{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:31:43Z","timestamp":1790062303517,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jaci.2020.03.027","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T19:19:22Z","timestamp":1586632762000},"page":"1035-1044.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-700X","authenticated-orcid":false,"given":"Xin","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bircan","family":"Erbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Svanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Axelrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.03.027_bib1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv366","article-title":"Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study","volume":"45","author":"Davey Smith","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2020.03.027_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/jech-2017-209960","article-title":"Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study","volume":"72","author":"Piler","year":"2018","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.jaci.2020.03.027_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaci.2014.07.065","article-title":"Asthma and lower airway disease: prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children","volume":"135","author":"Sordillo","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jaci.2010.08.047","article-title":"Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma","volume":"126","author":"Shaheen","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv366","article-title":"Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study","volume":"45","author":"Magnus","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2020.03.027_bib6","first-page":"118","article-title":"Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort","volume":"65","author":"Perzanowski","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2020.03.027_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1164\/rccm.201005-0757OC","article-title":"Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three","volume":"183","author":"Beasley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/eurpub\/cks061","article-title":"Exposure to paracetamol and asthma symptoms","volume":"23","author":"Gonzalez-Barcala","year":"2013","journal-title":"Eur J Public Health"},{"key":"10.1016\/j.jaci.2020.03.027_bib9","article-title":"Oxidative stress and bronchial asthma in children\u2014causes or consequences?","volume":"5","author":"Milos","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jaci.2020.03.027_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ije\/dyp337","article-title":"Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data","volume":"39","author":"Minelli","year":"2010","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2020.03.027_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/aje\/kwq403","article-title":"Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review","volume":"173","author":"Minelli","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaci.2020.03.027_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1164\/rccm.2112065","article-title":"Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth","volume":"166","author":"Gilliland","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib13","first-page":"341","article-title":"Paracetamol use in early life and asthma: prospective birth cohort study","author":"Lowe","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2020.03.027_bib14","first-page":"25","article-title":"Cohort profile: Melbourne Atopy Cohort study (MACS)","volume":"46","author":"Lowe","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaci.2020.03.027_bib15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jaci.2010.05.006","article-title":"Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: a randomized controlled trial","volume":"128","author":"Lowe","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib16","first-page":"1107","article-title":"American Thoracic Society","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib17","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jaci.2005.08.034","article-title":"Spirometric criteria for asthma: adding further evidence to the debate","volume":"116","author":"Appleton","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib19","article-title":"GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects","volume":"3","author":"Wu","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.03.027_bib20","doi-asserted-by":"crossref","first-page":"15p","DOI":"10.1007\/s11882-018-0771-0","article-title":"Do glutathione S-transferase genes modify the link between indoor air pollution and asthma, allergies, and lung function? A\u00a0systematic review","volume":"18","author":"Dai","year":"2018","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2020.03.027_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/archdischild-2012-303043","article-title":"Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis","volume":"100","author":"Cheelo","year":"2015","journal-title":"Arch Dis Childhood"},{"key":"10.1016\/j.jaci.2020.03.027_bib22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1440-1843.2012.02232.x","article-title":"The Global Lung Initiative 2012 reference values reflect contemporary Australasian spirometry","volume":"17","author":"Hall","year":"2012","journal-title":"Respirology (Carlton, Vic.)"},{"key":"10.1016\/j.jaci.2020.03.027_bib23","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2020.03.027_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.chest.2018.08.1079","article-title":"Interaction of glutathione S-transferase M1, T1, and P1 genes with early life tobacco smoke exposure on lung function in adolescents","volume":"155","author":"Dai","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2020.03.027_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/02770903.2016.1194431","article-title":"The association between paracetamol and asthma is still under debate","volume":"54","author":"Lourido-Cebreiro","year":"2017","journal-title":"J Asthma"},{"key":"10.1016\/j.jaci.2020.03.027_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/thx.50.4.399","article-title":"Acute lung injury in fulminant hepatic failure following paracetamol poisoning","volume":"50","author":"Baudouin","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2020.03.027_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2222.2009.03378.x","article-title":"The role\u00a0of paracetamol in the pathogenesis of asthma","volume":"40","author":"Farquhar","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.03.027_bib28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.anai.2013.03.008","article-title":"Original article: effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes","volume":"110","author":"Kang","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2010.08.023","article-title":"Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood","volume":"126","author":"Schnabel","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.03.027_bib30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/thx.54.12.1119","article-title":"Gender differences in airway behaviour over the human life span","volume":"54","author":"Becklake","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2020.03.027_bib31","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A longitudinal, population-based, cohort study of childhood asthma followed to adulthood","volume":"349","author":"Sears","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2015.4577","article-title":"Prenatal and perinatal determinants of lung health and disease in early life: a National Heart, Lung, and Blood Institute workshop report","volume":"170","author":"Manuck","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaci.2020.03.027_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ng0110-14","article-title":"Lung function and airway diseases","volume":"42","author":"Weiss","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2020.03.027_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S2213-2600(18)30100-0","article-title":"Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life","volume":"6","author":"Bui","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaci.2020.03.027_bib35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.aller.2016.10.014","article-title":"Original article: prenatal paracetamol use and asthma in childhood: a systematic review and meta-analysis","volume":"45","author":"Fan","year":"2017","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.jaci.2020.03.027_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/aje\/154.2.95","article-title":"GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review","volume":"154","author":"Geisler","year":"2001","journal-title":"Am J Epidemiol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920304346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920304346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:25:03Z","timestamp":1758792303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674920304346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0091674920304346"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.03.027","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life acetaminophen exposure, glutathione S-transferase genes, and development of adolescent asthma in a high-risk birth cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}