{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:30:47Z","timestamp":1790879447570,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jaci.2020.06.015","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T20:42:28Z","timestamp":1593463348000},"page":"361-367.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Unique skin abnormality in patients with peanut allergy but no atopic dermatitis"],"prefix":"10.1016","volume":"147","author":[{"given":"Evgeny","family":"Berdyshev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Goleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bronova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Sofia","family":"Bronoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce C.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Ramirez-Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Crumrine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-3844","authenticated-orcid":false,"given":"Donald Y.M.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.06.015_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.15585\/mmwr.mm6838a6","article-title":"QuickStats: Percentage of children aged <18 years with a food or digestive allergy in the past 12 months,\u2217 by age group - National Health Interview Survey, 2007-2018\u2020","volume":"68","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jaci.2020.06.015_bib2","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1172\/JCI75660","article-title":"Skin exposure promotes a Th2-dependent sensitization to peanut allergens","volume":"124","author":"Tordesillas","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.06.015_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11882-017-0674-5","article-title":"The skin as a route of allergen exposure: part I. Immune components and mechanisms","volume":"17","author":"Smith","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaci.2020.06.015_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaci.2009.05.042","article-title":"Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen","volume":"124","author":"Oyoshi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.06.015_bib5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.jaci.2018.02.003","article-title":"Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation","volume":"141","author":"Walker","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.06.015_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cea.12406","article-title":"Which infants with eczema are at risk of food allergy? Results from a population-based cohort","volume":"45","author":"Martin","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.06.015_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMoa013536","article-title":"Factors associated with the development of peanut allergy in childhood","volume":"348","author":"Lack","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.06.015_bib8","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.jaip.2019.11.036","article-title":"Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age","volume":"8","author":"Miyaji","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2020.06.015_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.anai.2019.03.019","article-title":"The prevalence of atopic dermatitis in children with food allergy","volume":"122","author":"Samady","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.06.015_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav2685","article-title":"The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype","volume":"11","author":"Leung","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2020.06.015_bib11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"10.1016\/j.jaci.2020.06.015_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2020.06.015_bib13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1398-9995.2010.02540.x","article-title":"Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity","volume":"66","author":"Kezic","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.06.015_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1084\/jem.158.1.84","article-title":"Mechanism of immune suppression by ultraviolet irradiation in\u00a0vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology","volume":"158","author":"De Fabo","year":"1983","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.06.015_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-4615-1971-3_47","article-title":"The role of cis-urocanic acid in UVB-induced immunosuppression","volume":"378","author":"Lappin","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaci.2020.06.015_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jid.2010.276","article-title":"Urocanic acid in the skin: a mixed blessing?","volume":"131","author":"Gibbs","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.06.015_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbalip.2013.09.011","article-title":"Formation and functions of the corneocyte lipid envelope (CLE)","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2020.06.015_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2020.06.015_bib19","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1194\/jlr.P030338","article-title":"Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients","volume":"53","author":"Janssens","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jaci.2020.06.015_bib20","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/jid.2010.161","article-title":"Changes in the ceramide profile of atopic dermatitis patients","volume":"130","author":"Ishikawa","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.06.015_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/exd.12293","article-title":"The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients","volume":"23","author":"van Smeden","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2020.06.015_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1289\/ehp.1306720","article-title":"Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish men","volume":"122","author":"Joensen","year":"2014","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaci.2020.06.015_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI124608","article-title":"Epithelial barrier repair and prevention of allergy","volume":"129","author":"Goleva","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.06.015_bib24","doi-asserted-by":"crossref","first-page":"17420","DOI":"10.1073\/pnas.0603119103","article-title":"Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor","volume":"103","author":"Walterscheid","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.06.015_bib25","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.jaci.2018.08.037","article-title":"Direct infant UV light exposure is associated with eczema and immune development","volume":"143","author":"Rueter","year":"2019","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920308927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920308927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:27:31Z","timestamp":1758792451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674920308927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0091674920308927"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.06.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unique skin abnormality in patients with peanut allergy but no atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}