{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:34:38Z","timestamp":1779244478795,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011878","name":"Flanders","doi-asserted-by":"publisher","award":["G0C8517N"],"award-info":[{"award-number":["G0C8517N"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Flanders","doi-asserted-by":"publisher","award":["G0C8517N"],"award-info":[{"award-number":["G0C8517N"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007343","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007343","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Octapharma"},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jaci.2018.12.1013","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T11:23:20Z","timestamp":1548242600000},"page":"1952-1956.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome"],"prefix":"10.1016","volume":"143","author":[{"given":"Giorgia","family":"Bucciol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Nicholas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Cant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. David M.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Espa\u00f1ol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ferrua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Galicchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Gennery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedim","family":"Hadzic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. Celine","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Kusminsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Mahlaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Moshous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Nademi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicte","family":"Neven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Oleastro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Quarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary A.","family":"Slatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Soncini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Stefanowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Tandoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko\u0142aj","family":"Teisseyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy R.","family":"Torgerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Veys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja G.","family":"Weinacht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Wolska-Ku\u015bnierz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"de la Morena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Meyts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2018.12.1013_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12016-013-8378-7","article-title":"The hyper IgM syndromes","volume":"46","author":"Qamar","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2018.12.1013_bib2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jaip.2016.09.013","article-title":"Clinical phenotypes of hyper-IgM syndromes","volume":"4","author":"de la Morena","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2018.12.1013_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(97)70123-9","article-title":"Clinical spectrum of X-linked hyper-IgM syndrome","volume":"131","author":"Levy","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaci.2018.12.1013_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.md.0000100046.06009.b0","article-title":"The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients","volume":"82","author":"Winkelstein","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaci.2018.12.1013_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s10875-016-0291-4","article-title":"Hyper IgM syndrome: a report from the USIDNET registry","volume":"36","author":"Leven","year":"2016","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2018.12.1013_bib6","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2016.07.039","article-title":"Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation","volume":"139","author":"de la Morena","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.12.1013_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jaci.2017.06.036","article-title":"Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper-IgM but can be prevented by early hematopoietic stem cell transplantation","volume":"141","author":"Azzu","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.12.1013_bib8","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/TP.0000000000001503","article-title":"Cryptosporidium spp. infection in solid organ transplantation: the nationwide \u201cTRANSCRYPTO\u201d study","volume":"101","author":"Lanternier","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.jaci.2018.12.1013_bib9","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jaci.2015.02.020","article-title":"Clinical features and hematopoietic stem cell transplantations for CD40 ligand deficiency in Japan","volume":"136","author":"Mitsui-Sekinaka","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2567.2006.02520.x","article-title":"Hyper-immunoglobulin M syndrome caused by a mutation in the promotor for CD40L","volume":"120","author":"Van Hoeyveld","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE2","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1016\/j.transproceed.2010.09.170","article-title":"Liver transplantation for severe hepatic graft-versus-host disease in two children after hematopoietic stem cell transplantation","volume":"42","author":"Teisseyre","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/TP.0000000000002114","article-title":"Successful sequential liver and haematopoietic stem cell transplantation in a child with CD40 ligand deficiency and Cryptosporidium-induced liver cirrhosis","volume":"102","author":"Quarello","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE4","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJM200002033420504","article-title":"Correction of the hyper-IgM syndrome after liver and bone marrow transplantation","volume":"342","author":"Had\u017ei\u0107","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1399-0004.1995.tb04053.x","article-title":"Identification of a CD40L gene mutation and genetic counselling in a family with immunodeficiency with hyperimmunoglobulinemia M","volume":"48","author":"Kraakman","year":"2008","journal-title":"Clin Genet"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0041-1345(96)00172-8","article-title":"Relapse of sclerosing cholangitis after liver transplant in patients with hyper-IgM syndrome","volume":"29","author":"Martinez Ibanez","year":"1997","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jaci.2018.12.1013_bibE7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jamcollsurg.2017.12.042","article-title":"One thousand pediatric liver transplants during thirty years: lessons learned","volume":"226","author":"Venick","year":"2018","journal-title":"J Am Coll Surg"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919300776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919300776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:18:37Z","timestamp":1758791917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674919300776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0091674919300776"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2018.12.1013","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2018.12.1013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}