{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:39:36Z","timestamp":1791214776647,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"HAL Allergy B.V."},{"name":"HAL Allergy B.V."},{"name":"ALK-Abell\u00f3"},{"DOI":"10.13039\/100009946","name":"Allergopharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009946","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stallergenes Greer"},{"name":"HAL Allergy B.V."},{"name":"Bencard Allergie GmbH"},{"name":"Lofarma"},{"name":"Biomay"},{"name":"Nuvo"},{"name":"Circassia"},{"name":"Biotech Tools S.A."},{"name":"Laboratorios LETI"},{"name":"Anergis S.A."},{"name":"GlaxoSmithKline"},{"name":"HAL"},{"name":"ALK-Abell\u00f3"},{"name":"Stallergenes Greer"},{"name":"Biotech Tools"},{"name":"Novartis Pharma"},{"name":"Mylan"},{"name":"GlaxoSmithKline"},{"name":"Sanofi Aventis"},{"name":"AstraZeneca"},{"name":"ALK-Abell\u00f3"},{"name":"Novartis"},{"name":"Allergopharma"},{"name":"Bionorica"},{"name":"GlaxoSmithKlinea"},{"name":"Lofarma"},{"name":"Biomay"},{"name":"HAL"},{"name":"LETI"},{"name":"Roxall"},{"name":"Bencard"},{"name":"HAL Allergy B.V., Leiden, The Netherlands"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jaci.2018.11.018","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T11:52:07Z","timestamp":1543578727000},"page":"970-977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma"],"prefix":"10.1016","volume":"143","author":[{"given":"Oliver","family":"Pfaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Panzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"D\u017eupinov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroesja J.","family":"van Nimwegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan D.","family":"Boot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk Jan E.","family":"Opstelten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter-Jan","family":"de Kam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl\u00a086","key":"10.1016\/j.jaci.2018.11.018_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"issue":"suppl\u00a085","key":"10.1016\/j.jaci.2018.11.018_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1398-9995.2007.01549.x","article-title":"A survey of the burden of allergic rhinitis in Europe","volume":"62","author":"Canonica","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1398-9995.2007.01586.x","article-title":"Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report","volume":"63","author":"Bacharier","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib4","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaci.2007.07.020","article-title":"Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study","volume":"120","author":"Burgess","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib5","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jaci.2015.07.038","article-title":"Allergy immunotherapy for allergic rhinitis effectively prevents asthma: results from a large retrospective cohort study","volume":"136","author":"Schmitt","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2010.06.034","article-title":"Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial","volume":"126","author":"Bousquet","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jaci.2015.04.047","article-title":"International consensus on allergy immunotherapy","volume":"136","author":"Jutel","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s40629-014-0032-2","volume":"23","author":"Pfaar","year":"2014","journal-title":"Allergo J Int"},{"issue":"suppl","key":"10.1016\/j.jaci.2018.11.018_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/all.13317","article-title":"EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis","volume":"73","author":"Roberts","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000071538","article-title":"Allergen biodistribution in humans","volume":"82","author":"Bagnasco","year":"2003","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jaci.2015.12.1300","article-title":"International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics","volume":"137","author":"Jutel","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1939-4551-7-6","article-title":"Sublingual immunotherapy: World Allergy Organization position paper 2013 update","volume":"7","author":"Canonica","year":"2014","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaci.2018.11.018_bib14","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/all.13201","article-title":"Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis","volume":"72","author":"Dhami","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib15","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/all.13208","article-title":"Allergen immunotherapy for allergic asthma: a systematic review and meta-analysis","volume":"72","author":"Dhami","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1398-9995.2011.02583.x","article-title":"Systematic reviews of sublingual immunotherapy (SLIT)","volume":"66","author":"Radulovic","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib17","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1001\/jama.2013.2049","article-title":"Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review","volume":"309","author":"Lin","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2018.11.018_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/all.12760","article-title":"A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study","volume":"71","author":"Pfaar","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib20","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/all.12383","article-title":"Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper","volume":"69","author":"Pfaar","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib21","series-title":"Allergenic pollen","first-page":"161","article-title":"Impact of pollen","author":"de Weger","year":"2013"},{"key":"10.1016\/j.jaci.2018.11.018_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2222.1991.tb00807.x","article-title":"Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis","volume":"21","author":"Juniper","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib23","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2018.11.018_bib24","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual Life Res"},{"issue":"suppl\u00a082","key":"10.1016\/j.jaci.2018.11.018_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1398-9995.2006.01219_1.x","article-title":"Standards for practical allergen-specific immunotherapy","volume":"61","author":"Alvarez-Cuesta","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1398-9995.2005.00949.x","article-title":"Specific immunotherapy with SQ standardized grass allergen tablets in asthmatics with rhinoconjunctivitis","volume":"61","author":"Dahl","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1398-9995.2010.02434.x","article-title":"Days with severe symptoms: an additional efficacy endpoint in immunotherapy trials","volume":"66","author":"Durham","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.2006.01312.x","article-title":"Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A\u00a0statement of a World Allergy Organization (WAO) taskforce","volume":"62","author":"Canonica","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib29","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jaci.2017.10.010","article-title":"Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers","volume":"140","author":"Shamji","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.11.018_bib30","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/all.13138","article-title":"Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper","volume":"72","author":"Shamji","year":"2017","journal-title":"Allergy"},{"issue":"suppl\u00a0104","key":"10.1016\/j.jaci.2018.11.018_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/all.13355","article-title":"Perspectives in allergen immunotherapy: 2017 and beyond","volume":"73","author":"Pfaar","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2018.11.018_bib32","series-title":"Allergen immunotherapy guidelines part 1: systematic reviews","year":"2017"},{"key":"10.1016\/j.jaci.2018.11.018_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.iac.2011.02.004","article-title":"Allergen-specific immunotherapy: which outcome measures are useful in monitoring clinical trials?","volume":"31","author":"Pfaar","year":"2011","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2018.11.018_bib34","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/all.13429","article-title":"Clinical trials in allergen immunotherapy: current concepts and future needs","volume":"73","author":"Pfaar","year":"2018","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918317202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674918317202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:19:01Z","timestamp":1758791941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674918317202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0091674918317202"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.11.018","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sublingual allergen immunotherapy with a liquid birch pollen product in patients with seasonal allergic rhinoconjunctivitis with or without asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}