{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:40:07Z","timestamp":1785768007358,"version":"3.56.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100015098","name":"Seoul Metropolitan Government Seoul National University Boramae Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI17C1669"],"award-info":[{"award-number":["HI17C1669"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A4A2002903"],"award-info":[{"award-number":["2020R1A4A2002903"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jaci.2021.02.027","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T12:34:00Z","timestamp":1614688440000},"page":"461-472.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Bone morphogenetic protein-2 as a novel biomarker for refractory chronic rhinosinusitis with nasal polyps"],"prefix":"10.1016","volume":"148","author":[{"given":"Jin Youp","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suha","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Suk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Mi","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Khalmuratova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuju","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Kon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyeon","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Cheol","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Pyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-No","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Wan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Woo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-3072","authenticated-orcid":false,"given":"Dae Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"260","key":"10.1016\/j.jaci.2021.02.027_bib1","first-page":"1","article-title":"Summary health statistics for US adults: national health interview survey, 2012. Vital and health statistics. Series 10, Data from the National Health Survey 2014","author":"Blackwell","year":"2014","journal-title":"Vital Health Stat 10"},{"key":"10.1016\/j.jaci.2021.02.027_bib2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2013an underestimated disease. A\u00a0GA2LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.02.027_bib3","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.2500\/ajra.2011.25.3630","article-title":"Prevalence and risk factors of chronic rhinosinusitis in Korea","volume":"25","author":"Kim","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2021.02.027_bib4","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1007\/s00405-015-3817-0","article-title":"Osteitis and chronic rhinosinusitis: a review of the current literature","volume":"273","author":"Leung","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2021.02.027_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/00016489409124322","article-title":"The inflammatory response of the sinus and nasal mucosa during sinusitis: implications for research and therapy","volume":"114","author":"Norlander","year":"1994","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaci.2021.02.027_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/00016489209100791","article-title":"Experimental maxillary sinusitis induced by bacteroides fragilis a bacteriological and histological study in rabbits","volume":"112","author":"Westrin","year":"1992","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaci.2021.02.027_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1288\/00005537-199204000-00010","article-title":"Osteoblastic osteitis of the maxillary sinus","volume":"102","author":"Tovi","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2021.02.027_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1165\/ajrcmb.27.2.4779","article-title":"Activation of bone morphogenetic protein\/Smad signaling in bronchial epithelial cells during airway inflammation","volume":"27","author":"Rosendahl","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2021.02.027_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.21053\/ceo.2020.00416","article-title":"Crosstalk between mucosal inflammation and bone metabolism in chronic rhinosinusitis","volume":"14","author":"Khalmuratova","year":"2021","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2021.02.027_bib10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2500\/ajr.2006.20.2857","article-title":"The incidence of concurrent osteitis in patients with chronic rhinosinusitis: a clinicopathological study","volume":"20","author":"Lee","year":"2006","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaci.2021.02.027_bib11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/alr.20068","article-title":"The impact of osteitis on disease severity measures and quality of life outcomes in chronic rhinosinusitis","volume":"1","author":"Bhandarkar","year":"2011","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2021.02.027_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jb\/mvp148","article-title":"Bone morphogenetic protein receptors and signal transduction","volume":"147","author":"Miyazono","year":"2010","journal-title":"J Biochem"},{"key":"10.1016\/j.jaci.2021.02.027_bib13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0025-6196(11)60895-1","article-title":"Blood and sputum eosinophil levels in asthma and their relationship to sinus computed tomographic findings","author":"Mehta","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jaci.2021.02.027_bib14","first-page":"299","article-title":"Osteitic bone: a surrogate marker of eosinophilia in chronic rhinosinusitis","volume":"50","author":"Snidvongs","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2021.02.027_bib15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4168\/aair.2020.12.2.306","article-title":"Evaluation of neo-osteogenesis in eosinophilic chronic rhinosinusitis using a nasal polyp murine model","volume":"12","author":"Khalmuratova","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2021.02.027_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ebiom.2019.07.035","article-title":"Interleukin (IL)-13 and IL-17A contribute to neo-osteogenesis in chronic rhinosinusitis by inducing RUNX2","volume":"46","author":"Khalmuratova","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaci.2021.02.027_bib17","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1002\/lary.27581","article-title":"Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps","volume":"129","author":"Wu","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaci.2021.02.027_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","article-title":"Bone morphogenetic protein (BMP) signaling in development and human diseases","volume":"1","author":"Wang","year":"2014","journal-title":"Genes Dis"},{"key":"10.1016\/j.jaci.2021.02.027_bib19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1165\/rcmb.2014-0029OC","article-title":"Proprotein convertase 5\/6a is associated with bone morphogenetic protein-2-induced squamous cell differentiation","volume":"52","author":"Lee","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2021.02.027_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2021.02.027_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1749-4486.2010.02218.x","article-title":"Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery","volume":"35","author":"Georgalas","year":"2010","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.jaci.2021.02.027_bib22","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jaci.2016.09.026","article-title":"Cross-talk between human mast cells and epithelial cells by IgE-mediated periostin production in eosinophilic nasal polyps","volume":"139","author":"Kim","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4168\/aair.2020.12.1.42","article-title":"Elastase-positive neutrophils are associated with refractoriness of chronic rhinosinusitis with nasal polyps in an Asian population","volume":"12","author":"Kim","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2021.02.027_bib24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3349\/ymj.2019.60.6.578","article-title":"Revisiting the clinical scoring system for the prognosis of chronic rhinosinusitis with nasal polyps","volume":"60","author":"Kim","year":"2019","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.jaci.2021.02.027_bib25","doi-asserted-by":"crossref","first-page":"980","DOI":"10.4168\/aair.2020.12.6.980","article-title":"Enhanced type 2 immune reactions by increased IL-22\/IL-22Ra1 signaling in chronic rhinosinusitis with nasal polyps","volume":"12","author":"Kim","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2021.02.027_bib26","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41385-019-0149-1","article-title":"The IFN-gamma-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition","volume":"12","author":"Lee","year":"2019","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib27","first-page":"698","article-title":"Package \u2018FactoMineR\u2019","volume":"96","author":"Husson","year":"2016","journal-title":"An R package"},{"key":"10.1016\/j.jaci.2021.02.027_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1536867X0400400301","article-title":"Multiple imputation of missing values","volume":"4","author":"Royston","year":"2004","journal-title":"Stata J"},{"key":"10.1016\/j.jaci.2021.02.027_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ACI.0000000000000701","article-title":"Epithelial-to-mesenchymal transition in neutrophilic chronic rhinosinusitis","volume":"21","author":"Ryu","year":"2021","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib30","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1164\/rccm.201109-1706OC","article-title":"Hypoxia-inducible factor 1 mediates nasal polypogenesis by inducing epithelial-to-mesenchymal transition","volume":"185","author":"Shin","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2021.02.027_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jaci.2015.07.026","article-title":"Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition","volume":"137","author":"Lee","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib32","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jat.3573","article-title":"Nasal epithelial barrier disruption by particulate matter \u22642.5 \u03bcm via tight junction protein degradation","volume":"38","author":"Zhao","year":"2018","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.jaci.2021.02.027_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12931-017-0595-9","article-title":"Role of human rhinovirus in triggering human airway epithelial-mesenchymal transition","volume":"18","author":"Minor","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2021.02.027_bib34","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/thoraxjnl-2019-213916","article-title":"Effects of Wnt signaling on epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyp","volume":"75","author":"Bae","year":"2020","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2021.02.027_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00005-016-0409-7","article-title":"Epithelial-mesenchymal transition in chronic rhinosinusitis: differences revealed between epithelial cells from nasal polyps and inferior turbinates","volume":"65","author":"Konnecke","year":"2017","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.jaci.2021.02.027_bib36","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3390\/cells8101130","article-title":"The interactivity between TGFbeta and BMP signaling in organogenesis, fibrosis, and cancer","volume":"8","author":"Dituri","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jaci.2021.02.027_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000351895","article-title":"Cellular and molecular aspects of bone remodeling","volume":"18","author":"Xiao","year":"2016","journal-title":"Front Oral Biol"},{"key":"10.1016\/j.jaci.2021.02.027_bib38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.025","article-title":"Bone morphogenetic protein signaling in bone homeostasis","volume":"80","author":"S\u00e1nchez-Duffhues","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jaci.2021.02.027_bib39","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/jcb.25082","article-title":"Osteoporosis-associated alteration in the signalling status of BMP-2 in human MSCs under adipogenic conditions","volume":"116","author":"Donoso","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jaci.2021.02.027_bib40","article-title":"MBP-positive and CD11c-positive cells are associated with different phenotypes of Korean patients with non-asthmatic chronic rhinosinusitis","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2021.02.027_bib41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2004.09.034","article-title":"Increased TGF-\u03b22 in severe asthma with eosinophilia","volume":"115","author":"Balzar","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S8756-3282(01)00638-X","article-title":"Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2","volume":"30","author":"Champagne","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.jaci.2021.02.027_bib43","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2017.07.065","article-title":"Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: constitutive auto\/paracrine osteogenic signaling by BMP-2 in M1 macrophages","volume":"491","author":"Dube","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaci.2021.02.027_bib44","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02553-2017","article-title":"Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes","volume":"53","author":"Zuo","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2021.02.027_bib45","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.2353\/ajpath.2010.090048","article-title":"Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2","volume":"176","author":"Yan","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2021.02.027_bib46","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2021.02.027_bib47","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2353\/ajpath.2010.090459","article-title":"Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression","volume":"176","author":"Luo","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaci.2021.02.027_bib48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1465-9921-14-36","article-title":"Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium","volume":"14","author":"McCormack","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.jaci.2021.02.027_bib49","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb1870","article-title":"Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis","volume":"11","author":"Little","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jaci.2021.02.027_bib50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/08977199609003229","article-title":"Heterodimeric bone morphogenetic proteins show enhanced activity in\u00a0vitro and in\u00a0vivo","volume":"13","author":"Israel","year":"1996","journal-title":"Growth Factors"},{"key":"10.1016\/j.jaci.2021.02.027_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147897","article-title":"BMP-7 treatment increases M2 macrophage differentiation and reduces inflammation and plaque formation in Apo E-\/- Mice","volume":"11","author":"Singla","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2021.02.027_bib52","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1139\/y2012-102","article-title":"Bone morphogenetic protein 7 polarizes THP-1 cells into M2 macrophages","volume":"90","author":"Rocher","year":"2012","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jaci.2021.02.027_bib53","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/alr.22218","article-title":"Deficiency in interleukin-10 production by M2 macrophages in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"8","author":"Wang","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaci.2021.02.027_bib54","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jaci.2013.02.003","article-title":"Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps","volume":"132","author":"Takabayashi","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.027_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2021.02.027_bib56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4168\/aard.2015.3.1.47","article-title":"Comparison of skin prick test and serum specific IgE measured by ImmunoCAP system for various inhalant allergens","volume":"3","author":"Nam","year":"2015","journal-title":"Allergy Asthma Respir Dis"},{"key":"10.1016\/j.jaci.2021.02.027_bib57","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1749-4486.2010.02218.x","article-title":"Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery","volume":"35","author":"Georgalas","year":"2010","journal-title":"Clin Otolaryngol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921003511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921003511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:30:44Z","timestamp":1758792644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921003511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0091674921003511"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.02.027","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone morphogenetic protein-2 as a novel biomarker for refractory chronic rhinosinusitis with nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}