{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:58Z","timestamp":1792000078904,"version":"4.4.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jaci.2018.02.017","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T19:10:58Z","timestamp":1520017858000},"page":"2208-2219.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":279,"title":["Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood"],"prefix":"10.1016","volume":"141","author":[{"given":"Elena","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"P\u00e9rez-Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Arriba-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Contreras-Sanfeliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Criado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Pelak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Serra-Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Remesal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Torres Canizales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"L\u00f3pez-Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kalina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"van Zelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"van der Burg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques J.M.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.02.017_bib1","first-page":"162","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"5","author":"Al-Herz","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev.me.38.020187.001545","article-title":"IgG subclass deficiencies","volume":"38","author":"Ochs","year":"1987","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaci.2018.02.017_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-1-4160-3611-1.50006-4","article-title":"General aspects of vaccination","volume":"2","author":"Siegrist","year":"2008","journal-title":"Vaccine Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/10428194.2012.706285","article-title":"Immunoglobulin G subclass deficiency and infection risk in 150 patients with chronic lymphocytic leukemia","volume":"54","author":"Freeman","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jaci.2018.02.017_bib5","first-page":"115","article-title":"Serum levels and in\u00a0vitro production of IgA subclasses in patients with primary IgA nephropathy","volume":"74","author":"van den Wall Bake","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib6","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1097\/MD.0000000000000387","article-title":"Serum IgG subclasses in autoimmune diseases","volume":"94","author":"Zhang","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2018.02.017_bib7","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1373\/clinchem.2003.022350","article-title":"IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents","volume":"49","author":"Schauer","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.jaci.2018.02.017_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0009-8981(02)00418-7","article-title":"Establishment of age-dependent reference values for IgA subclasses","volume":"328","author":"Schauer","year":"2003","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jaci.2018.02.017_bib9","first-page":"501","article-title":"Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age","volume":"21","author":"van der Giessen","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/adc.60.3.204","article-title":"Reference children for IgG subclasses in preschool","volume":"60","author":"Bird","year":"1985","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2018.02.017_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1365-3083.2000.00702.x","article-title":"Serum immunoglobulinD in infants and children","volume":"51","author":"Haraldsson","year":"2000","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/clinchem\/45.2.309","article-title":"Reference values of serum IgA subclasses in caucasian adults by immunonephelometry","volume":"45","author":"Berth","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jaci.2018.02.017_bib13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.37.5.715","article-title":"Serum levels of immune globulins in health and disease: a survey","volume":"37","author":"Stiehm","year":"1966","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2018.02.017_bib14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1542\/peds.41.3.600","article-title":"Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy","volume":"41","author":"Buckley","year":"1968","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2018.02.017_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0022-3476(68)80324-5","article-title":"The development of immunoglobulin levels in man","volume":"72","author":"Allansmith","year":"1968","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2018.02.017_bib16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01958271","article-title":"Serum IgG subclass concentrations in healthy subjects at different age: age normal percentile charts","volume":"149","author":"Plebani","year":"1989","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jaci.2018.02.017_bib17","first-page":"561","article-title":"Nephelometric measurements of human IgG subclasses and their reference ranges","volume":"52","author":"Vlug","year":"1994","journal-title":"Ann Biol Clin (Paris)"},{"key":"10.1016\/j.jaci.2018.02.017_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.23.021704.115723","article-title":"Maintenance of serum antibody levels","volume":"23","author":"Manz","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0161-5890(83)90038-X","article-title":"Serum levels of IgA1 and IgA2 in children and in patients with IgA deficiency","volume":"20","author":"Conley","year":"1983","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1537-2995.1986.26186124037.x","article-title":"Selective absence of immunoglobulin A1 or A2 among blood donors and hospital patients","volume":"26","author":"Ozawa","year":"1986","journal-title":"Transfusion"},{"key":"10.1016\/j.jaci.2018.02.017_bib21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaci.2013.08.037","article-title":"New childhood and adult reference intervals for total IgE","volume":"133","author":"Martins","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0022-3476(97)70200-2","article-title":"Immunophenotyping of blood lymphocytes in childhood: Reference values for lymphocyte subpopulations","volume":"130","author":"Comans-Bitter","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2018.02.017_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/cyto.b.20536","article-title":"B cell subsets in healthy children: Reference values for evaluation of B cell maturation process in peripheral blood","volume":"78","author":"Piatosa","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaci.2018.02.017_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clim.2009.05.020","article-title":"Refined characterization and reference values of the pediatric T- and B-cell compartments","volume":"133","author":"van Gent","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib25","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.jaci.2016.10.023","article-title":"Effects of nongenetic factors on immune cell dynamics in early childhood: the Generation R Study","volume":"139","author":"van den Heuvel","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2249.2010.04206.x","article-title":"Reference values for B cell subpopulations from infancy to adulthood","volume":"162","author":"Morbach","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib27","first-page":"47","article-title":"Human peripheral blood B-Cell compartments: a crossroad in B-cell traffic","volume":"78","author":"Perez-Andres","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaci.2018.02.017_bib28","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3324\/haematol.2009.018689","article-title":"Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells","volume":"95","author":"Caraux","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jaci.2018.02.017_bib29","doi-asserted-by":"crossref","first-page":"e0126019","DOI":"10.1371\/journal.pone.0126019","article-title":"Decreased memory B cells and increased CD8 memory T cells in blood of breastfed children: the generation R study","volume":"10","author":"Jansen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.02.017_bib30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ni.3371","article-title":"The cellular composition of the human immune system is shaped by age and cohabitation","volume":"17","author":"Carr","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib31","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/leu.2017.29","article-title":"Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma","volume":"31","author":"Flores-Montero","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.jaci.2018.02.017_bib32","article-title":"Selection and validation of antibody clones against IgG and IgA subclasses in switched memory B-cells and plasma cells","author":"Blanco","year":"2017","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jaci.2018.02.017_bib33","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/leu.2012.122","article-title":"EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols","volume":"26","author":"Kalina","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.jaci.2018.02.017_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.imlet.2014.11.003","article-title":"Determination of lymphocyte subset reference ranges in peripheral blood of healthy adults by a dual-platform flow cytometry method","volume":"163","author":"Rudolf-Oliveira","year":"2015","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2018.02.017_bib35","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2018.02.017_bib36","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1182\/blood-2004-11-4284","article-title":"Identification and characterization of circulating human transitional B cells","volume":"105","author":"Sims","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2018.02.017_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/40540","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"Manz","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2018.02.017_bib38","doi-asserted-by":"crossref","first-page":"e85227","DOI":"10.1371\/journal.pone.0085227","article-title":"Age related differences in dynamics of specific memory B cell populations after clinical pertussis infection","volume":"9","author":"van Twillert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2018.02.017_bib39","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12563","article-title":"IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis","volume":"70","author":"Wong","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.02.017_bib40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jaci.2014.03.036","article-title":"Human IgE+ B cells are derived from T cell-dependent and T cell-independent pathways","volume":"134","author":"Berkowska","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaci.2015.08.027","article-title":"Diverse activation and differentiation of multiple B-cell subsets in patients with atopic dermatitis but not in patients with psoriasis","volume":"137","author":"Czarnowicki","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/08880010903420687","article-title":"Striking decrease in the total precursor B-cell compartment during early childhood as evidenced by flow cytometry and gene expression changes","volume":"27","author":"Jensen","year":"2010","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.jaci.2018.02.017_bib43","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.4049\/jimmunol.180.4.2165","article-title":"The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response","volume":"180","author":"Blanchard Rohner","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri2508","article-title":"B-cell responses to vaccination at the extremes of age","volume":"9","author":"Siegrist","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"23","key":"10.1016\/j.jaci.2018.02.017_bib45","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V126.23.4180.4180","article-title":"Next Generation Flow (NGF): a hgh sensitive technique to detect circulating peripheral blood (PB) clonal plasma cells (cPC) in patients with newly diagnosed plasma cell neoplasms (PCN)","volume":"126","author":"Sanoja-Flores","year":"2015","journal-title":"Blood"},{"issue":"suppl","key":"10.1016\/j.jaci.2018.02.017_bib46","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/cei.12496","article-title":"The European Society for Immunodeficiencies (ESID) registry 2014","volume":"178","author":"Grimbacher","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib47","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jaci.2009.10.013","article-title":"Primary immunodeficiencies: 2009 update","volume":"124","author":"Notarangelo","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4049\/jimmunol.176.1.165","article-title":"Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival","volume":"176","author":"Pihlgren","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib49","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.121.6.969","article-title":"Antibody synthesis at the cellular level. Antibody-induced suppression of 19S and 7S antibody response","volume":"121","author":"Moller","year":"1965","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2018.02.017_bib50","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4049\/jimmunol.102.4.1008","article-title":"The immunosuppressive effect of passively administered antibody IgG fragments","volume":"102","author":"Cerottini","year":"1969","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.virusres.2004.02.025","article-title":"Immunogenicity and protective efficacy of influenza vaccination","volume":"103","author":"Hannoun","year":"2004","journal-title":"Virus Res"},{"key":"10.1016\/j.jaci.2018.02.017_bib52","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.vaccine.2005.08.105","article-title":"Antibody response to influenza vaccination in the elderly: a quantitative review","volume":"24","author":"Goodwin","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jaci.2018.02.017_bib53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/B:EJEP.0000024752.48929.bd","article-title":"The 23-valent pneumococcal polysaccharide vaccine. Part II. A\u00a0cost-effectiveness analysis for invasive disease in the elderly in England and Wales","volume":"19","author":"Melegaro","year":"2004","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jaci.2018.02.017_bib54","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/529197","article-title":"Biology of immune responses to vaccines in elderly persons","volume":"46","author":"Weinberger","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaci.2018.02.017_bib55","doi-asserted-by":"crossref","first-page":"F186","DOI":"10.1136\/fn.83.3.F186","article-title":"Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months","volume":"83","author":"Gr\u00f6nlund","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jaci.2018.02.017_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00235","article-title":"A temporal model of human IgE and IgG antibody function","volume":"4","author":"Collins","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/icb.2014.44","article-title":"Human immunoglobulin classes and subclasses show variability in VDJ gene mutation levels","volume":"92","author":"Jackson","year":"2014","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jaci.2018.02.017_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front Immunol"},{"issue":"suppl","key":"10.1016\/j.jaci.2018.02.017_bib59","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","article-title":"Structure and Function of Immunoglobulins","volume":"125","author":"Schroeder","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib60","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/mi.2011.39","article-title":"Structure and function relationships in IgA","volume":"4","author":"Woof","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib61","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0378-3782(78)90044-0","article-title":"Germinal centers in the spleens of neonates and stillbirths","volume":"1","author":"Barzanji","year":"1978","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jaci.2018.02.017_bib62","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.33.5.454","article-title":"Human lymph node morphology as a function of age and site","volume":"33","author":"Luscieti","year":"1980","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jaci.2018.02.017_bib63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-3083.1989.tb01104.x","article-title":"Immunohistological analysis of human fetal lymph nodes","volume":"29","author":"Westerga","year":"1989","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib64","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.4049\/jimmunol.177.6.3728","article-title":"A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation","volume":"177","author":"Fecteau","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib65","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1128\/iai.59.5.1839-1845.1991","article-title":"Pneumococcal polysaccharides complexed with C3d bind to human B lymphocytes via complement receptor type 2","volume":"59","author":"Griffioen","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2018.02.017_bib66","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2011.09.027","article-title":"Genetic CD21 deficiency is associated with hypogammaglobulinemia","volume":"129","author":"Thiel","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib67","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1203\/00006450-199804000-00010","article-title":"Characterization of early activation events in cord blood B cells after stimulation with T cell-independent activators","volume":"43","author":"Halista","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jaci.2018.02.017_bib68","first-page":"571","article-title":"[Development of the serum levels of complement during the first year of life]","volume":"13","author":"Pedraz","year":"1980","journal-title":"An Esp Pediatr"},{"key":"10.1016\/j.jaci.2018.02.017_bib69","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1542\/peds.64.5.781","article-title":"Complement in the newborn infant","volume":"64","author":"Johnston","year":"1979","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2018.02.017_bib70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.coi.2017.03.004","article-title":"An antigen to remember: regulation of B cell memory in health and disease","volume":"45","author":"Pupovac","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2018.02.017_bib71","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/imr.12380","article-title":"Age-associated B cells: key mediators of both protective and autoreactive humoral responses","volume":"269","author":"Naradikian","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2018.02.017_bib72","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/sj.leu.2402584","article-title":"Incidence of phenotypic aberrations in a series of 467 patients with B chronic lymphoproliferative disorders: basis for the design of specific four-color stainings to be used for minimal residual disease investigation","volume":"16","author":"S\u00e1nchez","year":"2002","journal-title":"Leukemia"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918303051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:12:18Z","timestamp":1758791538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918303051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0091674918303051"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.02.017","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}