{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:22:00Z","timestamp":1790403720309,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1 HL141493"],"award-info":[{"award-number":["RO1 HL141493"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_184757"],"award-info":[{"award-number":["310030_184757"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310039_185114"],"award-info":[{"award-number":["310039_185114"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_179165\/1"],"award-info":[{"award-number":["310030_179165\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jaci.2020.11.031","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T15:44:40Z","timestamp":1607528680000},"page":"1430-1441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model"],"prefix":"10.1016","volume":"147","author":[{"given":"Paul","family":"Engeroff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Plattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Storni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Thoms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayluz","family":"Frias Boligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Muerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Eggel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Gunten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.11.031_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri3632","article-title":"The production and regulation of IgE by the immune system","volume":"14","author":"Wu","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2072","article-title":"New developments in Fc\u03b5RI regulation, function and inhibition","volume":"7","author":"Kraft","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1146\/annurev.immunol.17.1.931","article-title":"The high-affinity IgE receptor (Fc\u03b5RI): from physiology to pathology","volume":"17","author":"Kinet","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nri2273","article-title":"IgE in allergy and asthma today","volume":"8","author":"Gould","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07204","article-title":"The development of allergic inflammation","volume":"454","author":"Galli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.11.031_bib6","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jaci.2016.04.007","article-title":"Role of IgE in autoimmunity","volume":"137","author":"Sanjuan","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib7","doi-asserted-by":"crossref","unstructured":"Abraham I, Alhossan A, Lee CS, Kutbi H, MacDonald K. \u201cReal-life\u201d effectiveness studies of omalizumab in adult patients with severe allergic asthma: systematic review. 2016;71:593-610.","DOI":"10.1111\/all.12815"},{"key":"10.1016\/j.jaci.2020.11.031_bib8","doi-asserted-by":"crossref","unstructured":"Lanier B, Bridges T, Kulus M, Taylor F, Berhane I. Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic ( IgE-mediated ) asthma. J Allergy Clin Immunol 124:1210-6.","DOI":"10.1016\/j.jaci.2009.09.021"},{"key":"10.1016\/j.jaci.2020.11.031_bib9","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1215372","article-title":"Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria","volume":"368","author":"Maurer","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.11.031_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jaci.2014.02.005","article-title":"Accelerated dissociation of IgE-Fc\u03b5RI complexes by disruptive inhibitors actively desensitizes allergic effector cells","volume":"133","author":"Eggel","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"7425","key":"10.1016\/j.jaci.2020.11.031_bib11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nature11546","article-title":"Accelerated disassembly of ige:receptor complexes by a disruptive macromolecular inhibitor","volume":"491","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.11.031_bib12","doi-asserted-by":"crossref","first-page":"11610","DOI":"10.1038\/ncomms11610","article-title":"Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange","volume":"7","author":"Pennington","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.11.031_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaci.2003.11.044","article-title":"Omalizumab rapidly decreases nasal allergic response and Fc\u03b5RI on basophils","volume":"113","author":"Lin","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.coi.2018.05.015","article-title":"Targeting IgE in allergic disease","volume":"54","author":"Gasser","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jaci.2016.04.056","article-title":"Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease","volume":"139","author":"Lawrence","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib16","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.4049\/jimmunol.134.5.3291","article-title":"Clearance of IgE from serum of normal and hybridoma-bearing mice","volume":"134","author":"Haba","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib17","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.4049\/jimmunol.1001900","article-title":"Murine B cells regulate serum IgE Levels in a CD23-dependent manner","volume":"185","author":"Cheng","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1172\/JCI68964","article-title":"Serum IgE clearance is facilitated by human Fc\u03b5RI internalization","volume":"124","author":"Greer","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.11.031_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/369753a0","article-title":"Negative feedback regulation of IgE synthesis by murine CD23","volume":"369","author":"Yu","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.11.031_bib20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/iid3.72","article-title":"High affinity targeting of CD23 inhibits IgE synthesis in human B cells","volume":"3","author":"Fellmann","year":"2015","journal-title":"Immunity Inflamm Dis"},{"key":"10.1016\/j.jaci.2020.11.031_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jaci.2017.09.024","article-title":"A novel recycling mechanism of native IgE-antigen complexes in human B cells facilitates transfer of antigen to dendritic cells for antigen presentation","volume":"142","author":"Engeroff","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib22","doi-asserted-by":"crossref","first-page":"28290","DOI":"10.1038\/srep28290","article-title":"IgE-mediated enhancement of CD4+ T cell responses requires antigen presentation by CD8\u03b1\u2212 conventional dendritic cells","volume":"6","author":"Ding","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.11.031_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jaci.2016.03.042","article-title":"CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells","volume":"139","author":"Selb","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0091-6749(05)80038-7","article-title":"Anti-IgE autoantibodies mistaken for specific IgG","volume":"89","author":"Jensen-Jarolim","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib25","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.jaci.2014.06.029","article-title":"\u201cAuto-anti-IgE\u201d: naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation","volume":"134","author":"Chan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000235413","article-title":"Elucidation of the epitope locations of human autoanti-IgE: recognition of two epitopes located within the C\u03b52 and the C\u03b54 domains","volume":"95","author":"Shakib","year":"1991","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-2222.1999.00441.x","article-title":"The anti-IgE\/anti-FcepsilonRIalpha autoantibody network in allergic and autoimmune diseases","volume":"29","author":"Marone","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.11.031_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jaci.2010.05.040","article-title":"Mechanisms of allergen-specific desensitization","volume":"126","author":"Uerm\u00f6si","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/all.13268","article-title":"Allergens displayed on virus-like particles are highly immunogenic but fail to activate human mast cells","volume":"73","author":"Engeroff","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.031_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jaci.2019.01.050","article-title":"Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects","volume":"144","author":"Thoms","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0165-2478(95)00014-V","article-title":"IgE-producing hybridomas established after B-cell culture in the CD40 system","volume":"46","author":"Z\u00fcrcher","year":"1995","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2020.11.031_bib32","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.4049\/jimmunol.157.4.1645","article-title":"Anaphylaxis mediated through a humanized high affinity IgE receptor","volume":"157","author":"Dombrowicz","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib33","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jaci.2017.09.054","article-title":"An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor Fc\u03b3RIIb","volume":"142","author":"Zha","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib34","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jaci.2019.12.007","article-title":"Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens","volume":"145","author":"Storni","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1398-9995.1995.tb05067.x","article-title":"Anti-IgE autoantibodies and bee-sting allergy","volume":"50","author":"Yu","year":"1995","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.031_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010524","article-title":"The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites","volume":"7","author":"Schneider","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2020.11.031_bib37","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/pr400714w","article-title":"Site-specific N-glycosylation analysis of human immunoglobulin E","volume":"13","author":"Plomp","year":"2014","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jaci.2020.11.031_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1084\/jem.20142182","article-title":"A single glycan on IgE is indispensable for initiation of anaphylaxis","volume":"212","author":"Shade","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.031_bib39","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.coi.2009.09.005","article-title":"Mouse models of allergic diseases","volume":"21","author":"Takeda","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib40","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1084\/jem.185.10.1785","article-title":"Role of repetitive antigen patterns for induction of antibodies against antibodies","volume":"185","author":"Fehr","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.11.031_bib41","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.4049\/jimmunol.173.11.6831","article-title":"The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin","volume":"173","author":"Arnold","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrd2804","article-title":"Glycosylation as a strategy to improve antibody-based therapeutics","volume":"8","author":"Jefferis","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2020.11.031_bib43","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000237017","article-title":"Role of glycosylation sites in the IgE Fc molecule","volume":"107","author":"Nettleton","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2020.11.031_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2311-z","article-title":"Sialylation of immunoglobulin E is a determinant of allergic pathogenicity","volume":"582","author":"Shade","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.11.031_bib45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaci.2019.07.045","article-title":"CD23 provides a noninflammatory pathway for IgE-allergen complexes","volume":"145","author":"Engeroff","year":"2020","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492031705X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167492031705X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:33:32Z","timestamp":1758792812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167492031705X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S009167492031705X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.031","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}