{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:21:43Z","timestamp":1789597303317,"version":"build-2803163510"},"reference-count":14,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jaci.2018.05.037","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T13:46:37Z","timestamp":1529588797000},"page":"1360-1363.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype"],"prefix":"10.1016","volume":"142","author":[{"given":"Ksenija","family":"Bernau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Leet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Esnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar N.","family":"Jarjour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Sandbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.05.037_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2017.02.045","article-title":"Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team. Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma","volume":"141","author":"Rossios","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jaci.2013.10.011","article-title":"Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis","volume":"133","author":"Moore","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12931-017-0669-8","article-title":"RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism","volume":"18","author":"Esnault","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2018.05.037_bib6","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jaci.2017.06.033","article-title":"Sputum autoantibodies in patients with severe eosinophilic asthma","volume":"141","author":"Mukherjee","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/cea.12876","article-title":"IL-3 up-regulates and activates human eosinophil CD32 and alphaMbeta2 integrin causing degranulation","volume":"47","author":"Esnault","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.05.037_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.05.037_bib9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pupt.2014.03.001","article-title":"Regulation of pulmonary inflammation by mesenchymal cells","volume":"29","author":"Alkhouri","year":"2014","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jaci.2018.05.037_bibE1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/cea.12876","article-title":"IL-3 up-regulates and activates human eosinophil CD32 and alphaMbeta2 integrin causing degranulation","volume":"47","author":"Esnault","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.05.037_bibE2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1164\/rccm.200308-1156OC","article-title":"Increased thrombin activity after allergen challenge: a potential link to airway remodeling?","volume":"169","author":"Terada","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2018.05.037_bibE3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12931-017-0669-8","article-title":"RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism","volume":"18","author":"Esnault","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2018.05.037_bibE4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1164\/ajrccm.156.5.9703054","article-title":"The effect of segmental bronchoprovocation with allergen on airway lymphocyte function","volume":"156","author":"Kelly","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2018.05.037_bibE5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2016.6769","article-title":"Dual inhibition of PI3K\/Akt and mTOR by the dietary antioxidant, delphinidin, ameliorates psoriatic features in\u00a0vitro and in an imiquimod-induced psoriasis-like disease in mice","volume":"26","author":"Chamcheu","year":"2017","journal-title":"Antioxid Redox Signal"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918308996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918308996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:14:03Z","timestamp":1758791643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918308996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0091674918308996"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.05.037","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}