{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:57:50Z","timestamp":1790243870669,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009882","name":"Regione Lombardia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jaci.2019.03.012","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T13:29:19Z","timestamp":1553693359000},"page":"825-838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Lentiviral gene therapy corrects platelet phenotype and function in patients with Wiskott-Aldrich syndrome"],"prefix":"10.1016","volume":"144","author":[{"given":"Lucia","family":"Sereni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmina","family":"Castiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Di Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Della Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Brombin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ferrua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Cicalese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Migliavacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ester","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pignata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roula","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Dora","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nufar","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorella","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Giannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Bosticardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"van Rossem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Aiuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2019.03.012_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ACI.0b013e32834c230c","article-title":"Gene therapy for the Wiskott-Aldrich syndrome","volume":"11","author":"Galy","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1182\/blood-2003-05-1480","article-title":"Clinical course of patients with WASP gene mutations","volume":"103","author":"Imai","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(94)90528-2","article-title":"Isolation of a novel gene mutated in Wiskott-Aldrich syndrome","volume":"78","author":"Derry","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2019.03.012_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0092-8674(00)81050-8","article-title":"Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization","volume":"84","author":"Symons","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2019.03.012_bib5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ng0495-414","article-title":"X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene","volume":"9","author":"Villa","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2019.03.012_bib6","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1182\/blood.V99.6.2268","article-title":"Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia","volume":"99","author":"Notarangelo","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib7","first-page":"212","article-title":"Familiar Angeborener Morbus Werlhofii?","volume":"68","author":"Wiskott","year":"1937","journal-title":"Monatschr Kinderheilkd"},{"key":"10.1016\/j.jaci.2019.03.012_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.13.2.133","article-title":"Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea","volume":"13","author":"Aldrich","year":"1954","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2019.03.012_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2006.02.005","article-title":"The Wiskott-Aldrich syndrome","volume":"117","author":"Ochs","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib10","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1182\/blood.V99.8.2694","article-title":"Autoimmunity in human primary immunodeficiency diseases","volume":"99","author":"Arkwright","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib11","first-page":"379","article-title":"The Wiskott-Aldrich syndrome","volume":"4","author":"Ochs","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jaci.2019.03.012_bib12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jaip.2018.07.009","article-title":"Bleeding and splenectomy in Wiskott-Aldrich syndrome: a single-centre experience","volume":"7","author":"Rivers","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2019.03.012_bib13","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1182\/blood.V82.10.2961.2961","article-title":"Splenectomy and\/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases","volume":"82","author":"Mullen","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib14","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1182\/blood-2012-08-448118","article-title":"Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome","volume":"121","author":"Mahlaoui","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1182\/blood-2014-09-602573","article-title":"Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome\/X-linked thrombocytopenia","volume":"126","author":"Gerrits","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26692","article-title":"Eltrombopag use in a patient with Wiskott-Aldrich syndrome","volume":"64","author":"Gabelli","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jaci.2019.03.012_bib17","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood-2010-11-319376","article-title":"Long-term outcome and lineage-specific chimerism in 194 Wiskott-Aldrich syndrome patients treated by hematopoietic cell transplantation between 1980\u22122009: an international collaborative study","volume":"118","author":"Moratto","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib18","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.jaci.2018.06.042","article-title":"One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years","volume":"142","author":"Elfeky","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib19","doi-asserted-by":"crossref","first-page":"1233151","DOI":"10.1126\/science.1233151","article-title":"Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome","volume":"341","author":"Aiuti","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jaci.2019.03.012_bib20","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1001\/jama.2015.3253","article-title":"Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome","volume":"313","author":"Hacein-Bey Abina","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.jaci.2019.03.012_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1189\/jlb.5MR0617-257R","article-title":"Platelets in Wiskott-Aldrich syndrome: victims or executioners?","volume":"103","author":"Sereni","year":"2018","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2019.03.012_bib22","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jaci.2017.12.1000","article-title":"Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation","volume":"142","author":"Sereni","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib23","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1182\/blood-2009-09-239087","article-title":"X-linked thrombocytopenia (XLT) due to WAS mutations: Clinical characteristics, long-term outcome, and treatment options","volume":"115","author":"Albert","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaut.2013.10.006","article-title":"Wiskott-Aldrich syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans","volume":"50","author":"Castiello","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaci.2019.03.012_bib25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1365-2141.1997.1132938.x","article-title":"Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure","volume":"97","author":"Semple","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2019.03.012_bib26","series-title":"The transmission electron microscope\u2014theory and applications","article-title":"Transmission electron microscopy of platelets from apheresis and buffy-coat-derived platelet concentrates","author":"Neum\u00fcller","year":"2015"},{"key":"10.1016\/j.jaci.2019.03.012_bib27","series-title":"Kelley and Firestein's textbook of rheumatology","first-page":"264","article-title":"Platelets","author":"Boilard","year":"2017"},{"key":"10.1016\/j.jaci.2019.03.012_bib28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/adc.75.5.436","article-title":"Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome","volume":"75","author":"Litzman","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaci.2019.03.012_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13637-017-0059-z","article-title":"From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data","volume":"2017","author":"Vella","year":"2017","journal-title":"EURASIP J Bioinforma Syst Biol"},{"key":"10.1016\/j.jaci.2019.03.012_bib30","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1172\/JCI26989","article-title":"Structure and function of the platelet integrin alphaIIb-beta3","volume":"115","author":"Bennett","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2019.03.012_bib31","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1182\/blood-2008-02-140970","article-title":"Src family tyrosine kinase Lyn mediates VWF\/GPIb-IX-induced platelet activation via the cGMP signaling pathway","volume":"112","author":"Yin","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib32","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/carcin\/bgq114","article-title":"Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein","volume":"31","author":"Fang","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jaci.2019.03.012_bib33","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/bmt.2012.31","article-title":"Outcomes following hematopoietic cell transplantation for Wiskott\u2013Aldrich syndrome","volume":"4731","author":"Shin","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaci.2019.03.012_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10875-014-0105-5","article-title":"Hematopoietic stem cell transplantation for X-linked thrombocytopenia with mutations in the WAS gene","volume":"35","author":"Oshima","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib35","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1182\/blood-2011-03-340711","article-title":"Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome","volume":"119","author":"Astrakhan","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/10799900260286623","article-title":"Role of blood platelets in infection and inflammation","volume":"922","author":"Klinger","year":"2002","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jaci.2019.03.012_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MOH.0b013e3283324f97","article-title":"Dangerous connections: neutrophils and the phagocytic clearance of activated platelets","volume":"17","author":"Manfredi","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jaci.2019.03.012_bib38","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1182\/blood-2008-09-180794","article-title":"Neutrophils phagocytose activated platelets in\u00a0vivo: a phosphatidylserine, P-selectin, and \u03b22 integrin-dependent cell clearance program","volume":"113","author":"Maugeri","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib39","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1182\/blood-2011-02-337337","article-title":"Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia","volume":"118","author":"Maugeri","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib40","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ni.2666","article-title":"Platelet-macrophage partnership in innate immunity and inflammation","volume":"14","author":"Mantovani","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.3A0415-161R","article-title":"Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets","volume":"99","author":"Carestia","year":"2016","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2019.03.012_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2019.03.012_bib43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00005-009-0032-y","article-title":"Platelet influence on T- and B-cell responses","volume":"57","author":"Sowa","year":"2009","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.jaci.2019.03.012_bib44","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1136\/gut.52.10.1435","article-title":"Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients","volume":"52","author":"Danese","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jaci.2019.03.012_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1182\/blood-2003-07-2367","article-title":"Platelet-associated\u00a0CD154 in immune thrombocytopenic purpura","volume":"105","author":"Solanilla","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib46","doi-asserted-by":"crossref","first-page":"22342","DOI":"10.3390\/ijms151222342","article-title":"The signaling role of CD40 ligand in platelet biology and in platelet component transfusion","volume":"15","author":"Aoui","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2019.03.012_bib47","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1046\/j.1365-2141.1999.01637.x","article-title":"Pathological events in platelets of Wiskott-Aldrich syndrome patients","volume":"106","author":"Shcherbina","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2019.03.012_bib48","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1161\/01.ATV.0000145574.90840.7d","article-title":"Reactive oxygen species: players in the platelet game","volume":"24","author":"Kr\u00f6tz","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jaci.2019.03.012_bib49","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/ndt\/gfg185","article-title":"Impaired expression of glycoproteins on resting and stimulated platelets in uraemic patients","volume":"18","author":"Moal","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jaci.2019.03.012_bib50","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1538-7836.2003.00087.x","article-title":"Role of in\u00a0vitro cholesterol depletion in mediating human platelet aggregation","volume":"1","author":"Grgurevich","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jaci.2019.03.012_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9110331","article-title":"Soluble CD40 ligand and oxidative response are reciprocally stimulated during shiga toxin-associated hemolytic uremic syndrome","volume":"9","author":"Abrey Recalde","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jaci.2019.03.012_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.smim.2018.01.003","article-title":"Complement links platelets to innate immunity","volume":"37","author":"Nording","year":"2018","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2019.03.012_bib53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1365-2141.2009.07959.x","article-title":"WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling","volume":"148","author":"Shcherbina","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaci.2019.03.012_bib54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4070\/kcj.2012.42.5.295","article-title":"Mechanisms of platelet activation and integrin \u03b1II\u03b23","volume":"42","author":"Joo","year":"2012","journal-title":"Korean Circ J"},{"key":"10.1016\/j.jaci.2019.03.012_bib55","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.112.132126","article-title":"Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity","volume":"127","author":"Zhou","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2019.03.012_bib56","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1182\/blood-2016-09-738740","article-title":"Platelet HMGB1: the venous clot coordinator","volume":"128","author":"Pawlinski","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.03.012_bib57","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13000-015-0348-3","article-title":"HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-\u03baB and cGMP dependent mechanisms","volume":"10","author":"Yang","year":"2015","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.jaci.2019.03.012_bib58","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbmt.2008.10.007","article-title":"Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment","volume":"15","author":"Ochs","year":"2009","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919304105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919304105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:20:58Z","timestamp":1758792058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674919304105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0091674919304105"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2019.03.012","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lentiviral gene therapy corrects platelet phenotype and function in patients with Wiskott-Aldrich syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2019.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}