{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:20:19Z","timestamp":1793312419652,"version":"4.5.0"},"reference-count":184,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jaci.2021.03.015","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T07:21:53Z","timestamp":1620199313000},"page":"1531-1547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s"],"prefix":"10.1016","volume":"147","author":[{"given":"Kathleen R.","family":"Bartemes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-2936","authenticated-orcid":false,"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2021.03.015_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1221064","article-title":"New paradigms in type 2 immunity","volume":"337","author":"Pulendran","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jaci.2021.03.015_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic mechanisms in asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"Fallon","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in\u00a0vivo","volume":"15","author":"Fort","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib5","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib6","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib7","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2021.03.015_bib8","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/all.13340","article-title":"Emerging roles of innate lymphoid cells in inflammatory diseases: clinical implications","volume":"73","author":"Kortekaas Krohn","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib10","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jaci.2016.09.011","article-title":"Innate lymphoid cells in allergic and nonallergic inflammation","volume":"138","author":"Morita","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.immuni.2012.06.020","article-title":"The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells","volume":"37","author":"Hoyler","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2012.08.015","article-title":"The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells","volume":"37","author":"Mjosberg","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2131","article-title":"Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus","volume":"12","author":"Monticelli","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2500\/aap.2019.40.4217","article-title":"Role of innate lymphoid cells in allergic diseases","volume":"40","author":"Pasha","year":"2019","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaci.2021.03.015_bib15","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.it.2020.08.009","article-title":"Tissue-specific features of innate lymphoid cells","volume":"41","author":"Meininger","year":"2020","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor ROR gamma t in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cell.2017.07.027","article-title":"Regulatory innate lymphoid cells control innate intestinal inflammation","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib18","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.jaci.2018.12.1018","article-title":"Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid","volume":"143","author":"Morita","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib19","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/s41467-017-02023-z","article-title":"Alternative activation generates IL-10 producing type 2 innate lymphoid cells","volume":"8","author":"Seehus","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.03.015_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaci.2013.03.048","article-title":"Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production","volume":"132","author":"Doherty","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2011.09.041","article-title":"Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity","volume":"129","author":"Barlow","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib23","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.1102832","article-title":"IL-33-responsive lineage\u2212 CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs","volume":"188","author":"Bartemes","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/eji.201142018","article-title":"Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma","volume":"42","author":"Klein Wolterink","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib25","doi-asserted-by":"crossref","first-page":"13921","DOI":"10.1073\/pnas.1307321110","article-title":"Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice","volume":"110","author":"Imai","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2021.03.015_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005374","article-title":"TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation","volume":"5","author":"Kim","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib27","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jaci.2015.09.019","article-title":"IL-25 and CD4(+) T(H)2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy","volume":"137","author":"Lee","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib28","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2016.02.030","article-title":"IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function","volume":"138","author":"Noval Rivas","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib29","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.4049\/jimmunol.2000029","article-title":"Group 2 innate lymphoid cells promote development of T follicular helper cells and initiate allergic sensitization to peanuts","volume":"204","author":"Krempski","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib30","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jaci.2013.10.056","article-title":"Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells","volume":"133","author":"Xue","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jaci.2021.03.015_bib32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature23469","article-title":"Neuronal regulation of type 2 innate lymphoid cells via neuromedin U","volume":"549","author":"Cardoso","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature23676","article-title":"The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation","volume":"549","author":"Klose","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature24029","article-title":"The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation","volume":"549","author":"Wallrapp","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature14115","article-title":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity","volume":"519","author":"Brestoff","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2014.12.011","article-title":"Activated type 2 innate lymphoid cells regulate beige fat biogenesis","volume":"160","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"McHedlidze","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1073\/pnas.1315854111","article-title":"IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis","volume":"111","author":"Hams","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2021.03.015_bib39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.immuni.2020.03.002","article-title":"Bacteria-induced group 2 innate lymphoid cells in the stomach provide immune protection through induction of IgA","volume":"52","author":"Satoh-Takayama","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8546","article-title":"Pulmonary neuroendocrine cells amplify allergic asthma responses","volume":"360","author":"Sui","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jaci.2021.03.015_bib41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.immuni.2019.09.005","article-title":"Calcitonin gene-related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses","volume":"51","author":"Wallrapp","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib42","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.aan4829","article-title":"beta2-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses","volume":"359","author":"Moriyama","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jaci.2021.03.015_bib43","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41577-019-0176-x","article-title":"Regulation of immune responses by tuft cells","volume":"19","author":"Schneider","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.immuni.2018.06.016","article-title":"Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit","volume":"49","author":"Nadjsombati","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"von Moltke","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.03.015_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat9453","article-title":"The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation","volume":"3","author":"Bankova","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax7224","article-title":"Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2","volume":"5","author":"Ualiyeva","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib48","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jaci.2018.02.006","article-title":"Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology","volume":"141","author":"Samuchiwal","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib49","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.immuni.2015.07.005","article-title":"Transcription factor Bcl11b controls identity and function of mature type 2 innate lymphoid cells","volume":"43","author":"Califano","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib50","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1016\/j.celrep.2019.10.077","article-title":"IRF-7 is a critical regulator of type 2 innate lymphoid cells in allergic airway inflammation","volume":"29","author":"He","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2021.03.015_bib51","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jaci.2016.06.035","article-title":"MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation","volume":"139","author":"Johansson","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib52","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.3389\/fimmu.2018.02232","article-title":"MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity","volume":"9","author":"Knolle","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib53","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.4049\/jimmunol.1800852","article-title":"Cutting edge: core binding factor beta is required for group 2 innate lymphoid cell activation","volume":"202","author":"Shen","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41467-019-08365-0","article-title":"Runx\/Cbfbeta complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation","volume":"10","author":"Miyamoto","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.03.015_bib55","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3389\/fimmu.2020.01225","article-title":"Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy","volume":"11","author":"Luu","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib56","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.jaci.2018.02.032","article-title":"Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate","volume":"142","author":"Thio","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib57","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T\u00a0helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"Halim","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib58","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.4049\/jimmunol.1300974","article-title":"Type 2 innate lymphoid cells drive CD4+ Th2 cell responses","volume":"192","author":"Mirchandani","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib60","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20051135","article-title":"TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand","volume":"202","author":"Ito","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib61","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/all.12446","article-title":"Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice","volume":"69","author":"Drake","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib62","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.immuni.2018.05.003","article-title":"Tissue-restricted adaptive type 2 immunity is orchestrated by expression of the costimulatory molecule OX40L on group 2 innate lymphoid cells","volume":"48","author":"Halim","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib63","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1038\/s41467-020-17813-1","article-title":"PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity","volume":"11","author":"Helou","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.03.015_bib64","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jaci.2017.04.043","article-title":"Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivity","volume":"141","author":"Maazi","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib65","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jaci.2019.03.008","article-title":"Toll-like receptor 9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity","volume":"144","author":"Thio","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/imm.13040","article-title":"Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells","volume":"156","author":"Cao","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2021.03.015_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax7006","article-title":"Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation","volume":"4","author":"Patel","year":"2019","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2010-0031","article-title":"Sex differences and sex steroids in lung health and disease","volume":"33","author":"Townsend","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jaci.2021.03.015_bib69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4049\/jimmunol.1602085","article-title":"IL-33-responsive group 2 innate lymphoid cells are regulated by female sex hormones in the uterus","volume":"200","author":"Bartemes","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib70","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.celrep.2017.10.110","article-title":"Testosterone attenuates group 2 innate lymphoid cell-mediated airway inflammation","volume":"21","author":"Cephus","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jaci.2021.03.015_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214286","article-title":"Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production","volume":"14","author":"Matha","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jaci.2021.03.015_bib72","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ni.3078","article-title":"IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential \u2018inflammatory\u2019 type 2 innate lymphoid cells","volume":"16","author":"Huang","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib73","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coi.2018.11.001","article-title":"ILC2s\u2014resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?","volume":"56","author":"Germain","year":"2019","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib74","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1126\/science.aam5809","article-title":"S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense","volume":"359","author":"Huang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jaci.2021.03.015_bib75","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.immuni.2020.09.002","article-title":"In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors","volume":"53","author":"Zeis","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib76","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ni.3444","article-title":"IL-1beta, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs","volume":"17","author":"Bal","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib77","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ni.3447","article-title":"IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity","volume":"17","author":"Ohne","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib78","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ni.3443","article-title":"Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs","volume":"17","author":"Silver","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib79","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaci.2018.03.007","article-title":"IL-17-producing ST2(+) group 2 innate lymphoid cells play a pathogenic role in lung inflammation","volume":"143","author":"Cai","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib80","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.4049\/jimmunol.1601421","article-title":"Cutting edge: notch signaling promotes the plasticity of group-2 innate lymphoid cells","volume":"198","author":"Zhang","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib81","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.20151750","article-title":"IL-12 drives functional plasticity of human group 2 innate lymphoid cells","volume":"213","author":"Lim","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib82","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib83","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2016.04.029","article-title":"Developmental acquisition of regulomes underlies innate lymphoid cell functionality","volume":"165","author":"Shih","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib84","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41590-019-0423-0","article-title":"c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies","volume":"20","author":"Bernink","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib85","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/eji.201848006","article-title":"Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells","volume":"49","author":"Hochdorfer","year":"2019","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib86","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/eji.201242433","article-title":"STAT6-dependent and -independent mechanisms in Th2 polarization","volume":"42","author":"Maier","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib87","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1038\/s41467-019-09883-7","article-title":"IL-1beta, IL-23, and TGF-beta drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation","volume":"10","author":"Golebski","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.03.015_bib88","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/ni.2743","article-title":"Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1","volume":"14","author":"Spooner","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib89","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/gene.2014.83","article-title":"Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time","volume":"16","author":"Lim","year":"2015","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaci.2021.03.015_bib90","doi-asserted-by":"crossref","unstructured":"Howard E, Lewis G, Galle-Treger L, Hurrell BP, Helou DG, Shafiei-Jahani P, et\u00a0al. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivity [published online ahead of print September 6, 2020]. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2020.08.024.","DOI":"10.1016\/j.jaci.2020.08.024"},{"key":"10.1016\/j.jaci.2021.03.015_bib91","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.20021200","article-title":"The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression","volume":"198","author":"Komine","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib92","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ni1424","article-title":"Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells","volume":"8","author":"Djuretic","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib93","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41590-019-0399-9","article-title":"Adaptation and memory in immune responses","volume":"20","author":"Natoli","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib94","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.immuni.2016.06.017","article-title":"Allergen-experienced group 2 innate lymphoid cells acquire memory-like properties and enhance allergic lung inflammation","volume":"45","author":"Martinez-Gonzalez","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib95","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41590-018-0176-1","article-title":"Epigenetic control of innate and adaptive immune memory","volume":"19","author":"Lau","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib96","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib97","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.immuni.2016.11.005","article-title":"Human innate lymphoid cell subsets possess tissue-type based heterogeneity in phenotype and frequency","volume":"46","author":"Simoni","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib98","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2016.07.043","article-title":"The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome","volume":"166","author":"Gury-BenAri","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib99","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41590-018-0201-4","article-title":"Tissue signals imprint ILC2 identity with anticipatory function","volume":"19","author":"Ricardo-Gonzalez","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib100","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.jaci.2019.07.018","article-title":"Unconventional ST2- and CD127-negative lung ILC2 populations are induced by the fungal allergen Alternaria alternata","volume":"144","author":"Cavagnero","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib101","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.3389\/fimmu.2019.03114","article-title":"Pulmonary group 2 innate lymphoid cell phenotype is context specific: determining the effect of strain, location, and stimuli","volume":"10","author":"Entwistle","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib102","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.immuni.2019.04.019","article-title":"Tissue-resident group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming","volume":"50","author":"Schneider","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib103","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mjosberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib104","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/mi.2015.21","article-title":"The prostaglandin D(2) receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung","volume":"8","author":"Tait Wojno","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib105","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s13238-012-2927-3","article-title":"CCR10 and its ligands in regulation of epithelial immunity and diseases","volume":"3","author":"Xiong","year":"2012","journal-title":"Protein Cell"},{"key":"10.1016\/j.jaci.2021.03.015_bib106","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/all.13679","article-title":"CCR10(+) ILC2s with ILC1-like properties exhibit a protective function in severe allergic asthma","volume":"74","author":"Beuraud","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib107","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jaci.2020.01.038","article-title":"Optimal identification of human conventional and nonconventional (CRTH2(-)IL7Ralpha(-)) ILC2s using additional surface markers","volume":"146","author":"Liu","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib108","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2014.06.024","article-title":"Enhanced innate type 2 immune response in peripheral blood from patients with asthma","volume":"134","author":"Bartemes","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib109","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2014.11.037","article-title":"Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33","volume":"136","author":"Christianson","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib110","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1165\/rcmb.2016-0099OC","article-title":"IL-13(+) type 2 innate lymphoid cells correlate with asthma control status and treatment response","volume":"55","author":"Jia","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaci.2021.03.015_bib111","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.rmed.2015.09.016","article-title":"Type 2 innate lymphoid cells: a novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma","volume":"109","author":"Liu","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaci.2015.05.037","article-title":"Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia","volume":"137","author":"Smith","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib113","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000488050","article-title":"Increased group 2 innate lymphoid cells are correlated with eosinophilic granulocytes in patients with allergic airway inflammation","volume":"176","author":"Yu","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib114","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jaci.2015.06.038","article-title":"Type 2 innate lymphoid cells in induced sputum from children with severe asthma","volume":"137","author":"Nagakumar","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib115","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1164\/rccm.201612-2427OC","article-title":"Allergen-induced increases in sputum levels of group 2 innate lymphoid cells in subjects with asthma","volume":"196","author":"Chen","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib116","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jaci.2019.01.027","article-title":"Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients","volume":"144","author":"Winkler","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib117","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaci.2017.03.010","article-title":"beta2 integrins rather than beta1 integrins mediate Alternaria-induced group 2 innate\u00a0lymphoid cell trafficking to the lung","volume":"141","author":"Karta","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib118","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaci.2017.02.038","article-title":"Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients","volume":"141","author":"Sugita","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib119","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004812","article-title":"Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma","volume":"5","author":"Barnig","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib120","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.jaci.2018.10.069","article-title":"Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation","volume":"143","author":"Maric","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib121","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.jaci.2013.09.020","article-title":"Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis","volume":"133","author":"Chang","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib122","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.4049\/jimmunol.1601569","article-title":"Leukotriene C4 potentiates IL-33-induced group 2 innate lymphoid cell activation and lung inflammation","volume":"199","author":"Lund","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib123","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.20161274","article-title":"Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s","volume":"214","author":"von Moltke","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib124","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.jaci.2017.09.050","article-title":"Prostaglandin E2 suppresses human group 2 innate lymphoid cell function","volume":"141","author":"Maric","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib125","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fimmu.2018.00501","article-title":"Prostaglandin E2 inhibits group 2 innate lymphoid cell activation and allergic airway inflammation through E-prostanoid 4-cyclic adenosine monophosphate signaling","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib126","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4049\/jimmunol.1901544","article-title":"COX inhibition increases Alternaria-induced pulmonary group 2 innate lymphoid cell responses and IL-33 release in mice","volume":"205","author":"Zhou","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib127","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jaci.2016.01.050","article-title":"Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin","volume":"138","author":"Stier","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib128","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in\u00a0vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib129","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00109-019-01768-y","article-title":"Critical role of interleukin-23 in development of asthma promoted by cigarette smoke","volume":"97","author":"Lee","year":"2019","journal-title":"J Mol Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib130","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.jaci.2017.11.025","article-title":"Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses","volume":"142","author":"Cheon","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib131","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/all.13158","article-title":"Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium","volume":"72","author":"Uchida","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib132","doi-asserted-by":"crossref","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"Mortha","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jaci.2021.03.015_bib133","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.gastro.2017.09.006","article-title":"Intestinal dysbiosis featuring abundance of Ruminococcus gnavus associates with allergic diseases in infants","volume":"154","author":"Chua","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaci.2021.03.015_bib134","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/cea.13254","article-title":"Birch pollen-specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL-33 in mice","volume":"48","author":"van Rijt","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib135","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7024905","article-title":"Immunoregulatory effects of subcutaneous immunotherapy on lymphocyte subgroups and cytokines in children with asthma","volume":"2019","author":"He","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jaci.2021.03.015_bib136","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1111\/all.13438","article-title":"ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma","volume":"73","author":"Yu","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib137","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2017.03.032","article-title":"Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin","volume":"141","author":"Liu","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib138","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1038\/ncomms3675","article-title":"Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation","volume":"4","author":"Kabata","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaci.2021.03.015_bib139","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jaci.2017.10.020","article-title":"Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9(+) and IL-13(+) type 2 innate lymphoid cell subpopulations","volume":"142","author":"Verma","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib140","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.jaci.2017.11.043","article-title":"Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in\u00a0vivo","volume":"142","author":"Toki","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib141","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cellimm.2017.10.010","article-title":"Cyclosporin A\u00a0indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation","volume":"323","author":"Kudo","year":"2018","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib142","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/iid3.161","article-title":"Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps","volume":"5","author":"Poposki","year":"2017","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.jaci.2021.03.015_bib143","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/rccm.201212-2227OC","article-title":"IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps","volume":"188","author":"Shaw","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib144","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/all.12440","article-title":"Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis","volume":"69","author":"Miljkovic","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib145","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2021.03.015_bib146","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clim.2014.09.007","article-title":"Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness","volume":"155","author":"Walford","year":"2014","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2016.07.010","article-title":"Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis","volume":"170","author":"Tojima","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib148","doi-asserted-by":"crossref","unstructured":"Klingler AI, Stevens WW, Tan BK, Peters AT, Poposki JA, Grammer LC, et\u00a0al. Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps [published online ahead of print December 14, 2020]. J\u00a0Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2020.11.037.","DOI":"10.1016\/j.jaci.2020.11.037"},{"key":"10.1016\/j.jaci.2021.03.015_bib149","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00742-2018","article-title":"Innate lymphoid cells in the upper airways: importance of CD117 and IL-1RI expression","volume":"52","author":"Van Crombruggen","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2021.03.015_bib150","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.anai.2020.08.001","article-title":"Group 2 innate lymphoid cells in nasal polyposis","volume":"126","author":"Stevens","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib151","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41385-019-0215-8","article-title":"Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps","volume":"13","author":"Ogasawara","year":"2020","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib152","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1067\/mai.2003.67","article-title":"Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma","volume":"111","author":"Steinke","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib153","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jaci.2004.10.051","article-title":"Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis","volume":"115","author":"Corrigan","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib154","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaci.2016.11.023","article-title":"Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease","volume":"140","author":"Eastman","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib155","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jaci.2019.06.001","article-title":"Platelets attach to lung type 2 innate lymphoid cells (ILC2s) expressing P-selectin glycoprotein ligand 1 and influence ILC2 function","volume":"144","author":"Karta","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib156","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2011-10-384826","article-title":"Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes","volume":"119","author":"Laidlaw","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaci.2021.03.015_bib157","doi-asserted-by":"crossref","first-page":"16987","DOI":"10.1073\/pnas.1313185110","article-title":"Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes","volume":"110","author":"Liu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2021.03.015_bib158","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.1700603","article-title":"Type 2 cysteinyl leukotriene receptors drive IL-33-dependent type 2 immunopathology and aspirin sensitivity","volume":"200","author":"Liu","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib159","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2016.12.958","article-title":"Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines","volume":"140","author":"Salimi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib160","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jaci.2013.12.1086","article-title":"Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84","volume":"133","author":"Doherty","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib161","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jaci.2014.07.029","article-title":"Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy","volume":"134","author":"Lao-Araya","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib162","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jaci.2015.12.1325","article-title":"Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects","volume":"138","author":"Lombardi","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib163","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4168\/aair.2016.8.3.216","article-title":"Allergen-dependent differences in ILC2s frequencies in patients with allergic rhinitis","volume":"8","author":"Fan","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2021.03.015_bib164","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clim.2017.09.008","article-title":"Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis","volume":"183","author":"Zhong","year":"2017","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib165","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jaci.2019.11.029","article-title":"Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis","volume":"145","author":"Peng","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib166","doi-asserted-by":"crossref","unstructured":"Boonpiyathad T, Tantilipikorn P, Ruxrungtham K, Pradubpongsa P, Mitthamsiri W, Piedvache A, et\u00a0al. IL-10\u2013producing innate lymphoid cells increased in house-dust-mite allergic rhinitis patients following immunotherapy [published online ahead of print November 1, 2020]. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2020.10.029.","DOI":"10.1016\/j.jaci.2020.10.029"},{"key":"10.1016\/j.jaci.2021.03.015_bib167","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.immuni.2020.12.013","article-title":"Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response","volume":"54","author":"Golebski","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.03.015_bib168","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/ni.2584","article-title":"Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells","volume":"14","author":"Roediger","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib169","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.jid.2019.04.016","article-title":"IL-33-induced atopic dermatitis-like inflammation in mice is mediated by group 2 innate lymphoid cells in concert with basophils","volume":"139","author":"Imai","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2021.03.015_bib170","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2015.06.045","article-title":"Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity","volume":"137","author":"Saunders","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib171","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"Salimi","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib172","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jid.2016.07.017","article-title":"In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin","volume":"136","author":"Bruggen","year":"2016","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2021.03.015_bib173","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.jaci.2020.02.026","article-title":"ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation","volume":"145","author":"Leyva-Castillo","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib174","doi-asserted-by":"crossref","first-page":"E7572","DOI":"10.1073\/pnas.1606608113","article-title":"IL-33\/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy","volume":"113","author":"Liu","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2021.03.015_bib175","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.jid.2018.03.001","article-title":"Lack of type 2 innate lymphoid cells promotes a type I-driven enhanced immune response in contact hypersensitivity","volume":"138","author":"Rafei-Shamsabadi","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaci.2021.03.015_bib176","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2945","article-title":"Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis","author":"Chen","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib177","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao6923","article-title":"RORalpha-expressing T regulatory cells restrain allergic skin inflammation","volume":"3","author":"Malhotra","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib178","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2012.08.002","article-title":"IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization","volume":"131","author":"Chu","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib179","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131347","article-title":"Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy","volume":"4","author":"Chinthrajah","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaci.2021.03.015_bib180","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jaci.2015.05.048","article-title":"Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis","volume":"136","author":"Doherty","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.03.015_bib181","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nm.3281","article-title":"Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis","volume":"19","author":"Noti","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2021.03.015_bib182","doi-asserted-by":"crossref","first-page":"G13","DOI":"10.1152\/ajpgi.00290.2015","article-title":"Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice","volume":"310","author":"Judd","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jaci.2021.03.015_bib183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006373","article-title":"Compartment-specific distribution of human intestinal innate lymphoid cells is\u00a0altered in HIV patients under effective therapy","volume":"13","author":"Kramer","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaci.2021.03.015_bib184","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/all.12861","article-title":"IL-33 mediates reactive eosinophilopoiesis in response to airborne allergen exposure","volume":"71","author":"Anderson","year":"2016","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921004218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921004218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:31:46Z","timestamp":1758792706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921004218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":184,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0091674921004218"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.03.015","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}