{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:44:13Z","timestamp":1790397853622,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005736","name":"Universit\u00e9 Paris Diderot","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jaci.2020.12.622","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T03:00:42Z","timestamp":1608087642000},"page":"1478-1489.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Basophils and IgE contribute to mixed connective tissue disease development"],"prefix":"10.1016","volume":"147","author":[{"given":"Yasmine","family":"Lamri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamila","family":"Vibhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Pacreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Boedec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Saidoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Mailleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benhamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Papo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Daugas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Sacr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-5834","authenticated-orcid":false,"given":"Nicolas","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.12.622_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9343(72)90064-2","article-title":"Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)","volume":"52","author":"Sharp","year":"1972","journal-title":"Am J Med"},{"key":"10.1016\/j.jaci.2020.12.622_bib2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/acr.22872","article-title":"Epidemiology of mixed connective tissue disease, 1985-2014: a population-based study","volume":"68","author":"Ungprasert","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.jaci.2020.12.622_bib3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1191\/0961203306lu2283rr","article-title":"Mixed connective tissue disease","volume":"15","author":"Venables","year":"2006","journal-title":"Lupus"},{"key":"10.1016\/j.jaci.2020.12.622_bib4","series-title":"Mixed connective tissue disease","author":"Sapkota","year":"2020"},{"key":"10.1016\/j.jaci.2020.12.622_bib5","doi-asserted-by":"crossref","first-page":"R302","DOI":"10.1186\/ar1490","article-title":"Autoantibodies specific for apoptotic U1-70K are superior serological markers for mixed connective tissue disease","volume":"7","author":"Hof","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaci.2020.12.622_bib6","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.4049\/jimmunol.180.12.8444","article-title":"CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease","volume":"180","author":"Greidinger","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1440-1843.2003.00445.x","article-title":"Bronchoalveolar lavage fluid cells in mixed connective tissue disease","volume":"8","author":"Enomoto","year":"2003","journal-title":"Respirology"},{"key":"10.1016\/j.jaci.2020.12.622_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5114\/reum.2015.51509","article-title":"U1-RNP and TLR receptors in the pathogenesis of mixed connective tissue disease, part I: the U1-RNP complex and its biological significance in the pathogenesis of mixed connective tissue disease","volume":"53","author":"Paradowska-Gorycka","year":"2015","journal-title":"Reumatologia"},{"key":"10.1016\/j.jaci.2020.12.622_bib9","doi-asserted-by":"crossref","first-page":"709","DOI":"10.4049\/jimmunol.172.1.709","article-title":"A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen","volume":"172","author":"Greidinger","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1365-2249.2001.01669.x","article-title":"Endothelial cell-binding activity of anti-U1-ribonucleoprotein antibodies in patients with connective tissue diseases","volume":"126","author":"Okawa-Takatsuji","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/art.21566","article-title":"A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen","volume":"54","author":"Greidinger","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaci.2020.12.622_bib12","first-page":"247","article-title":"Advances in mechanisms of systemic lupus erythematosus","volume":"17","author":"Dema","year":"2014","journal-title":"Discovery Med"},{"key":"10.1016\/j.jaci.2020.12.622_bib13","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaci.2020.12.622_bib14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/annrheumdis-2019-215089","article-title":"2019 update of the EULAR recommendations for the management of systemic lupus erythematosus","volume":"78","author":"Fanouriakis","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2020.12.622_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jaci.2017.02.035","article-title":"Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy","volume":"141","author":"Hussain","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib16","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1073\/pnas.1813927115","article-title":"Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages","volume":"115","author":"Shibata","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.12.622_bib17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00281-016-0568-y","article-title":"Basophil-derived IL-4 plays versatile roles in immunity","volume":"38","author":"Yamanishi","year":"2016","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jaci.2020.12.622_bib18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nm.2159","article-title":"Basophils and the T helper 2 environment can promote the development of lupus nephritis","volume":"16","author":"Charles","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2020.12.622_bib19","doi-asserted-by":"crossref","first-page":"7969","DOI":"10.1038\/s41598-017-08516-7","article-title":"Basophils\u00a0contribute to pristane-induced lupus-like nephritis model","volume":"7","author":"Dema","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.12.622_bib20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41467-018-03129-8","article-title":"Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs","volume":"9","author":"Pellefigues","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.12.622_bib21","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20140066","article-title":"Immunoglobulin E plays an immunoregulatory role in lupus","volume":"211","author":"Dema","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2020.12.622_bib22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/art.40828","article-title":"Safety and tolerability of omalizumab: a randomized clinical trial of humanized anti-IgE monoclonal antibody in systemic lupus erythematosus","volume":"71","author":"Hasni","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jaci.2020.12.622_bib23","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1172\/JCI42680","article-title":"Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks","volume":"120","author":"Wada","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2020.12.622_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/370367a0","article-title":"Active anaphylaxis in IgE-deficient mice","volume":"370","author":"Oettgen","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.12.622_bib25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2741\/S364","article-title":"Experimental advances in understanding allergic airway inflammation","volume":"5","author":"Deppong","year":"2013","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.jaci.2020.12.622_bib26","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0002-9440(10)61235-7","article-title":"Role of eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis","volume":"167","author":"Huaux","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2020.12.622_bib27","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/cea.13157","article-title":"FcepsilonRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy","volume":"48","author":"Berings","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2020.12.622_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.imlet.2010.12.002","article-title":"Adjuvants determine the contribution of basophils to antigen sensitization in\u00a0vivo","volume":"136","author":"Ishida","year":"2011","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaci.2020.12.622_bib29","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/ncomms2740","article-title":"Basophils are required for the induction of Th2 immunity to haptens and peptide antigens","volume":"4","author":"Otsuka","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.12.622_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090424","article-title":"Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis","volume":"9","author":"Dema","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.12.622_bib31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ni.3326","article-title":"Self-reactive IgE exacerbates interferon responses associated with autoimmunity","volume":"17","author":"Henault","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fimmu.2017.00348","article-title":"Basophil activation-dependent autoantibody and interleukin-17 production exacerbate systemic lupus erythematosus","volume":"8","author":"Pan","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/eji.201747351","article-title":"Treatment of MCPT8(DTR) mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors","volume":"48","author":"El Hachem","year":"2018","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86131","article-title":"A cytotoxic anti-IL-3Ralpha antibody targets key cells and cytokines implicated in systemic lupus erythematosus","volume":"1","author":"Oon","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2020.12.622_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1097","article-title":"A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus","volume":"8","author":"Oon","year":"2019","journal-title":"Clin Transl Immunol"},{"key":"10.1016\/j.jaci.2020.12.622_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000438617","article-title":"IL-4 modulates CCL11 and CCL20 productions from IL-1beta-stimulated human periodontal ligament cells","volume":"38","author":"Hosokawa","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jaci.2020.12.622_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.anai.2019.08.014","article-title":"New treatments for chronic urticaria","volume":"124","author":"Kolkhir","year":"2020","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920324088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674920324088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:33:56Z","timestamp":1758792836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674920324088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0091674920324088"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.12.622","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basophils and IgE contribute to mixed connective tissue disease development","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.12.622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}