{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:52:53Z","timestamp":1774954373301,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jaci.2019.06.048","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T19:38:32Z","timestamp":1567021112000},"page":"931-932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mannitol and the mechanisms behind bronchoconstriction"],"prefix":"10.1016","volume":"144","author":[{"given":"Vibeke","family":"Backer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2019.06.048_bib1","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1378\/chest.10-0116","article-title":"Indirect challenge tests","volume":"138","author":"Anderson","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2019.06.048_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/02770900903584043","article-title":"Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects","volume":"47","author":"Anderson","year":"2010","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2019.06.048_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/cea.12609","article-title":"Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation","volume":"46","author":"Sverrild","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2019.06.048_bib4","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jaci.2019.04.031","article-title":"Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection","volume":"144","author":"S\u00e4fholm","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.06.048_bib5","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jaci.2010.08.028","article-title":"Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study","volume":"126","author":"Sverrild","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.06.048_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2018.09.001","article-title":"Murine models of hapten-induced asthma","volume":"410","author":"Russjan","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.jaci.2019.06.048_bib7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1089\/ars.2016.6863","article-title":"Increased expression of p22phox mediates airway hyperresponsiveness in an experimental model of asthma","volume":"27","author":"Nagaraj","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jaci.2019.06.048_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.imlet.2018.11.012","article-title":"Mouse models of severe asthma for evaluation of therapeutic cytokine targeting","volume":"207","author":"Gubernatorova","year":"2019","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2019.06.048_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/02770909409056767","article-title":"Usefulness of repeated measurements of bronchial hyperresponsiveness for the diagnosis of occupational asthma","volume":"31","author":"Ulrik","year":"1994","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2019.06.048_bib10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/j.1398-9995.2006.01213.x","article-title":"Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells","volume":"61","author":"Gulliksson","year":"2006","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491931108X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167491931108X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:21:56Z","timestamp":1758792116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167491931108X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S009167491931108X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2019.06.048","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mannitol and the mechanisms behind bronchoconstriction","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2019.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2019.04.031","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}