{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:49:39Z","timestamp":1792550979345,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PREDICTA"},{"DOI":"10.13039\/100011102","name":"European Commission's Seventh Framework programme","doi-asserted-by":"publisher","award":["260895"],"award-info":[{"award-number":["260895"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"European Commission's Seventh Framework Programme","doi-asserted-by":"publisher","award":["261357"],"award-info":[{"award-number":["261357"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010385","name":"Christine K\u00fchne-Center for Allergy Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jaci.2018.11.016","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T13:24:05Z","timestamp":1543325045000},"page":"1892-1903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"title":["Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells"],"prefix":"10.1016","volume":"143","author":[{"given":"Ming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Eljaszewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Wawrzyniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Altunbulakli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Dreher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari C.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.11.016_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nri1958","article-title":"The increase in the prevalence of asthma and allergy: food for thought","volume":"6","author":"Devereux","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/thx.2006.066407","article-title":"50 years of asthma: UK trends from 1955 to 2004","volume":"62","author":"Anderson","year":"2007","journal-title":"Thorax"},{"issue":"suppl\u00a095","key":"10.1016\/j.jaci.2018.11.016_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1398-9995.2011.02619.x","article-title":"The increase in allergy and extended challenges","volume":"66","author":"Linneberg","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.016_bib4","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1111\/all.13492","article-title":"Hygienic behavior and allergic sensitization in German adolescents","volume":"73","author":"Bowatte","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.016_bib5","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1016\/j.lpm.2013.06.010","article-title":"Environment and asthma in adults","volume":"42","author":"Le Moual","year":"2013","journal-title":"Presse Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib6","first-page":"475","article-title":"Environmental factors and allergic diseases","volume":"19","author":"Jenerowicz","year":"2012","journal-title":"Ann Agric Environ Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/ACI.0000000000000349","article-title":"Update on asthma and cleaning agents","volume":"17","author":"Folletti","year":"2017","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib8","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1183\/09031936.00197611","article-title":"Domestic use of cleaning sprays and asthma activity in females","volume":"40","author":"Le Moual","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2018.11.016_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1164\/rccm.200612-1793OC","article-title":"The use of household cleaning sprays and adult asthma: an international longitudinal study","volume":"176","author":"Zock","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/oem.2008.045245","article-title":"A cross-sectional study among detergent workers exposed to liquid detergent enzymes","volume":"66","author":"van Rooy","year":"2009","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib11","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/oem.2004.017640","article-title":"Asthma, chronic bronchitis, and exposure to irritant agents in occupational domestic cleaning: a nested case-control study","volume":"62","author":"Medina-Ramon","year":"2005","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/occmed\/kqr107","article-title":"Occupational asthma and rhinitis due to detergent enzymes in healthcare","volume":"61","author":"Adisesh","year":"2011","journal-title":"Occup Med (Lond)"},{"key":"10.1016\/j.jaci.2018.11.016_bib13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ajim.22036","article-title":"Occupational rhinitis and asthma due to EDTA-containing detergents or disinfectants","volume":"55","author":"Laborde-Casterot","year":"2012","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(00)03264-5","article-title":"An outbreak of asthma in a modern detergent factory","volume":"356","author":"Cullinan","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2018.11.016_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2014.05.049","article-title":"Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation","volume":"134","author":"Georas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib16","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.jaci.2017.04.005","article-title":"Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients","volume":"139","author":"Loxham","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib17","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2737","article-title":"The airway epithelium in asthma","volume":"18","author":"Lambrecht","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib18","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jaci.2016.07.003","article-title":"Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes","volume":"138","author":"Xian","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2018.11.016_bib20","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1093\/nar\/gkt214","article-title":"The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2018.11.016_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2018.11.016_bib22","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2018.11.016_bib23","doi-asserted-by":"crossref","first-page":"21.9.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: a method for assaying chromatin accessibility genome-wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr Protoc Mol Biol"},{"key":"10.1016\/j.jaci.2018.11.016_bib24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.jaci.2018.11.016_bib25","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.12688\/f1000research.8839.2","article-title":"A cross-package Bioconductor workflow for analysing methylation array data","volume":"5","author":"Maksimovic","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.jaci.2018.11.016_bib26","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2018.11.016_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","article-title":"Lipopolysaccharide causes an increase in intestinal tight junction permeability in\u00a0vitro and in\u00a0vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14","volume":"182","author":"Guo","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2018.11.016_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4899-7678-9_1","article-title":"Epigenetic mechanisms as an interface between the environment and genome","volume":"903","author":"Herceg","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaci.2018.11.016_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaci.2015.01.025","article-title":"DNA methylation and childhood asthma in the inner city","volume":"136","author":"Yang","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib30","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jaci.2017.12.1006","article-title":"Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility","volume":"142","author":"Stadhouders","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jaci.2016.03.050","article-title":"Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients","volume":"139","author":"Wawrzyniak","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaci.2017.02.038","article-title":"Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients","volume":"141","author":"Sugita","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbamem.2004.04.011","article-title":"Membrane proteins, lipids and detergents: not just a soap opera","volume":"1666","author":"Seddon","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2018.11.016_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/molehr\/gau087","article-title":"Endometrial apical glycoproteomic analysis reveals roles for cadherin 6, desmoglein-2 and plexin b2 in epithelial integrity","volume":"21","author":"Singh","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.jaci.2018.11.016_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/bph.12452","article-title":"PDGF and TGF-beta promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice","volume":"171","author":"Islam","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2018.11.016_bib36","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.chest.2016.10.042","article-title":"Epithelial-derived cytokines in asthma","volume":"151","author":"Mitchell","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2018.11.016_bib37","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-4529","article-title":"Pediatric exposures to laundry and dishwasher detergents in the United States: 2013-2014","volume":"137","author":"Davis","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2018.11.016_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/injuryprev-2016-042263","article-title":"Surveillance of paediatric exposures to liquid laundry detergent pods in Italy","volume":"24","author":"Settimi","year":"2018","journal-title":"Inj Prev"},{"key":"10.1016\/j.jaci.2018.11.016_bib39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/ACI.0b013e32835143b8","article-title":"Irritant-induced asthma","volume":"12","author":"Labrecque","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib40","first-page":"542","article-title":"Cleaning agents and asthma","volume":"20","author":"Quirce","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ajim.4700210414","article-title":"Allergic asthma to Bacillus subtilis enzyme: a model for the effects of inhalable proteins","volume":"21","author":"Pepys","year":"1992","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.jaci.2018.11.016_bib42","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/09603123.2015.1135314","article-title":"Symptom-trigger factors other than allergens in asthma and allergy","volume":"26","author":"Claeson","year":"2016","journal-title":"Int J Environ Health Res"},{"key":"10.1016\/j.jaci.2018.11.016_bib43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2310\/6620.2007.06052","article-title":"Allergens retained in clothing","volume":"18","author":"Nedorost","year":"2007","journal-title":"Dermatitis"},{"key":"10.1016\/j.jaci.2018.11.016_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.5271\/sjweh.590","article-title":"Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners","volume":"27","author":"Zock","year":"2001","journal-title":"Scand J Work Environ Health"},{"key":"10.1016\/j.jaci.2018.11.016_bib45","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.biochi.2012.07.017","article-title":"Epigenetics in asthma and COPD","volume":"94","author":"Kabesch","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.jaci.2018.11.016_bib46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.11.021","article-title":"Respiratory health effects of air pollution: update on biomass smoke and traffic pollution","volume":"129","author":"Laumbach","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jaci.2017.05.011","article-title":"The environment, epigenome, and asthma","volume":"140","author":"Yang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jaci.2016.03.046","article-title":"Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation","volume":"139","author":"Clifford","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.016_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cell.2015.08.046","article-title":"Tracing dynamic changes of DNA methylation at single-cell resolution","volume":"163","author":"Stelzer","year":"2015","journal-title":"Cell"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918316658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918316658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:18:10Z","timestamp":1758791890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918316658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0091674918316658"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.11.016","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}