{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:11:15Z","timestamp":1790507475289,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"European Community Respiratory Health Survey"},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["HE 3294\/10-1"],"award-info":[{"award-number":["HE 3294\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Ministry of Health"},{"name":"Cariverona Foundation"},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PS09\/02457"],"award-info":[{"award-number":["PS09\/02457"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PS09\/00716 09\/01511"],"award-info":[{"award-number":["PS09\/00716 09\/01511"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PS09\/02185"],"award-info":[{"award-number":["PS09\/02185"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["PS09\/03190"],"award-info":[{"award-number":["PS09\/03190"]}]},{"name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirurg\u00eda Tor\u00e1cica","award":["SEPAR 1001\/2010"],"award-info":[{"award-number":["SEPAR 1001\/2010"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS PS09\/00716"],"award-info":[{"award-number":["FIS PS09\/00716"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS 09\/01511"],"award-info":[{"award-number":["FIS 09\/01511"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS PS09\/02185"],"award-info":[{"award-number":["FIS PS09\/02185"]}]},{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS PS09\/03190"],"award-info":[{"award-number":["FIS PS09\/03190"]}]},{"name":"Swedish Heart and Lung Foundation"},{"DOI":"10.13039\/501100010234","name":"Swedish Asthma and Allergy Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Association against Lung and Heart Disease"},{"name":"Swedish Research Council for health"},{"name":"Medical Research Council","award":["92091"],"award-info":[{"award-number":["92091"]}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Community\u2019s Seventh Framework Program","award":["FP7\/2007-2011"],"award-info":[{"award-number":["FP7\/2007-2011"]}]},{"name":"European Community\u2019s Seventh Framework Program","award":["211250"],"award-info":[{"award-number":["211250"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jaci.2019.11.040","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T17:59:04Z","timestamp":1579802344000},"page":"834-842.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts"],"prefix":"10.1016","volume":"145","author":[{"given":"Emilie","family":"Burte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Leynaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Benmerad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Elie","family":"Carsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"de Hoogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gormand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nieuwenhuijsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Stempfelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Sunyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"K\u00fcnzli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-9892","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Jacquemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2019.11.040_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2019.11.040_bib2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2222.2011.03891.x","article-title":"Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America","volume":"42","author":"Katelaris","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2019.11.040_bib3","first-page":"24","article-title":"Rhinitis, asthma and respiratory infections among adults in relation to the home environment in multi-family buildings in Sweden","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2019.11.040_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/pcrj.2002.7","article-title":"Allergic rhinitis and its impact on asthma. ARIA. In collaboration with the World Health Organization","volume":"11","author":"Bousquet","year":"2002","journal-title":"Prim Care Respir J"},{"key":"10.1016\/j.jaci.2019.11.040_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000342991","article-title":"Impact of allergic rhinitis symptoms on quality of life in primary care","volume":"160","author":"Bousquet","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib6","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1067\/mai.2000.110151","article-title":"Epidemiologic evidence for asthma and rhinitis comorbidity","volume":"106","author":"Leynaert","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/all.12573","article-title":"Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report","volume":"70","author":"Papadopoulos","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2019.11.040_bib8","first-page":"1583","article-title":"Diagnosing rhinitis: allergic vs. nonallergic","volume":"73","author":"Quillen","year":"2006","journal-title":"Am Fam Phys"},{"key":"10.1016\/j.jaci.2019.11.040_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40629-018-0078-7","article-title":"Air pollutants and primary allergy prevention","volume":"28","author":"Heinrich","year":"2018","journal-title":"Allergo J Int"},{"key":"10.1016\/j.jaci.2019.11.040_bib10","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(08)61446-4","article-title":"Rhinitis and onset of asthma: a longitudinal population-based study","volume":"372","author":"Shaaban","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2019.11.040_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/oem.2007.038349","article-title":"Air pollution and asthma severity in adults","volume":"66","author":"Rage","year":"2009","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.jaci.2019.11.040_bib12","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0140-6736(14)60617-6","article-title":"Outdoor air pollution and asthma","volume":"383","author":"Guarnieri","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2019.11.040_bib13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/aje\/153.7.704","article-title":"Association between air pollution and daily consultations with general practitioners for allergic rhinitis in London, United Kingdom","volume":"153","author":"Hajat","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2019.11.040_bib14","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.scitotenv.2011.04.007","article-title":"Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China","volume":"409","author":"Zhang","year":"2011","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jaci.2019.11.040_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000332964","article-title":"Grass pollen counts, air pollution levels and allergic rhinitis severity","volume":"158","author":"Annesi-Maesano","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/alr.22060","article-title":"The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis","volume":"8","author":"Mady","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2019.11.040_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.envint.2018.03.021","article-title":"Association between air pollution and rhinitis incidence in two European cohorts","volume":"115","author":"Burte","year":"2018","journal-title":"Environ Int"},{"key":"10.1016\/j.jaci.2019.11.040_bib18","first-page":"17","article-title":"EGEA\u2014descriptive characteristics","volume":"29","author":"Kauffmann","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2019.11.040_bib19","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1164\/ajrccm.156.4.12tac9","article-title":"Epidemiological study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy: phenotype issues","volume":"156","author":"Kauffmann","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2019.11.040_bib20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jaci.2009.06.010","article-title":"Phenotypic determinants of uncontrolled asthma","volume":"124","author":"Siroux","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.rmr.2014.12.005","article-title":"Facteurs g\u00e9n\u00e9tiques et environnementaux de l\u2019asthme et de l\u2019allergie : synth\u00e8se des r\u00e9sultats de l\u2019\u00e9tude EGEA","volume":"32","author":"Bouzigon","year":"2015","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.jaci.2019.11.040_bib22","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1183\/09031936.94.07050954","article-title":"The European Community Respiratory Health Survey","volume":"7","author":"Burney","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2019.11.040_bib23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1183\/09031936.02.00046802","article-title":"The European Community Respiratory Health Survey II","volume":"20","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2019.11.040_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4193\/Rhino09.208","article-title":"Numeric score and visual analog scale in assessing seasonal allergic rhinitis severity","volume":"48","author":"Rouve","year":"2010","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2019.11.040_bib25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1183\/09031936.00120810","article-title":"Identifying adult asthma phenotypes using a clustering approach","volume":"38","author":"Siroux","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2019.11.040_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atmosenv.2013.02.037","article-title":"Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe\u2014the ESCAPE project","volume":"72","author":"Beelen","year":"2013","journal-title":"Atmos Environ"},{"key":"10.1016\/j.jaci.2019.11.040_bib27","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/es301948k","article-title":"Development of land use regression models for PM2.5, PM 2.5 absorbance, PM10 and PMcoarse in 20 European study areas: results of the ESCAPE project","volume":"46","author":"Eeftens","year":"2012","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jaci.2019.11.040_bib28","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/ije\/dyy117","article-title":"Analysis of multicentre epidemiological studies: contrasting fixed or random effects modelling and meta-analysis","volume":"47","author":"Basaga\u00f1a","year":"2018","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2019.11.040_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2016.07.005","article-title":"Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data","volume":"151","author":"de Hoogh","year":"2016","journal-title":"Environ Res"},{"key":"10.1016\/j.jaci.2019.11.040_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4168\/aair.2016.8.5.391","article-title":"Climate change and air pollution: effects on respiratory allergy","volume":"8","author":"D\u2019Amato","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2019.11.040_bib31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.18176\/jiaci.0228","article-title":"News on climate change, air pollution and allergic trigger factors of asthma","volume":"28","author":"D\u2019Amato","year":"2018","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1067\/mai.2000.111144","article-title":"Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity","volume":"106","author":"Diaz-Sanchez","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib33","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1021\/acs.est.8b03430","article-title":"Review of acellular assays of ambient particulate matter oxidative potential: methods and relationships with composition, sources, and health effects","volume":"53","author":"Bates","year":"2019","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jaci.2019.11.040_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/ACI.0000000000000235","article-title":"Effects of air pollutants on upper airway disease","volume":"16","author":"Jang","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2019.11.040_bib35","first-page":"1","article-title":"The effect of size-segregated ambient particulate matter on Th1\/Th2-like immune responses in mice","volume":"12","author":"Huang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2019.11.040_bib36","first-page":"95","article-title":"Effects of particulate matter on allergic respiratory diseases","volume":"4","author":"Wu","year":"2018","journal-title":"Chronic Dis Transl Med"},{"key":"10.1016\/j.jaci.2019.11.040_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/09031936.00130014","article-title":"Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis","volume":"45","author":"Adam","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2019.11.040_bib38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1289\/ehp.1408206","article-title":"Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)","volume":"123","author":"Jacquemin","year":"2015","journal-title":"Environ Health Perspect"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919316367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674919316367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:25:29Z","timestamp":1758792329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674919316367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0091674919316367"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2019.11.040","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2019.11.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}