{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:19:39Z","timestamp":1793827179230,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["833247"],"award-info":[{"award-number":["833247"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["270218"],"award-info":[{"award-number":["270218"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jaci.2021.02.041","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T19:40:17Z","timestamp":1616182817000},"page":"1030-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients"],"prefix":"10.1016","volume":"148","author":[{"given":"Yessica A.","family":"Rodriguez-Rosales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen D.","family":"Langereis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.J.","family":"Gorris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juul M.P.A.","family":"van den Reek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Fasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Jolanda M.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Gomez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"van Cranenbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Sondermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke M.G.J.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.P.M.","family":"Koenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2021.02.041_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.clindermatol.2013.11.001","article-title":"Psoriasis as a systemic disease","volume":"32","author":"Grozdev","year":"2014","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaci.2021.02.041_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Di Meglio","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jaci.2021.02.041_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00403-011-1169-1","article-title":"Innate immunity in the pathogenesis of psoriasis","volume":"303","author":"Sweeney","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaci.2021.02.041_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/exd.12345","article-title":"Establishing the dynamics of neutrophil accumulation in\u00a0vivo by reflectance confocal microscopy","volume":"23","author":"Wolberink","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaci.2021.02.041_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/imr.12448","article-title":"Human neutrophils in the saga of cellular heterogeneity: insights and open questions","volume":"273","author":"Scapini","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaci.2021.02.041_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncprheum0291","article-title":"Granulocyte colony-stimulating factor and neutrophils\u2014forgotten mediators of inflammatory disease","volume":"2","author":"Eyles","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.jaci.2021.02.041_bib7","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1182\/blood-2012-05-433755","article-title":"The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice","volume":"121","author":"Niu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3389\/fimmu.2019.00346","article-title":"Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease","volume":"10","author":"Grieshaber-Bouyer","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1172\/JCI57990","article-title":"A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1","volume":"122","author":"Pillay","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2021.02.041_bib11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2013.04.040","article-title":"Rhythmic modulation of the hematopoietic niche through neutrophil clearance","volume":"153","author":"Casanova-Acebes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.02.041_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2016.04.016","article-title":"Circadian regulation of human peripheral neutrophils","volume":"57","author":"Ella","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jaci.2021.02.041_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.immuni.2019.01.002","article-title":"A neutrophil timer coordinates immune defense and vascular protection","volume":"50","author":"Adrover","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.02.041_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2147\/PTT.S190507","article-title":"Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris","volume":"9","author":"Strohbuecker","year":"2019","journal-title":"Psoriasis Targets Ther"},{"key":"10.1016\/j.jaci.2021.02.041_bib15","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.celrep.2016.10.053","article-title":"Differential effects of environmental and genetic factors on T and B cell immune traits","volume":"17","author":"Aguirre-Gamboa","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2021.02.041_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/SHK.0000000000001222","article-title":"Long-term effects of experimental human endotoxemia on immune cell function: similarities and differences with sepsis","volume":"51","author":"Rodriguez-Rosales","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.jaci.2021.02.041_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108387","article-title":"BCG vaccination induces long-term functional reprogramming of human neutrophils","volume":"33","author":"Moorlag","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2021.02.041_bib18","article-title":"Eight-color multiplex immunohistochemistry for simultaneous detection of multiple immune checkpoint molecules within the tumor microenvironment","volume":"12","author":"Gorris","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib19","author":"Johnson"},{"key":"10.1016\/j.jaci.2021.02.041_bib20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1182\/blood-2016-04-713206","article-title":"Mature CD10+ and immature CD10\u2212 neutrophils present in G-CSF-treated donors display opposite effects on T cells","volume":"129","author":"Marini","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.20008","article-title":"Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: reference patterns for age-related changes and disease-induced shifts","volume":"60B","author":"van Lochem","year":"2004","journal-title":"Cytometry"},{"key":"10.1016\/j.jaci.2021.02.041_bib22","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1182\/blood-2006-12-063826","article-title":"Neutrophils efficiently cross-prime naive T cells in\u00a0vivo","volume":"110","author":"Beauvillain","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib23","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.4049\/jimmunol.1103414","article-title":"T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses","volume":"188","author":"Tillack","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib24","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.jid.2018.11.021","article-title":"Neutrophil extracellular traps induce human Th17 cells: effect of psoriasis-associated TRAF3IP2 genotype","volume":"139","author":"Lambert","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2021.02.041_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/149560","article-title":"Deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma","volume":"2012","author":"Meng","year":"2012","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jaci.2021.02.041_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib27","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1182\/blood-2012-07-445189","article-title":"Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells","volume":"121","author":"Matsushima","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4049\/jimmunol.1100123","article-title":"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis","volume":"187","author":"Lin","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib30","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/gutjnl-2016-313535","article-title":"CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD","volume":"67","author":"Zhou","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jaci.2021.02.041_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaf8943","article-title":"Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients","volume":"1","author":"Condamine","year":"2016","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"Soehnlein","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib33","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways","volume":"159","author":"Nograles","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2021.02.041_bib34","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jaci.2019.01.017","article-title":"Modulation of inflammatory gene transcripts in psoriasis vulgaris: differences between ustekinumab and etanercept","volume":"143","author":"Brodmerkel","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jaci.2019.04.029","article-title":"IL-17A inhibition by secukinumab induces early clinical, histopathological, and molecular resolution of psoriasis","volume":"144","author":"Krueger","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib36","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.celrep.2014.12.039","article-title":"Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer","volume":"10","author":"Sagiv","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2021.02.041_bib37","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.4049\/jimmunol.0902199","article-title":"A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs","volume":"184","author":"Denny","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.02.041_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2021.02.041_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-019-13756-4","article-title":"Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis","volume":"11","author":"Herster","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.02.041_bib40","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1182\/blood-2012-01-401364","article-title":"Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37","volume":"120","author":"Chamilos","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.02.041_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1127494","article-title":"Cell-to-cell distances between tumor-infiltrating inflammatory cells have the potential to distinguish functionally active from suppressed inflammatory cells","volume":"5","author":"Nagl","year":"2016","journal-title":"Oncoimmunology"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921004188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921004188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:31:47Z","timestamp":1758792707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921004188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0091674921004188"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.02.041","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}