{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:51:14Z","timestamp":1787946674275,"version":"build-2784847793"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV NV18-05-00162"],"award-info":[{"award-number":["AZV NV18-05-00162"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1160 IMPATH"],"award-info":[{"award-number":["SFB 1160 IMPATH"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jaci.2020.02.025","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T03:05:06Z","timestamp":1583809506000},"page":"912-915.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Exhausted phenotype of follicular CD8 T cells in CVID"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-4557","authenticated-orcid":false,"given":"Adam","family":"Klocperk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Friedmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Zoldan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Hausmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Benes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Andrieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Boettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sediva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Bengsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Warnatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.02.025_bib1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ni.3543","article-title":"CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles","volume":"17","author":"Leong","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.02.025_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.01322","article-title":"CXCR5+ CD8 T cells: protective or pathogenic?","volume":"10","author":"Valentine","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.02.025_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10875-014-0052-1","article-title":"Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency","volume":"34","author":"Unger","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2020.02.025_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.clim.2011.07.006","article-title":"Analysis of bulk and virus-specific CD8+ T cells reveals advanced differentiation of CD8+ T cells in patients with common variable immunodeficiency","volume":"141","author":"Kuntz","year":"2011","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2020.02.025_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag2285","article-title":"Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in\u00a0vitro via bispecific antibodies","volume":"9","author":"Petrovas","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2020.02.025_bib6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.immuni.2018.04.026","article-title":"Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells","volume":"48","author":"Bengsch","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.02.025_bib7","first-page":"352","article-title":"T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells","author":"Arbore","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.02.025_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/dna.2016.3571","article-title":"CXCR5+ CD8+ T cells indirectly offer B cell help and are inversely correlated with viral load in chronic hepatitis B infection","volume":"36","author":"Jiang","year":"2017","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.jaci.2020.02.025_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00018","article-title":"Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons?","volume":"4","author":"M\u00fchl","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.02.025_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2020.02.025_bib11","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaci.2020.02.025_bib12","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2020.02.025_bib13","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2020.02.025_bib14","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2020.02.025_bib15","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The Gene Ontology Resource: 20 years and still GOing strong","volume":"47","author":"Carbon","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaci.2020.02.025_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.jaci.2020.02.025_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database Hallmark Gene Set Collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jaci.2020.02.025_bib18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/nar\/gks1055","article-title":"The ConsensusPathDB interaction database: 2013 update","volume":"41","author":"Kamburov","year":"2013","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492030333X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492030333X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:31:17Z","timestamp":1778664677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167492030333X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S009167492030333X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.02.025","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exhausted phenotype of follicular CD8 T cells in CVID","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}