/peanut nanoparticles in a murine model of peanut allergy","volume":"138","author":"Srivastava","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib47","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib48","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1084\/jem.20061401","article-title":"Interleukin-17 is a negative regulator of established allergic asthma","volume":"203","author":"Schnyder-Candrian","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib49","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.1102216","article-title":"IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner","volume":"188","author":"Newcomb","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib50","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.coi.2013.08.002","article-title":"Th17-mediated inflammation in asthma","volume":"25","author":"Newcomb","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajpath.2011.03.003","article-title":"IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease","volume":"179","author":"Mukherjee","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2018.01.042_bib52","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1038\/emi.2013.58","article-title":"IL-17 cytokines in immunity and inflammation","volume":"2","author":"Jin","year":"2013","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.jaci.2018.01.042_bib53","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/mi.2015.74","article-title":"Foxp3 T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation","volume":"9","author":"Yang","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib54","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/cea.12341","article-title":"IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses","volume":"44","author":"Lajoie","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.01.042_bib55","doi-asserted-by":"crossref","first-page":"e21799","DOI":"10.1371\/journal.pone.0021799","article-title":"IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease","volume":"6","author":"Taube","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.01.042_bib56","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.20051506","article-title":"CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function","volume":"202","author":"Lewkowich","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2018.01.042_bib57","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/gene.2014.45","article-title":"Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-beta","volume":"15","author":"Palomares","year":"2014","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2018.01.042_bib58","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood-2012-06-432153","article-title":"Control of regulatory T cells is necessary for vaccine-like effects of antiviral immunotherapy by monoclonal antibodies","volume":"121","author":"Nasser","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2018.01.042_bib59","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3389\/fimmu.2015.00510","article-title":"Regulatory T cells modulate DNA vaccine immunogenicity at early time via functional CD4(+) T cells and antigen duration","volume":"6","author":"Qin","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib60","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.4049\/jimmunol.1600066","article-title":"IL-10 enhances IgE-mediated mast cell responses and is essential for the development of experimental food allergy in IL-10-deficient mice","volume":"196","author":"Polukort","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib61","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/cea.12653","article-title":"Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy","volume":"46","author":"Schulten","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.01.042_bib62","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jaci.2014.05.033","article-title":"Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy","volume":"134","author":"Schulten","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib63","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/cea.12692","article-title":"Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity","volume":"46","author":"Hinz","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.01.042_bib64","doi-asserted-by":"crossref","first-page":"E1286","DOI":"10.1073\/pnas.1520180113","article-title":"Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets","volume":"113","author":"Ryan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2018.01.042_bib65","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.it.2014.11.002","article-title":"IgE responses in mouse and man and the persistence of IgE memory","volume":"36","author":"Gould","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00430-009-0137-2","article-title":"Induction of immune response to the 17 kDa OMPA Burkholderia cenocepacia polypeptide and protection against pulmonary infection in mice after nasal vaccination with an OMP nanoemulsion-based vaccine","volume":"199","author":"Makidon","year":"2010","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib67","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.vaccine.2011.10.094","article-title":"Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens","volume":"30","author":"Stanberry","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.01.042_bib68","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/cmi.2016.14","article-title":"Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut","volume":"14","author":"Dioszeghy","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib69","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaci.2016.05.027","article-title":"Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective","volume":"139","author":"Vickery","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib70","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2013.11.007","article-title":"Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy","volume":"133","author":"Vickery","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.01.042_bib71","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jaci.2014.11.005","article-title":"A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy","volume":"135","author":"Narisety","year":"2015","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:08:58Z","timestamp":1758791338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918303002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0091674918303002"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.01.042","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoemulsion adjuvant\u2013driven redirection of TH2 immunity inhibits allergic reactions in murine models of peanut allergy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}