{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:25:27Z","timestamp":1783607127539,"version":"3.55.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander University Erlangen-Nuremberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1873"],"award-info":[{"award-number":["GRK1873"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2690"],"award-info":[{"award-number":["FOR2690"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AG 271\/1-1"],"award-info":[{"award-number":["AG 271\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STA 1159\/4-1"],"award-info":[{"award-number":["STA 1159\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR3618\/3-1"],"award-info":[{"award-number":["KR3618\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jaci.2020.12.655","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T22:58:57Z","timestamp":1613861937000},"page":"506-522.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7931-6056","authenticated-orcid":false,"given":"Katharina","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Glaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Agelopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ectors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Zahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne K.","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Thimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa E.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Kretschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita N.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathachit","family":"Limjunyawong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Kolkhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Scheffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia Lykke","family":"S\u00f8gaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Weigmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Hawro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.M.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas E.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2020.12.655_bib1","first-page":"501","article-title":"Drug hypersensitivity - diagnosis, genetics, and prevention","volume":"115","author":"B\u00f6hm","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jaci.2020.12.655_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000453265","article-title":"Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms","volume":"171","author":"Pichler","year":"2017","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18061223","article-title":"Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed patho-mechanism: IgE-mediated, pharmacological adverse reaction or \u201cinnate hypersensitivity\u201d?","volume":"18","author":"Spoerl","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaci.2020.12.655_bib4","first-page":"1","article-title":"Recent developments and highlights in drug hypersensitivity","author":"Mayorga","year":"2019","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000479878","article-title":"Drug-induced pseudoallergy: a review of the causes and mechanisms","volume":"101","author":"Zhang","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.jaci.2020.12.655_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri3690","article-title":"Mast cell secretory granules: armed for battle","volume":"14","author":"Wernersson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.it.2017.01.008","article-title":"Positive and negative signals in mast cell activation","volume":"38","author":"Bulfone-Paus","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib8","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jaci.2016.02.015","article-title":"Human IgE-independent systemic anaphylaxis","volume":"137","author":"Finkelman","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib9","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbrc.2006.08.177","article-title":"Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors","volume":"349","author":"Tatemoto","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2020.12.655_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/prp2.547","article-title":"MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions","volume":"7","author":"Grimes","year":"2019","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.jaci.2020.12.655_bib11","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jaci.2016.04.051","article-title":"Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases","volume":"138","author":"Subramanian","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib12","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.3389\/fimmu.2018.03027","article-title":"Mas-related G protein-coupled receptor-X2 (MRGPRX2) in drug hypersensitivity reactions","volume":"9","author":"Porebski","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(01)00483-4","article-title":"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons","volume":"106","author":"Dong","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2020.12.655_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nn815","article-title":"Proenkephalin A\u00a0gene products activate a new family of sensory neuron-specific GPCRs","volume":"5","author":"Lembo","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaci.2020.12.655_bib15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2020.12.655_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1476-5381.1951.tb00661.x","article-title":"Compound 48\/80: a potent histamine liberator","volume":"6","author":"PATON","year":"1951","journal-title":"Br J Pharmacol Chemother"},{"key":"10.1016\/j.jaci.2020.12.655_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2020.12.655_bib18","doi-asserted-by":"crossref","first-page":"23559","DOI":"10.1074\/jbc.M314240200","article-title":"Identification of a G protein-coupled receptor specifically responsive to \u03b2-alanine","volume":"279","author":"Shinohara","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2020.12.655_bib19","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1073\/pnas.1732949100","article-title":"Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family","volume":"100","author":"Zylka","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2020.12.655_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-genet-120116-024723","article-title":"Mas-related G protein-coupled receptors and the biology of itch sensation","volume":"51","author":"Meixiong","year":"2017","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.jaci.2020.12.655_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archderm.1984.01650370086015","article-title":"Chloroquine-induced pruritus among patients with malaria","volume":"120","author":"Osifo","year":"1984","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaci.2020.12.655_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2340\/00015555-0650","article-title":"Drug-induced pruritus: a review","volume":"89","author":"Reich","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2020.12.655_bib23","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMcp1208814","article-title":"Chronic pruritus","volume":"368","author":"Yosipovitch","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.12.655_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/brain\/awt158","article-title":"The neurology of itch","volume":"137","author":"Dhand","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.jaci.2020.12.655_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nn.3619","article-title":"Why we scratch an itch: the molecules, cells and circuits of itch","volume":"17","author":"Bautista","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaci.2020.12.655_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-083019-024537","article-title":"Neural mechanisms of itch","volume":"43","author":"Lay","year":"2020","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jaci.2020.12.655_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/07367228709144620","article-title":"the magnitude and duration of itch produced by intracutaneous injections of histamine","volume":"5","author":"Simone","year":"1987","journal-title":"Somatosens Res"},{"key":"10.1016\/j.jaci.2020.12.655_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2011.06.002","article-title":"Histamine H 1, H 3 and H 4 receptors are involved in pruritus","volume":"190","author":"Rossbach","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jaci.2020.12.655_bib29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2018.03.023","article-title":"Peripheral and central mechanisms of itch","volume":"98","author":"Dong","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2020.12.655_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2019.00299","article-title":"Heterogeneity of human mast cells with respect to MRGPRX2 receptor expression and function","volume":"13","author":"Varricchi","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jaci.2020.12.655_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0128951","article-title":"RNA-Seq analysis of human trigeminal and dorsal root ganglia with a focus on chemoreceptors","volume":"10","author":"Flegel","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.12.655_bib32","doi-asserted-by":"crossref","first-page":"44400","DOI":"10.1074\/jbc.M302456200","article-title":"MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion","volume":"278","author":"Robas","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2020.12.655_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molbrainres.2004.10.007","article-title":"Cloning and expression of MRG receptors in macaque, mouse, and human","volume":"133","author":"Zhang","year":"2005","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.jaci.2020.12.655_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jaci.2016.12.980","article-title":"Substance P activates Mas-related G protein-coupled receptors to induce itch","volume":"140","author":"Azimi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms8864","article-title":"Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs","volume":"6","author":"Reddy","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2020.12.655_bib36","article-title":"Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization","author":"Subramanian","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2020.12.655_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.1300023","article-title":"\u03b2-Defensins activate human mast cells via Mas-related gene X2","volume":"191","author":"Subramanian","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nchembio.2334","article-title":"In silico design of novel probes for the atypical opioid receptor MRGPRX2","volume":"13","author":"Lansu","year":"2017","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jaci.2020.12.655_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.molimm.2019.04.008","article-title":"Phenothiazine antipsychotics exhibit dual properties in pseudo-allergic reactions: activating MRGPRX2 and inhibiting the H 1 receptor","volume":"111","author":"Hou","year":"2019","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib40","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0196-9781(02)00090-6","article-title":"G protein-dependent activation of mast cell by peptides and basic secretagogues","volume":"23","author":"Ferry","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.jaci.2020.12.655_bib41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2020.08.027","article-title":"Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies","volume":"14","author":"K\u00fchn","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0145-2126(02)00343-0","article-title":"Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma\/leukemia; activation following aggregation of Fc\u03b5RI or Fc\u03b3RI","volume":"27","author":"Kirshenbaum","year":"2003","journal-title":"Leuk Res"},{"key":"10.1016\/j.jaci.2020.12.655_bib43","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jid.2020.06.030","article-title":"MRGPRX2 activation causes increased skin reactivity in chronic spontaneous urticaria patients","volume":"141","author":"Shtessel","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2020.12.655_bib44","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1271\/bbb.100745","article-title":"Long-term cultured human skin mast cells are suitable for pharmacological studies of anti-allergic drugs due to high responsiveness to FceRI cross-linking","volume":"75","author":"Guhl","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jaci.2020.12.655_bib45","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/glia.23585","article-title":"Lysophosphatidic acid activates satellite glia cells and Schwann cells","volume":"67","author":"Robering","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.jaci.2020.12.655_bib46","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1089\/104303403322167993","article-title":"Retroviral vectors for high-level transgene expression in T lymphocytes","volume":"14","author":"Engels","year":"2003","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jaci.2020.12.655_bib47","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3324\/haematol.13067","article-title":"Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application","volume":"93","author":"Griffioen","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.jaci.2020.12.655_bib48","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1126\/science.8211139","article-title":"Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment","volume":"262","author":"Lawrence","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jaci.2020.12.655_bib49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0165-0270(98)00051-X","article-title":"A technique for fast application of heated solutions of different composition to cultured neurones","volume":"82","author":"Dittert","year":"1998","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jaci.2020.12.655_bib50","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1053\/j.gastro.2010.05.009","article-title":"Lysophosphatidic acid is a potential mediator of cholestatic pruritus","volume":"139","author":"Kremer","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2020.12.655_bib51","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1097\/j.pain.0000000000000197","article-title":"Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice","volume":"156","author":"Obara","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.jaci.2020.12.655_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-59092-2","article-title":"Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling","volume":"10","author":"K\u00fchn","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaci.2020.12.655_bib53","first-page":"1","article-title":"Flare size but not intensity reflects histamine-induced itch","author":"Lehmann","year":"2020","journal-title":"skin pharmacol physiol"},{"key":"10.1016\/j.jaci.2020.12.655_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101717","article-title":"drawing area-proportional 3-Venn diagrams using ellipses","volume":"9","author":"Micallef","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2020.12.655_bib55","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.4049\/jimmunol.1801227","article-title":"Angiogenic host defense peptide AG-30\/5C and bradykinin B 2 receptor antagonist icatibant are G protein biased agonists for MRGPRX2 in mast cells","volume":"202","author":"Roy","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib56","author":"Roth"},{"key":"10.1016\/j.jaci.2020.12.655_bib57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1527-3458.2001.tb00189.x","article-title":"Paroxetine: a review","volume":"7","author":"Bourin","year":"2001","journal-title":"CNS Drug Rev"},{"key":"10.1016\/j.jaci.2020.12.655_bib58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2012.12.006","article-title":"Neurochemical profiles of some novel psychoactive substances","volume":"700","author":"Iversen","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-2999(97)01393-9","article-title":"Pharmacological profile of antidepressants and related compounds at human monoamine transporters","volume":"340","author":"Tatsumi","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib60","series-title":"Handbook of experimental pharmacology","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-7091-1368-4_9","article-title":"Functional inhibitors of acid sphingomyelinase (FIASMAs)","author":"Kornhuber","year":"2013"},{"key":"10.1016\/j.jaci.2020.12.655_bib61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ddr.430200305","article-title":"In\u00a0vivo binding properties of non-sedating antihistamines to CNS histamine receptors","volume":"20","author":"McQuade","year":"1990","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.jaci.2020.12.655_bib62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","article-title":"HL-Histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs","volume":"28","author":"Kroeze","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jaci.2020.12.655_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","article-title":"Mood disorders and schizophrenia","volume":"3","author":"Roth","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2020.12.655_bib64","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(01)01145-3","article-title":"Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine","volume":"50","author":"Owens","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jaci.2020.12.655_bib65","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0954-6111(06)80184-8","article-title":"The effect of a \u03b22-adrenergic agonist and a histamine H1-receptor antagonist on the late asthmatic response to inhaled antigen","volume":"85","author":"Eiser","year":"1991","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2020.12.655_bib66","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1476-5381.1992.tb12778.x","article-title":"Effect of histamine and histamine analogues on human isolated myometrial strips","volume":"107","author":"Mart\u00ednez-Mir","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(96)00402-5","article-title":"Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems","volume":"311","author":"Kobayashi","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib68","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/clpt.2011.177","article-title":"Linking pharmacology to clinical reports cyclobenzaprine and its possible association with serotonin syndrome","volume":"90","author":"Mestres","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jaci.2020.12.655_bib69","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fphys.2014.00331","article-title":"Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons","volume":"5","author":"Beckmann","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.jaci.2020.12.655_bib70","first-page":"1","article-title":"Measuring local anaphylaxis in mice","author":"Evans","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jaci.2020.12.655_bib71","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.toxicon.2018.09.002","article-title":"Conopeptides promote itch through human itch receptor hMgprX1","volume":"154","author":"Espino","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.jaci.2020.12.655_bib72","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/mol.111.071472","article-title":"PMX-53 as a dual CD88 antagonist and an agonist for mas-related gene 2 (MrgX2) in human mast cells","volume":"79","author":"Subramanian","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib73","first-page":"464","article-title":"Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs","volume":"56","author":"Tasaka","year":"1986","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaci.2020.12.655_bib74","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.4049\/jimmunol.145.12.4252","article-title":"Proliferative potential of murine peritoneal mast cells after degranulation induced by compound 48\/80, substance P, tetradecanoylphorbol acetate, or calcium ionophore A23187","volume":"145","author":"Jozaki","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib75","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaci.2018.05.031","article-title":"Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice","volume":"142","author":"Lee","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib76","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/1570159X12666140828221720","article-title":"Fluoxetine and all other SSRIs are 5-HT2B agonists - importance for their therapeutic effects","volume":"12","author":"Peng","year":"2014","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib77","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.4049\/jimmunol.177.9.6422","article-title":"5-Hydroxytryptamine induces mast cell adhesion and migration","volume":"177","author":"Kushnir-Sukhov","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib78","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1043-6618(03)00157-9","article-title":"The effects of paroxetine on rat isolated vas deferens","volume":"48","author":"Yaris","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jaci.2020.12.655_bib79","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/S0022-5347(05)64250-4","article-title":"Calcium channel blocking activity of thioridazine, clomipramine and fluoxetine in isolated rat vas deferens: a relative potency measurement study","volume":"168","author":"Mousavizadeh","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.jaci.2020.12.655_bib80","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00210-015-1093-6","article-title":"How do basic secretagogues activate mast cells?","volume":"388","author":"Seifert","year":"2015","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","article-title":"The role of mast cells in allergic inflammation","volume":"106","author":"Amin","year":"2012","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2020.12.655_bib82","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/imr.12622","article-title":"Mast cell-neural interactions contribute to pain and itch","volume":"282","author":"Gupta","year":"2018","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2020.12.655_bib83","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.bbadis.2014.02.007","article-title":"Receptors, cells and circuits involved in pruritus of systemic disorders","volume":"1842","author":"Kremer","year":"2014","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"10.1016\/j.jaci.2020.12.655_bib84","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89362","article-title":"Dual action of neurokinin-1 antagonists on Mas-related GPCRs","volume":"1","author":"Azimi","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2020.12.655_bib85","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/imr.12635","article-title":"Role of mast cells and basophils in pruritus","volume":"282","author":"Steinhoff","year":"2018","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2020.12.655_bib86","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jaci.2020.12.655_bib87","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.gene.2005.03.001","article-title":"Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception","volume":"352","author":"Yang","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.jaci.2020.12.655_bib88","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11920-001-0057-3","article-title":"Psychocutaneous disorders","volume":"3","author":"Folks","year":"2001","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.jaci.2020.12.655_bib89","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1468-3083.2003.00749.x","article-title":"Psychoactive drugs and skin","volume":"17","author":"Hautmann","year":"2003","journal-title":"J Eur Acad Dermatology Venereol"},{"key":"10.1016\/j.jaci.2020.12.655_bib90","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/00128071-200203050-00005","article-title":"Adverse cutaneous reactions to antidepressants","volume":"3","author":"Warnock","year":"2002","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaci.2020.12.655_bib91","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00228-012-1376-5","article-title":"Drug-induced anaphylaxis: a decade review of reporting to the Portuguese Pharmacovigilance Authority","volume":"69","author":"Ribeiro-Vaz","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib92","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2340\/00015555-1400","article-title":"European guideline on chronic pruritus: in cooperation with the European dermatology forum (EDF) and the European academy of dermatology and venereology (EADV)","volume":"92","author":"Weisshaar","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2020.12.655_bib93","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.euroneuro.2018.01.007","article-title":"Antidepressants as antipruritic agents: a review","volume":"28","author":"Kaur","year":"2018","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib94","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2340\/00015555-0553","article-title":"Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study","volume":"89","author":"St\u00e4nder","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaci.2020.12.655_bib95","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/09546634.2019.1623369","article-title":"Tricyclic antidepressants for the treatment of chronic pruritus","volume":"32","author":"Boozalis","year":"2021","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.jaci.2020.12.655_bib96","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jpainsymman.2003.05.004","article-title":"Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial","volume":"26","author":"Zylicz","year":"2003","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.jaci.2020.12.655_bib97","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0536.1998.tb05817.x","article-title":"Contact allergy to antihistamines is not common","volume":"39","author":"Goossens","year":"1998","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2020.12.655_bib98","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0536.1995.tb00494.x","article-title":"Allergic contact dermatitis from topical doxepin","volume":"33","author":"Greenberg","year":"1995","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2020.12.655_bib99","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.euroneuro.2018.10.010","article-title":"Cutaneous adverse drug reactions to psychotropic drugs and their risk factors - a case-control study","volume":"29","author":"Greil","year":"2019","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jaci.2020.12.655_bib100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0536.1993.tb03555.x","article-title":"Delayed hypersensitivity drug reactions diagnosed by patch testing","volume":"29","author":"Calkin","year":"1993","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaci.2020.12.655_bib101","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1056\/NEJMra033121","article-title":"Advances in H 1 -Antihistamines","volume":"351","author":"Simons","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.12.655_bib102","first-page":"317","article-title":"Urticaria caused by antihistamines: report of 5 cases","volume":"19","author":"Rodr\u00edguez Del R\u00edo","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaci.2020.12.655_bib103","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJMoa1710926","article-title":"Oral versus intravenous antibiotics for bone and joint infection","volume":"380","author":"Li","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2020.12.655_bib104","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1542\/hpeds.2015-0069","article-title":"Adverse events in pediatric patients receiving long-term oral and intravenous antibiotics","volume":"6","author":"Murphy","year":"2016","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jaci.2020.12.655_bib105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1213\/ANE.0000000000000776","article-title":"The incidence of perioperative hypersensitivity reactions: a single-center, prospective, cohort study","volume":"121","author":"Berroa","year":"2015","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jaci.2020.12.655_bib106","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaip.2014.11.005","article-title":"Antibiotics are an important identifiable cause of perioperative anaphylaxis in the United States","volume":"3","author":"Gonzalez-Estrada","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2020.12.655_bib107","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/pds.4726","article-title":"Drug-induced anaphylactic reactions in children: a retrospective analysis of 159 validated spontaneous reports","volume":"28","author":"Sachs","year":"2019","journal-title":"Pharmacoepidemiol Drug Saf"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921002293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921002293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:03:33Z","timestamp":1777475013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921002293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":107,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0091674921002293"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2020.12.655","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2020.12.655","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}