{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:31:40Z","timestamp":1788348700476,"version":"build-2803163510"},"reference-count":10,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jaci.2021.06.027","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T23:21:44Z","timestamp":1625268104000},"page":"725-727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sensory neurons drive adaptive immunity in contact hypersensitivity"],"prefix":"10.1016","volume":"148","author":[{"given":"Knut","family":"Sch\u00e4kel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2021.06.027_bib1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2021.02.005","article-title":"Pituitary adenylate cyclase-activating polypeptide promotes cutaneous dendritic cell functions in contact hypersensitivity","volume":"148","author":"Yamamoto","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.06.027_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-immunol-101719-113805","article-title":"Immunosensation: neuroimmune cross talk in the skin","volume":"39","author":"Tamari","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaci.2021.06.027_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2133.2005.06330.x","article-title":"Unilateral remission of psoriasis following traumatic nerve palsy","volume":"152","author":"Joseph","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaci.2021.06.027_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.06.027_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2021.06.027_bib6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","article-title":"Cutaneous TRPV1(+) neurons trigger protective innate type 17 anticipatory immunity","volume":"178","author":"Cohen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.06.027_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.06.027_bib8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cell.2020.11.028","article-title":"Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential","volume":"184","author":"Huang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2021.06.027_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2567.2004.01786.x","article-title":"Nerve fibres are required to evoke a contact sensitivity response in mice","volume":"111","author":"Beresford","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.jaci.2021.06.027_bib10","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.cell.2021.03.002","article-title":"Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921010551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921010551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:32:10Z","timestamp":1758792730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921010551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0091674921010551"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.06.027","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensory neurons drive adaptive immunity in contact hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.02.005","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}