{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:47:24Z","timestamp":1789753644629,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jaci.2021.07.046","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:48:27Z","timestamp":1631702907000},"page":"1464-1472.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-1066","authenticated-orcid":false,"given":"Veronika","family":"Kanderova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Svobodova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Borna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fejtkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vendula","family":"Martinu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Paderova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Svaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmila","family":"Kralova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fronkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Klocperk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepanka","family":"Pruhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ae","family":"Lee-Kirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Hornofova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Koblizek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Zimmermannova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Parackova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sediva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kalina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ales","family":"Janda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kayserova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Dvorakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Macek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Pohunek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Poh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Brdicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Hrusak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2021.07.046_bib1","first-page":"2267","article-title":"Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells","volume":"7","author":"Quintrell","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2021.07.046_bib2","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1038\/sj.onc.1208081","article-title":"Structure and regulation of Src family kinases","volume":"23","author":"Boggon","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jaci.2021.07.046_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20020873","article-title":"Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response","volume":"196","author":"Ernst","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.07.046_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1378\/chest.07-3020","article-title":"The possible role of hematopoietic cell kinase in the pathophysiology of COPD","volume":"135","author":"Yanagisawa","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2021.07.046_bib5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00439-006-0253-7","article-title":"Association of Hck genetic polymorphisms with gene expression and COPD","volume":"120","author":"Zhang","year":"2007","journal-title":"Hum Genet"},{"key":"10.1016\/j.jaci.2021.07.046_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fchem.2019.00822","article-title":"Discovery of non-peptide small molecule allosteric modulators of the Src-family kinase, Hck","volume":"7","author":"Dorman","year":"2019","journal-title":"Front Chem"},{"key":"10.1016\/j.jaci.2021.07.046_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbadis.2016.11.013","article-title":"Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin\/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin\/PI3K pathway","volume":"1863","author":"Roversi","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jaci.2021.07.046_bib8","doi-asserted-by":"crossref","first-page":"15752","DOI":"10.18632\/oncotarget.4199","article-title":"Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells","volume":"6","author":"Poh","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jaci.2021.07.046_bib10","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/385602a0","article-title":"Crystal structure of the Src family tyrosine kinase Hck","volume":"385","author":"Sicheri","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.07.046_bib9","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.jaci.2016.07.015","article-title":"Efficacy of the Janus kinase 1\/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children","volume":"138","author":"Fr\u00e9mond","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib11","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1074\/jbc.275.4.2721","article-title":"Reciprocal regulation of Hck activity by phosphorylation of Tyr 527 and Tyr 416","volume":"275","author":"Porter","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2021.07.046_bib12","doi-asserted-by":"crossref","first-page":"40832","DOI":"10.1074\/jbc.M508782200","article-title":"Activation of the Src family kinase Hck without SH3-linker release","volume":"280","author":"Lerner","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2021.07.046_bib13","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1242\/jcs.112.22.4067","article-title":"Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck \/ Fgr deficient macrophages","volume":"112","author":"Suen","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jaci.2021.07.046_bib14","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/CIRCULATIONAHA.114.012316","article-title":"Hck\/Fgr kinase deficiency reduces plaque growth and stability by blunting monocyte recruitment and intraplaque motility","volume":"132","author":"Medina","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jaci.2021.07.046_bib15","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1016\/j.febslet.2006.06.099","article-title":"Selective recruitment of src family kinase Hck by leukocyte integrin \u03b1M\u03b22 but not \u03b1L\u03b22 or \u03b1X\u03b22","volume":"580","author":"Tang","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaci.2021.07.046_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.177.1.604","article-title":"The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating \u03b22 integrin affinity and valency in neutrophils, but are required for \u03b22 integrin-mediated outside-in signaling involved in sustained adhesion","volume":"177","author":"Giagulli","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.162.2.1120","article-title":"Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck","volume":"162","author":"M\u00f3csai","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib18","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.4049\/jimmunol.1402011","article-title":"The Src-family kinases Hck and Fgr regulate early lipopolysaccharide-induced myeloid cell recruitment into the lung and their ability to secrete chemokines","volume":"195","author":"Mazzi","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib19","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1172\/JCI114111","article-title":"Cooperative interactions of LFA-1 and Mac-1 with intracellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in\u00a0vitro","volume":"83","author":"Smith","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaci.2021.07.046_bib20","first-page":"1","article-title":"Effectiveness and safety of ruxolitinib for the treatment of refractory systemic idiopathic juvenile arthritis like associated with interstitial lung disease: a case report","author":"Bader-Meunier","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaci.2021.07.046_bib21","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41375-020-0891-0","article-title":"The Janus kinase 1\/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation","volume":"34","author":"La Ros\u00e9e","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.jaci.2021.07.046_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2019.01186","article-title":"Mechanisms underlying the anti-inflammatory and immunosuppressive activity of ruxolitinib","volume":"9","author":"Elli","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jaci.2021.07.046_bib23","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.jaci.2018.07.020","article-title":"Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations","volume":"142","author":"Forbes","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10875-019-00737-x","article-title":"Human inborn errors of immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee","volume":"40","author":"Tangye","year":"2020","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib25","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaci.2021.07.046_bib26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2021.07.046_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10875-019-00737-x","article-title":"Human inborn errors of immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee","volume":"40","author":"Tangye","year":"2020","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1074\/mcp.M115.054593","article-title":"High-resolution antibody array analysis of childhood acute leukemia cells","volume":"15","author":"Kanderova","year":"2016","journal-title":"Mol Cell Proteom"},{"key":"10.1016\/j.jaci.2021.07.046_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.stem.2007.10.002","article-title":"Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer","volume":"2","author":"Welm","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jaci.2021.07.046_bib30","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1128\/MCB.25.12.4924-4933.2005","article-title":"Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases","volume":"25","author":"Brdicka","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaci.2021.07.046_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20020873","article-title":"Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response","volume":"196","author":"Ernst","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2021.07.046_bib32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ccell.2017.03.006","article-title":"Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression","volume":"31","author":"Poh","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jaci.2021.07.046_bib33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10875-018-0519-6","article-title":"Utility of ruxolitinib in a child with chronic mucocutaneous candidiasis caused by a novel STAT1 gain-of-function mutation","volume":"38","author":"Bloomfield","year":"2018","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaci.2021.07.046_bib34","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.exphem.2010.03.018","article-title":"Aberrantly expressed CEACAM6 is involved in the signaling leading to apoptosis of acute lymphoblastic leukemia cells","volume":"38","author":"Kanderova","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jaci.2021.07.046_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10071","article-title":"Activation of the innate immune receptor Dectin-1 upon formation of a \u201cphagocytic synapse\u201d","volume":"472","author":"Goodridge","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921013956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921013956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:34:53Z","timestamp":1758792893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921013956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0091674921013956"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.07.046","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.07.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}