{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:33:57Z","timestamp":1790721237637,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jaci.2020.11.033","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T06:59:59Z","timestamp":1611039599000},"page":"984-991.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy"],"prefix":"10.1016","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-239X","authenticated-orcid":false,"given":"Corinne","family":"Keet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pistiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Plesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Szelag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Shreffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Dantzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkis","family":"Togias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.11.033_bib1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Du Toit","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.11.033_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaci.2016.10.010","article-title":"Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel","volume":"139","author":"Togias","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5694\/mja2.12102","article-title":"The Australasian Society of Clinical Immunology and Allergy infant feeding for allergy prevention guidelines","volume":"210","author":"Joshi","year":"2019","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaci.2020.11.033_bib4","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1111\/all.13846","article-title":"The health and economic benefits of approaches for peanut introduction in infants with a peanut allergic sibling","volume":"74","author":"Shaker","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib5","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jaci.2016.04.011","article-title":"Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy","volume":"138","author":"Koplin","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib6","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1111\/all.13446","article-title":"\u201cTo screen or not to screen\u201d: comparing the health and economic benefits of early peanut introduction strategies in five countries","volume":"73","author":"Shaker","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1542\/peds.2007-3022","article-title":"Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas","volume":"121","author":"Greer","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2020.11.033_bib8","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-0281","article-title":"The effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, hydrolyzed formulas, and timing of introduction of allergenic complementary foods","volume":"143","author":"Greer","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2020.11.033_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.anai.2016.11.014","article-title":"Guidelines for the prevention of peanut allergy in the United States: from development to prospective outcomes","volume":"118","author":"Assa\u2019ad","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1542\/peds.106.2.346","article-title":"Committee on Nutrition. Hypoallergenic infant formulas","volume":"106","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaci.2020.11.033_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1710-1492-4-4-144","article-title":"Should younger siblings of peanut-allergic children be assessed by an allergist before being fed peanut?","volume":"4","author":"Liem","year":"2008","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jaci.2013.11.019","article-title":"Population response to change in infant feeding guidelines for allergy prevention","volume":"133","author":"Tey","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib17","doi-asserted-by":"crossref","first-page":"Ab421","DOI":"10.1016\/j.jaci.2018.12.945","article-title":"Implementation of the 2017 Addendum Guidelines for Peanut Allergy Prevention Among AAAAI Allergists and Immunologists","volume":"143","author":"Johnson","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/cea.12403","article-title":"Peanut avoidance and peanut allergy diagnosis in siblings of peanut allergic children","volume":"45","author":"Lavine","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/bmj.313.7056.518","article-title":"Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges","volume":"313","author":"Hourihane","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jaci.2020.11.033_bib20","unstructured":"SCORAD. European Task Force on Atopic Dermatitis. Copyright Pr JF Stalder - ETFAD - 2014."},{"key":"10.1016\/j.jaci.2020.11.033_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000247298","article-title":"Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis","volume":"186","year":"1993","journal-title":"Dermatology"},{"key":"10.1016\/j.jaci.2020.11.033_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaci.2012.09.015","article-title":"Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study","volume":"131","author":"Du Toit","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cea.12406","article-title":"Which infants with eczema are at risk of food allergy? Results from a population-based cohort","volume":"45","author":"Martin","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib24","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0140-6736(16)31418-0","article-title":"Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial","volume":"389","author":"Natsume","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jaci.2020.11.033_bib25","doi-asserted-by":"crossref","unstructured":"Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson HT, et\u00a0al. Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented? [published online ahead of print April 6, 2020]. Allergy. https:\/\/doi.org\/10.1111\/all.14304.","DOI":"10.1111\/all.14304"},{"key":"10.1016\/j.jaci.2020.11.033_bib26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jaip.2017.03.013","article-title":"An Australian Consensus on Infant Feeding Guidelines to Prevent Food Allergy: Outcomes From the Australian Infant Feeding Summit","volume":"5","author":"Netting","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2020.11.033_bib27","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/cea.12090","article-title":"Optimal timing for solids introduction\u2014why are the guidelines always changing?","volume":"43","author":"Koplin","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/all.13127","article-title":"Letter of response to Greenhawt et\u00a0al. \u2018LEAPing Through the Looking Glass: Secondary Analysis of the Effect of Skin Test Size and Age of Introduction on Peanut Tolerance after Early Peanut Introduction\u2019","volume":"72","author":"Lawson","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib29","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/MPG.0000000000001454","article-title":"Complementary feeding: a position paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition: Erratum (vol 64, pg 119, 2017)","volume":"64","author":"Fewtrell","year":"2017","journal-title":"J Pediatr Gastr Nutr"},{"key":"10.1016\/j.jaci.2020.11.033_bib30","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1056\/NEJMoa1514210","article-title":"Randomized trial of introduction of allergenic foods in breast-fed infants","volume":"374","author":"Perkin","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.11.033_bib31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.anai.2018.03.001","article-title":"Caregiver and expecting caregiver support for early peanut introduction guidelines","volume":"120","author":"Greenhawt","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jaip.2019.12.008","article-title":"Real-life infant peanut allergy testing in the post-NIAID peanut guideline world","volume":"8","author":"Volertas","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2020.11.033_bib33","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.3390\/ijerph10115364","article-title":"The impact of family history of allergy on risk of food allergy: a population-based study of infants","volume":"10","author":"Koplin","year":"2013","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jaci.2020.11.033_bib34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jaci.2007.05.026","article-title":"The prevalence of food allergy: a meta-analysis","volume":"120","author":"Rona","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/ACI.0000000000000194","article-title":"The genetics of the skin barrier in eczema and other allergic disorders","volume":"15","author":"Marenholz","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib36","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/MOP.0b013e32833252dc","article-title":"Genetics of food allergy","volume":"21","author":"Hong","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jaci.2020.11.033_bib37","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.jaci.2019.02.016","article-title":"The MALT1 locus and peanut avoidance in the risk for peanut allergy","volume":"143","author":"Winters","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib38","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/all.12487","article-title":"Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents","volume":"69","author":"Koplin","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2020.11.033_bib39","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.jaci.2019.08.009","article-title":"Allergic diseases among Asian children in the United States","volume":"144","author":"Dunlop","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.anai.2015.04.021","article-title":"Effect of poverty, urbanization, and race\/ethnicity on perceived food allergy in the United States","volume":"115","author":"McGowan","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.anai.2013.12.007","article-title":"Temporal trends and racial\/ethnic disparity in self-reported pediatric food allergy in the United States","volume":"112","author":"Keet","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2020.11.033_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaci.2016.10.010","article-title":"Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel","volume":"139","author":"Togias","year":"2017","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920317097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920317097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:31:37Z","timestamp":1758792697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674920317097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0091674920317097"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.033","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.11.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}