{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:11:49Z","timestamp":1780978309760,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Italian Association of Patients with Mastocytosis"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jaci.2019.05.037","type":"journal-article","created":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T10:26:39Z","timestamp":1560594399000},"page":"1106-1111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Flow-mediated dilation shows impaired endothelial function in patients with mastocytosis"],"prefix":"10.1016","volume":"144","author":[{"given":"Tommaso","family":"Bucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"De Feo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cardamone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Triggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2019.05.037_bib1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1158\/0008-5472.CAN-16-2234","article-title":"Advances in the classification and treatment of mastocytosis: current status and outlook toward the future","volume":"77","author":"Valent","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaci.2019.05.037_bib2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.05.037_bib3","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2009-02-205237","article-title":"Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors","volume":"113","author":"Lim","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.05.037_bib4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-pathol-052016-100312","article-title":"Pathogenesis and pathology of mastocytosis","volume":"12","author":"Metcalfe","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jaci.2019.05.037_bib5","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/ajh.24553","article-title":"Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management","volume":"91","author":"Pardanani","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaci.2019.05.037_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2019.05.037_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2018.01.034","article-title":"Mast cells signal their importance in health and disease","volume":"142","author":"Olivera","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.05.037_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2017.06.007","article-title":"Mast cell activation syndromes","volume":"140","author":"Akin","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.05.037_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.iac.2018.04.011","article-title":"Mast cell mediators of significance in clinical practice in mastocytosis","volume":"38","author":"Butterfield","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaci.2019.05.037_bib10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jaci.2013.05.026","article-title":"Gastrointestinal manifestations in mastocytosis: a study of 83 patients","volume":"132","author":"Sokol","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.05.037_bib11","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1182\/blood-2011-07-358432","article-title":"Mast cell modulation of the vascular and lymphatic endothelium","volume":"118","author":"Kunder","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2019.05.037_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/hrt.74.3.247","article-title":"Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility","volume":"74","author":"Sorensen","year":"1995","journal-title":"Br Heart J"},{"key":"10.1016\/j.jaci.2019.05.037_bib13","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.CIR.91.5.1314","article-title":"Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in\u00a0vivo","volume":"91","author":"Joannides","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2019.05.037_bib14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2362.2007.01807.x","article-title":"Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria","volume":"37","author":"Valent","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jaci.2019.05.037_bib15","first-page":"373","article-title":"World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects","volume":"79","author":"World Medical Associaiton","year":"2001","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jaci.2019.05.037_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jaci.2019.05.037_bib17","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2019.05.037_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-2125.2000.00277.x","article-title":"Flow-mediated dilatation","volume":"50","author":"Raitakari","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jaci.2019.05.037_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10554-010-9616-1","article-title":"Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis","volume":"26","author":"Inaba","year":"2010","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jaci.2019.05.037_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5551\/jat.14340","article-title":"Testing endothelial function and its clinical relevance","volume":"20","author":"Poredos","year":"2013","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jaci.2019.05.037_bib21","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/sj.bjp.0706337","article-title":"Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells","volume":"146","author":"Self","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2019.05.037_bib22","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/all.12668","article-title":"Urinary 11beta-PGF2alpha and N-methyl histamine correlate with bone marrow biopsy findings in mast cell disorders","volume":"70","author":"Divekar","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2019.05.037_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40413-016-0094-3","article-title":"Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases","volume":"9","author":"Metcalfe","year":"2016","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaci.2019.05.037_bib24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0625.1999.tb00383.x","article-title":"Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase","volume":"8","author":"Steinhoff","year":"1999","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2019.05.037_bib25","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.4049\/jimmunol.163.9.5064","article-title":"Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in\u00a0vivo","volume":"163","author":"Vergnolle","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2019.05.037_bib26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/HYPERTENSIONAHA.108.125229","article-title":"Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase","volume":"53","author":"Suzuki","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jaci.2019.05.037_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0037-1613205","article-title":"Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells","volume":"88","author":"Houliston","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jaci.2019.05.037_bib28","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.4049\/jimmunol.154.6.2855","article-title":"Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization","volume":"154","author":"Patella","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2019.05.037_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/path.1700650218","article-title":"The relationship of the tissue mast cells to the blood vessels in the rat","volume":"65","author":"Riley","year":"1953","journal-title":"J Pathol Bacteriol"},{"key":"10.1016\/j.jaci.2019.05.037_bib30","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jaci.2019.05.037_bib31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/all.12571","article-title":"Oxidative stress markers are increased in patients with mastocytosis","volume":"70","author":"Gangemi","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2019.05.037_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000087569","article-title":"Role of oxidants in mast cell activation","volume":"87","author":"Suzuki","year":"2005","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.jaci.2019.05.037_bib33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1039\/c4pp00304g","article-title":"An essential role of NAD(P)H oxidase 2 in UVA-induced calcium oscillations in mast cells","volume":"14","author":"Li","year":"2015","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.jaci.2019.05.037_bib34","doi-asserted-by":"crossref","first-page":"e0162831","DOI":"10.1371\/journal.pone.0162831","article-title":"Regulation of reactive oxygen species and the antioxidant protein DJ-1 in mastocytosis","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2019.05.037_bib35","doi-asserted-by":"crossref","first-page":"II11","DOI":"10.1002\/j.1932-8737.1997.tb00007.x","article-title":"Endothelial function and oxidant stress","volume":"20","author":"Harrison","year":"1997","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jaci.2019.05.037_bib36","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/01.RES.0000269183.13937.e8","article-title":"Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB","volume":"100","author":"Donato","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jaci.2019.05.037_bib37","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.108.776823","article-title":"Hot flashes and subclinical cardiovascular disease: findings from the Study of Women's Health Across the Nation Heart Study","volume":"118","author":"Thurston","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2019.05.037_bib38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijcard.2012.09.047","article-title":"Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis","volume":"168","author":"Ras","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jaci.2019.05.037_bib39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.atherosclerosis.2017.11.030","article-title":"Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels","volume":"268","author":"Indhirajanti","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jaci.2019.05.037_bib40","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/ajh.24490","article-title":"Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: a nationwide population-based study","volume":"91","author":"Broesby-Olsen","year":"2016","journal-title":"Am J Hematol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491930764X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491930764X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:20:35Z","timestamp":1758792035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491930764X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S009167491930764X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2019.05.037","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flow-mediated dilation shows impaired endothelial function in patients with mastocytosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2019.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}