{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:36:18Z","timestamp":1790840178941,"version":"4.1.0"},"reference-count":163,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Spanish Ministry of Economy and Competitiveness","doi-asserted-by":"publisher","award":["SAF2017-82886-R"],"award-info":[{"award-number":["SAF2017-82886-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ram\u00f3n Areces Foundation \u201cCiencias de la Vida y la Salud\u201d"},{"name":"Ayudas Fundaci\u00f3n BBVA a Equipos de Investigaci\u00f3n Cient\u00edfica"},{"name":"\u201cLa Caixa\u201d Banking Foundation","award":["HR17-00016"],"award-info":[{"award-number":["HR17-00016"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jaci.2020.11.023","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T11:04:57Z","timestamp":1606561497000},"page":"2030-2042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Dissecting the complexity of \u03b3\u03b4 T-cell subsets in skin homeostasis, inflammation, and malignancy"],"prefix":"10.1016","volume":"147","author":[{"given":"Raquel","family":"Castillo-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danay","family":"Cibrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"S\u00e1nchez-Madrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.11.023_bib1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41577-019-0162-3","article-title":"T cells and the skin: from protective immunity to inflammatory skin disorders","volume":"19","author":"Ho","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"\u03b3\u03b4 T cells in homeostasis and host defence of epithelial barrier tissues","volume":"17","author":"Nielsen","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/ni.2585","article-title":"Deficiency in IL-17-committed V\u03b34+ \u03b3\u03b4 T cells in a spontaneous Sox13-mutant CD45.1+ congenic mouse substrain provides protection from dermatitis","volume":"14","author":"Gray","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib5","doi-asserted-by":"crossref","first-page":"10917","DOI":"10.1073\/pnas.1818256116","article-title":"Clonal V\u03b36+V\u03b44+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection","volume":"116","author":"Marchitto","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nri3904","article-title":"\u03b3\u03b4 T cells in cancer","volume":"15","author":"Silva-Santos","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2017.01.007","article-title":"Thymic determinants of \u03b3\u03b4 T cell differentiation","volume":"38","author":"Munoz-Ruiz","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-\u03b3- and interleukin 17-producing \u03b3\u03b4 T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2008.04.022","article-title":"Thymic selection determines \u03b3\u03b4 T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon \u03b3","volume":"29","author":"Jensen","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib10","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/eji.200939922","article-title":"CCR6 and NK1.1 distinguish between IL-17A and IFN-\u03b3-producing \u03b3\u03b4 effector T cells","volume":"39","author":"Haas","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/322836a0","article-title":"Diversity of murine \u03b3 genes and expression in fetal and adult T lymphocytes","volume":"322","author":"Heilig","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.11.023_bib12","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0092-8674(88)90139-0","article-title":"Limited diversity of \u03b3\u03b4 antigen receptor genes of Thy-1+ dendritic epidermal cells","volume":"55","author":"Asarnow","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2020.11.023_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1084\/jem.20101824","article-title":"Cutaneous immunosurveillance by self-renewing dermal \u03b3\u03b4 T cells","volume":"208","author":"Sumaria","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib14","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.4049\/jimmunol.1100427","article-title":"Cutting edge: Identification of a motile IL-17-producing \u03b3\u03b4 T cell population in the dermis","volume":"186","author":"Gray","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/jid.2014.289","article-title":"The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy","volume":"135","author":"Tong","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib16","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1084\/jem.20181206","article-title":"Epidermal \u03b3\u03b4 T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult","volume":"215","author":"Gentek","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib17","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1126\/science.1828619","article-title":"Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors","volume":"252","author":"Havran","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.11.023_bib18","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1038\/ncomms12080","article-title":"IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin","volume":"7","author":"Dalessandri","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2011.04.018","article-title":"Skint-1 identifies a common molecular mechanism for the development of interferon-\u03b3-secreting versus interleukin-17-secreting \u03b3\u03b4 T cells","volume":"35","author":"Turchinovich","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib20","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.4049\/jimmunol.1301689","article-title":"IL-1beta-dependent activation of dendritic epidermal T cells in contact hypersensitivity","volume":"192","author":"Nielsen","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jid.2016.08.013","article-title":"Emerging skin T-cell functions in response to environmental insults","volume":"137","author":"Suwanpradid","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-2478(02)00007-X","article-title":"Seeding of dendritic epidermal T cells in the neonatal skin is reduced in 129 strain of mice","volume":"81","author":"Lee","year":"2002","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2020.11.023_bib23","article-title":"Dermal \u03b3\u03b4 T cells do not freely re-circulate out of skin and produce IL-17 to promote neutrophil infiltration during primary contact hypersensitivity","volume":"12","author":"Jiang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.11.023_bib24","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.celrep.2019.05.064","article-title":"Single-cell transcriptomics identifies the adaptation of Scart1+ V\u03b36+ T cells to skin residency as activated effector cells","volume":"27","author":"Tan","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib25","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1038\/ncomms4986","article-title":"Differential developmental requirement and peripheral regulation for dermal V\u03b34 and V\u03b36T17 cells in health and inflammation","volume":"5","author":"Cai","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/jid.2014.516","article-title":"Dermal V\u03b34+ \u03b3\u03b4 T cells possess a migratory potency to the draining lymph nodes and modulate CD8+ T-cell activity through TNF-alpha production","volume":"135","author":"Nakamizo","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12026-012-8364-9","article-title":"A canonical V\u03b34V\u03b44+ \u03b3\u03b4 T cell population with distinct stimulation requirements which promotes the Th17 response","volume":"55","author":"Roark","year":"2013","journal-title":"Immunol Res"},{"key":"10.1016\/j.jaci.2020.11.023_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2019.09.025","article-title":"Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation","volume":"145","author":"Cibrian","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib29","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1073\/pnas.1508990112","article-title":"Inflammation induces dermal V\u03b34+ \u03b3\u03b4T17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses","volume":"112","author":"Ramirez-Valle","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib30","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1002\/eji.201545883","article-title":"Dermal IL-17-producing \u03b3\u03b4 T cells establish long-lived memory in the skin","volume":"45","author":"Hartwig","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib31","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.15252\/embr.201744200","article-title":"IL-23 drives differentiation of peripheral \u03b3\u03b417 T cells from adult bone marrow-derived precursors","volume":"18","author":"Papotto","year":"2017","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib32","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.4049\/jimmunol.1700287","article-title":"IL-1beta and IL-23 promote extrathymic commitment of CD27+CD122- \u03b3\u03b4 T cells to \u03b3\u03b4T17 cells","volume":"199","author":"Muschaweckh","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib33","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.0903539","article-title":"Cutting edge: spontaneous development of IL-17-producing \u03b3\u03b4 T cells in the thymus occurs via a TGF-beta 1-dependent mechanism","volume":"184","author":"Do","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib34","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.1073\/pnas.1204327109","article-title":"Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing \u03b3\u03b4 cells","volume":"109","author":"Michel","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib35","doi-asserted-by":"crossref","first-page":"9692","DOI":"10.1073\/pnas.1420741112","article-title":"IL-15 receptor alpha signaling constrains the development of IL-17-producing \u03b3\u03b4 T cells","volume":"112","author":"Colpitts","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10087","article-title":"The NF\u03baB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing \u03b3\u03b4 T cells","volume":"4","author":"Mair","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.jaci.2020.11.023_bib37","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1073\/pnas.93.14.7172","article-title":"Interleukin 7 receptor-deficient mice lack \u03b3\u03b4 T cells","volume":"93","author":"Maki","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib38","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.4049\/jimmunol.168.12.6486","article-title":"Developmental and functional defects of thymic and epidermal V \u03b3 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice","volume":"168","author":"De Creus","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib39","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.3390\/ijms21062249","article-title":"AHR signaling dampens inflammatory signature in neonatal skin \u03b3\u03b4 T cells","volume":"21","author":"Merches","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2020.11.023_bib40","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.4049\/jimmunol.1100912","article-title":"Aryl hydrocarbon receptor is critical for homeostasis of invariant \u03b3\u03b4 T cells in the murine epidermis","volume":"187","author":"Kadow","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib41","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2013.01.010","article-title":"A network of high-mobility group box transcription factors programs innate interleukin-17 production","volume":"38","author":"Malhotra","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib42","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.4049\/jimmunol.1500939","article-title":"PLZF controls the development of fetal-derived IL-17+V\u03b36+ \u03b3\u03b4 T cells","volume":"195","author":"Lu","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41590-018-0274-0","article-title":"The transcription factor c-Maf is essential for the commitment of IL-17-producing \u03b3\u03b4 T cells","volume":"20","author":"Zuberbuehler","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib44","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1182\/blood-2011-02-334995","article-title":"Notch-Hes1 pathway is required for the development of IL-17-producing \u03b3\u03b4 T cells","volume":"118","author":"Shibata","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2020.11.023_bib45","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1038\/s41467-017-02225-5","article-title":"HEB is required for the specification of fetal IL-17-producing \u03b3\u03b4 T cells","volume":"8","author":"In","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib46","doi-asserted-by":"crossref","first-page":"E556","DOI":"10.1073\/pnas.1412058112","article-title":"Effector V\u03b39V\u03b42 T cells dominate the human fetal \u03b3\u03b4 T-cell repertoire","volume":"112","author":"Dimova","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/j.1460-2075.1991.tb07923.x","article-title":"Regulated expression and structure of T cell receptor gamma\/delta transcripts in human thymic ontogeny","volume":"10","author":"McVay","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/j.jaci.2020.11.023_bib48","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.4049\/jimmunol.157.7.2873","article-title":"Extrathymic origin of human gamma delta T cells during fetal development","volume":"157","author":"McVay","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2006.00479.x","article-title":"Nonpeptide antigens, presentation mechanisms, and immunological memory of human V\u03b32V\u03b42 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens","volume":"215","author":"Morita","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2020.11.023_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1084\/jem.20021500","article-title":"Human T cell receptor \u03b3\u03b4 cells recognize endogenous mevalonate metabolites in tumor cells","volume":"197","author":"Gober","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib51","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.immuni.2020.02.014","article-title":"Butyrophilin-2A1 directly binds germline-encoded regions of the V\u03b39V\u03b42\u00a0TCR\u00a0and is essential for phosphoantigen sensing","volume":"52","author":"Karunakaran","year":"2020","journal-title":"Immunity"},{"issue":"6478","key":"10.1016\/j.jaci.2020.11.023_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin 2A1 is essential for phosphoantigen reactivity by \u03b3\u03b4 T cells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.11.023_bib53","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","article-title":"The\u00a0intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens\u00a0to\u00a0mediate activation of human V\u03b39V\u03b42 T cells","volume":"40","author":"Sandstrom","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib54","doi-asserted-by":"crossref","first-page":"E7311","DOI":"10.1073\/pnas.1707547114","article-title":"Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V\u03b39V\u03b42 T cell activation","volume":"114","author":"Gu","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib55","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1073\/pnas.1701237115","article-title":"Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing \u03b3\u03b4 T cell biology","volume":"115","author":"Vantourout","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib56","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1128\/JVI.78.9.4927-4930.2004","article-title":"Intraepithelial \u03b3\u03b4 T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2","volume":"78","author":"Nishimura","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.jaci.2020.11.023_bib57","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1073\/pnas.96.12.6879","article-title":"Broad tumor-associated expression and recognition by tumor-derived \u03b3\u03b4 T cells of MICA and MICB","volume":"96","author":"Groh","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib58","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/ni.2713","article-title":"CD1d-lipid antigen recognition by the \u03b3\u03b4 TCR","volume":"14","author":"Uldrich","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib59","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1182\/blood-2011-02-339135","article-title":"Differentiation of human peripheral blood V\u03b41+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells","volume":"118","author":"Correia","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2020.11.023_bib60","doi-asserted-by":"crossref","DOI":"10.4161\/onci.22892","article-title":"Tumor cell recognition by \u03b3\u03b4 T lymphocytes: T-cell receptor vs. NK-cell receptors","volume":"2","author":"Correia","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jaci.2020.11.023_bib61","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1038\/ncomms14760","article-title":"Clonal selection in the human V\u03b41 T cell repertoire indicates \u03b3\u03b4 TCR-dependent adaptive immune surveillance","volume":"8","author":"Davey","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib62","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jhep.2018.05.007","article-title":"Human liver infiltrating \u03b3\u03b4 T cells are composed of clonally expanded circulating and tissue-resident populations","volume":"69","author":"Hunter","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib63","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4049\/jimmunol.1300121","article-title":"Cutting edge: CD1d restriction and Th1\/Th2\/Th17 cytokine secretion by human V\u03b43 T cells","volume":"191","author":"Mangan","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib64","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/art.33507","article-title":"Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive gamma\/delta T cells in patients with active ankylosing spondylitis","volume":"64","author":"Kenna","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2020.11.023_bib65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1182\/blood-2011-01-331298","article-title":"Differentiation, phenotype, and function of interleukin-17-producing human V\u03b39V\u03b42 T cells","volume":"118","author":"Caccamo","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2020.11.023_bib66","doi-asserted-by":"crossref","first-page":"107773","DOI":"10.1016\/j.celrep.2020.107773","article-title":"High CD26 and low CD94 expression identifies an IL-23 responsive V\u03b42+ T cell subset with a MAIT cell-like transcriptional profile","volume":"31","author":"Wragg","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib67","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.1069639","article-title":"A role for skin \u03b3\u03b4 T cells in wound repair","volume":"296","author":"Jameson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.11.023_bib68","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ni1152","article-title":"Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1","volume":"6","author":"Sharp","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib69","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1038\/s41598-017-05950-5","article-title":"Weakened IL-15 Production and impaired mTOR activation alter dendritic epidermal T cell homeostasis in diabetic mice","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib70","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/sj.jid.5700120","article-title":"Environmentally responsive and reversible regulation of epidermal barrier function by \u03b3\u03b4 T cells","volume":"126","author":"Girardi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib71","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nm.3181","article-title":"Fgf9 from dermal \u03b3\u03b4 T cells induces hair follicle neogenesis after wounding","volume":"19","author":"Gay","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib72","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3389\/fimmu.2018.01099","article-title":"Functions of V\u03b34 T cells and dendritic epidermal T cells on skin wound healing","volume":"9","author":"Li","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158993","article-title":"Dermal \u03b3\u03b4 T-cells can be activated by mitochondrial damage-associated molecular patterns","volume":"11","author":"Schwacha","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.11.023_bib74","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1523-1747.2001.01250.x","article-title":"The TCR-\u03b4 repertoire in normal human skin is restricted and distinct from\u00a0the\u00a0TCR-\u03b4 repertoire in the peripheral blood","volume":"116","author":"Holtmeier","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib75","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.4049\/jimmunol.176.7.4331","article-title":"Homing and function of human skin \u03b3\u03b4 T cells\u00a0and\u00a0NK cells: relevance for tumor surveillance","volume":"176","author":"Ebert","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib76","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1084\/jem.20081787","article-title":"A role for human skin-resident T cells in wound healing","volume":"206","author":"Toulon","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib77","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","volume":"361","author":"Nestle","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib78","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/jid.2012.260","article-title":"CCR6 is required for epidermal trafficking of \u03b3\u03b4-T cells in an IL-23-induced model of psoriasiform dermatitis","volume":"133","author":"Mabuchi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib79","doi-asserted-by":"crossref","first-page":"13466","DOI":"10.1038\/ncomms13466","article-title":"IL-12\u00a0protects from psoriasiform skin inflammation","volume":"7","author":"Kulig","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib80","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948647","article-title":"STAT3 but not STAT4 is critical for \u03b3\u03b4T17 cell responses and skin inflammation","volume":"20","author":"Agerholm","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib81","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.celrep.2019.05.019","article-title":"Differential roles of the mTOR-STAT3 signaling in dermal \u03b3\u03b4 T cell effector function in skin inflammation","volume":"27","author":"Cai","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib82","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI95837","article-title":"\u03b3\u03b4TCR recruits the Syk\/PI3K axis to drive proinflammatory differentiation program","volume":"128","author":"Muro","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.11.023_bib83","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.4049\/jimmunol.1103173","article-title":"Blockade\u00a0of\u00a0phosphatidylinositol 3-kinase PI3K\u03b4 or PI3K\u03b3 reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis","volume":"189","author":"Roller","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib84","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chom.2010.01.005","article-title":"Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma\/delta T cells","volume":"7","author":"Duan","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaci.2020.11.023_bib85","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.4049\/jimmunol.1800104","article-title":"Syndecan-1 regulates psoriasiform dermatitis by controlling homeostasis of IL-17-producing \u03b3\u03b4 T cells","volume":"201","author":"Jaiswal","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib86","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4049\/jimmunol.1500448","article-title":"Cutting Edge: PD-1 regulates imiquimod-induced psoriasiform dermatitis through inhibition of IL-17A expression by innate \u03b3\u03b4-low T cells","volume":"195","author":"Imai","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib87","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.celrep.2019.09.003","article-title":"CD109 restrains activation of cutaneous IL-17-producing \u03b3\u03b4 T cells by commensal microbiota","volume":"29","author":"Zhang","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib88","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41591-018-0003-0","article-title":"Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib89","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.3389\/fimmu.2019.02285","article-title":"Targeting T cell metabolism in inflammatory skin disease","volume":"10","author":"von Meyenn","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmed.2020.04.004","article-title":"Metabolic pathways that control skin homeostasis and inflammation","author":"Cibrian","year":"2020","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib91","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3504","article-title":"CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis","volume":"17","author":"Cibrian","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib92","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","volume":"2","author":"Greb","year":"2016","journal-title":"Psoriasis. Nat Rev Dis Primers"},{"key":"10.1016\/j.jaci.2020.11.023_bib93","doi-asserted-by":"crossref","first-page":"14076","DOI":"10.1038\/s41598-017-14292-1","article-title":"High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing \u03b3\u03b4 T cells","volume":"7","author":"Nakamizo","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.11.023_bib94","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12944-019-1115-3","article-title":"New insights into different adipokines in linking the pathophysiology of obesity and psoriasis","volume":"18","author":"Kong","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jaci.2020.11.023_bib95","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1038\/ncomms8687","article-title":"Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from \u03b3\u03b4-T cells","volume":"6","author":"Shibata","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.023_bib96","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1038\/jid.2015.316","article-title":"circadian gene clock regulates psoriasis-like skin inflammation in mice","volume":"135","author":"Ando","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib97","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.4049\/jimmunol.1100804","article-title":"Identification of a novel proinflammatory human skin-homing V\u03b39V\u03b42 T cell subset with a potential role in psoriasis","volume":"187","author":"Laggner","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib98","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic dermatitis: a disease of altered skin barrier and immune dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2020.11.023_bib99","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2332\/allergolint.13-RAI-0564","article-title":"New insights into atopic dermatitis: role of skin barrier and immune dysregulation","volume":"62","author":"Leung","year":"2013","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaci.2020.11.023_bib100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51188","article-title":"Neonatal-derived IL-17 producing dermal \u03b3\u03b4 T cells are required to prevent spontaneous atopic dermatitis","volume":"9","author":"Spidale","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.jaci.2020.11.023_bib101","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.11.023_bib102","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/eji.201545675","article-title":"Accumulation and activation of epidermal \u03b3\u03b4 T cells in a mouse model of chronic dermatitis is not required for the inflammatory phenotype","volume":"45","author":"Sulcova","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib103","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.1991.tb02950.x","article-title":"T cell receptor \u03b3\u03b4 bearing cells are decreased in the peripheral blood of patients with atopic diseases","volume":"86","author":"Schauer","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib104","doi-asserted-by":"crossref","first-page":"7736","DOI":"10.4049\/jimmunol.176.12.7736","article-title":"NK cells and \u03b3\u03b4+ T cells are phenotypically and functionally defective due to preferential apoptosis in patients with atopic dermatitis","volume":"176","author":"Katsuta","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2005.02813.x","article-title":"Analysis of circulating \u03b3\u03b4 T cells in children affected by IgE-associated and non-IgE-associated allergic atopic eczema\/dermatitis syndrome","volume":"141","author":"Cairo","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12016-018-8713-0","article-title":"Irritant contact dermatitis","volume":"56","author":"Bains","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib107","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1523-1747.2002.01830.x","article-title":"\u0393\u03b4T cells regulate the development of hapten-specific CD8+ effector T cells in contact hypersensitivity responses","volume":"119","author":"Guan","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib108","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4049\/jimmunol.1600848","article-title":"Occludin Expression in epidermal \u03b3\u03b4 T Cells in response to epidermal stress causes them to migrate into draining lymph nodes","volume":"199","author":"Saito","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib109","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/jid.2015.23","article-title":"NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity","volume":"135","author":"Nielsen","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib110","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.20012000","article-title":"Resident skin-specific \u03b3\u03b4 T cells provide local, nonredundant regulation of cutaneous inflammation","volume":"195","author":"Girardi","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib111","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ni.2240","article-title":"Body-barrier surveillance by epidermal \u03b3\u03b4 TCRs","volume":"13","author":"Chodaczek","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib112","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.4049\/jimmunol.1701389","article-title":"Cutting Edge: Nqo1 regulates irritant contact hypersensitivity against croton oil through maintenance of dendritic epidermal T cells","volume":"200","author":"Kitajima","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib113","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/cod.12040","article-title":"Characterization of the T cell response in allergic contact dermatitis caused by corticosteroids","volume":"68","author":"Baeck","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2020.11.023_bib114","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF00372140","article-title":"\u03b3\u03b4 T-cell receptor-positive cells of human skin. II. Appearance in delayed-type hypersensitivity reaction","volume":"285","author":"Fujita","year":"1993","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaci.2020.11.023_bib115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF01262321","article-title":"Gamma\/delta T cells and human skin reactivity to heavy metals","volume":"287","author":"Nordlind","year":"1995","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaci.2020.11.023_bib116","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/cod.12043","article-title":"CD4+ T cells producing interleukin (IL)-17, IL-22 and interferon-\u03b3 are major effector T cells in nickel allergy","volume":"68","author":"Dyring-Andersen","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2020.11.023_bib117","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri3010","article-title":"Immunity against Staphylococcus aureus cutaneous infections","volume":"11","author":"Miller","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib118","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.jaci.2016.07.001","article-title":"IL-22 derived from \u03b3\u03b4 T cells restricts Staphylococcus aureus infection of mechanically injured skin","volume":"138","author":"Malhotra","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib119","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/IAI.01061-15","article-title":"nonredundant roles of interleukin-17A (IL-17A) and IL-22 in murine host defense against cutaneous and hematogenous infection due to methicillin-resistant Staphylococcus aureus","volume":"83","author":"Chan","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.jaci.2020.11.023_bib120","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI40891","article-title":"IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice","volume":"120","author":"Cho","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.11.023_bib121","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/ni.2637","article-title":"Signaling via the IL-20 receptor inhibits cutaneous production of IL-1beta and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus","volume":"14","author":"Myles","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib122","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.179.10.6933","article-title":"Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in\u00a0vivo","volume":"179","author":"Miller","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib123","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.chom.2017.10.006","article-title":"Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-mediated T cell responses","volume":"22","author":"Liu","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaci.2020.11.023_bib124","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1002\/eji.200838366","article-title":"Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR \u03b3\u03b4 cells","volume":"38","author":"Kistowska","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib125","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1172\/JCI200113584","article-title":"Antibacterial effect of human V gamma 2V delta 2 T cells in\u00a0vivo","volume":"108","author":"Wang","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.11.023_bib126","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.4049\/jimmunol.2000143","article-title":"Activation of human V\u03b42+ \u03b3\u03b4 T Cells by Staphylococcus aureus promotes enhanced anti-staphylococcal adaptive immunity","volume":"205","author":"Cooper","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib127","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1172\/JCI40926","article-title":"Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice","volume":"120","author":"Tomura","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.11.023_bib128","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4049\/jimmunol.161.2.1045","article-title":"Bacille Calmette-Guerin vaccination enhances human \u03b3\u03b4 T cell responsiveness to mycobacteria suggestive of a memory-like phenotype","volume":"161","author":"Hoft","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077334","article-title":"The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFN\u03b3 response in Bacille Calmette-Guerin (BCG)-immunized infants","volume":"8","author":"Zufferey","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.11.023_bib130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.it.2016.04.007","article-title":"skin immunity to Candida albicans","volume":"37","author":"Kashem","year":"2016","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib131","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib132","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.4049\/jimmunol.1403066","article-title":"Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by V\u03b41 T cells","volume":"194","author":"Maher","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib133","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003892","article-title":"Malassezia yeasts: how many species infect humans and animals?","volume":"10","author":"Cabanes","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2020.11.023_bib134","doi-asserted-by":"crossref","DOI":"10.1080\/19381980.2017.1361573","article-title":"Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial","volume":"9","author":"Kamamoto","year":"2017","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.jaci.2020.11.023_bib135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.chom.2019.02.002","article-title":"The skin commensal yeast Malassezia triggers a type 17 response that coordinates anti-fungal immunity and exacerbates skin inflammation","volume":"25","author":"Sparber","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaci.2020.11.023_bib136","doi-asserted-by":"crossref","first-page":"16465","DOI":"10.1073\/pnas.2003022117","article-title":"Immunity to commensal skin fungi promotes psoriasiform skin inflammation","volume":"117","author":"Hurabielle","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.11.023_bib137","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.4049\/jimmunol.1402438","article-title":"Dermal-resident versus recruited \u03b3\u03b4 T cell response to cutaneous vaccinia virus infection","volume":"194","author":"Woodward Davis","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib138","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1086\/444423","article-title":"Flow-cytometric detection of vaccinia-induced memory effector CD4+, CD8+, and \u03b3\u03b4 TCR+ T cells capable of antigen-specific expansion and effector functions","volume":"192","author":"Abate","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jaci.2020.11.023_bib139","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.185.11.1969","article-title":"T cell receptor-gamma\/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis","volume":"185","author":"Sciammas","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib140","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1167\/iovs.19-27810","article-title":"CCR6-positive \u03b3\u03b4 T cells provide protection against intracorneal HSV-1 infection","volume":"60","author":"Fitzpatrick","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jaci.2020.11.023_bib141","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.0904106","article-title":"Herpes simplex virus infects skin \u03b3\u03b4 T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulation","volume":"185","author":"Puttur","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib142","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.4049\/jimmunol.153.11.5133","article-title":"Recognition and destruction of virus-infected cells by human \u03b3\u03b4 CTL","volume":"153","author":"Bukowski","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib143","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jamadermatol.2019.3353","article-title":"Age-specific incidence of melanoma in the United States","volume":"156","author":"Paulson","year":"2020","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaci.2020.11.023_bib144","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1126\/science.1063916","article-title":"Regulation of cutaneous malignancy by \u03b3\u03b4 T cells","volume":"294","author":"Girardi","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.11.023_bib145","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.20021282","article-title":"The distinct contributions of murine T cell receptor (TCR)\u03b3\u03b4+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer","volume":"198","author":"Girardi","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib146","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jlb.55.3.379","article-title":"Inhibitory effect of a dendritic epidermal T cell line on K1735 melanoma cells in\u00a0vivo and in\u00a0vitro","volume":"55","author":"Love-Schimenti","year":"1994","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jaci.2020.11.023_bib147","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ni1556","article-title":"Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis","volume":"9","author":"Strid","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib148","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1084\/jem.20030584","article-title":"\u03b3\u03b4 T cells provide an early source of interferon \u03b3 in tumor immunity","volume":"198","author":"Gao","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.023_bib149","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/eji.200940157","article-title":"Tumor-infiltrating IL-17-producing \u03b3\u03b4 T cells support the progression of tumor by promoting angiogenesis","volume":"40","author":"Wakita","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib150","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2014.03.013","article-title":"\u03b3\u03b4T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer","volume":"40","author":"Wu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2020.11.023_bib151","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/cas.13005","article-title":"IL-17A-producing CD30+ V\u03b41 T cells drive inflammation-induced cancer progression","volume":"107","author":"Kimura","year":"2016","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jaci.2020.11.023_bib152","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.4161\/onci.21659","article-title":"Analysis of V\u03b41 T cells in clinical grade melanoma-infiltrating lymphocytes","volume":"1","author":"Donia","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jaci.2020.11.023_bib153","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049878","article-title":"Characterization of human \u03b3\u03b4 T lymphocytes infiltrating primary malignant melanomas","volume":"7","author":"Cordova","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.11.023_bib154","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3389\/fimmu.2017.01401","article-title":"Current\u00a0advances in \u03b3\u03b4 T cell-based tumor immunotherapy","volume":"8","author":"Lo Presti","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib155","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fimmu.2018.00800","article-title":"Improving the efficiency of V\u03b39V\u03b42 T-cell immunotherapy in cancer","volume":"9","author":"Hoeres","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib156","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41573-019-0038-z","article-title":"Translating \u03b3\u03b4 (\u03b3\u03b4) T cells and their receptors into cancer cell therapies","volume":"19","author":"Sebestyen","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2020.11.023_bib157","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s00262-005-0094-6","article-title":"Characterization of the \u03b3\u03b4 T cell response to acute leukemia","volume":"55","author":"Meeh","year":"2006","journal-title":"Cancer Immunol Immunother"},{"issue":"30","key":"10.1016\/j.jaci.2020.11.023_bib158","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aav4036","article-title":"Generation and molecular recognition of melanoma-associated antigen-specific human \u03b3\u03b4 T cells","volume":"3","author":"Benveniste","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib159","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1158\/2326-6066.CIR-16-0348","article-title":"Squamous cell tumors recruit \u03b3\u03b4 T cells producing either IL17 or IFN\u03b3 depending on the tumor stage","volume":"5","author":"Lo Presti","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.jaci.2020.11.023_bib160","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/cei.13436","article-title":"Hypoxia regulates the differentiation and anti-tumor effector functions of \u03b3\u03b4T cells in oral cancer","volume":"201","author":"Sureshbabu","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib161","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4049\/jimmunol.1601455","article-title":"IL-23 inhibits melanoma development by augmenting DNA repair and modulating T cell subpopulations","volume":"198","author":"Nasti","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.023_bib162","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/713859","article-title":"Hmgb1-IL-23-IL-17-IL-6-Stat3 axis promotes tumor growth in murine models of melanoma","volume":"2013","author":"Tang","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jaci.2020.11.023_bib163","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/CMR.0000000000000151","article-title":"IL-17, IL-23, and p73 expression in cutaneous melanoma: a pilot study","volume":"25","author":"Ganzetti","year":"2015","journal-title":"Melanoma Res"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920316419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920316419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:28:58Z","timestamp":1758792538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674920316419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":163,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0091674920316419"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.023","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the complexity of \u03b3\u03b4 T-cell subsets in skin homeostasis, inflammation, and malignancy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}