{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:07:26Z","timestamp":1783530446954,"version":"3.55.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jaci.2021.11.003","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T03:00:04Z","timestamp":1637118004000},"page":"538-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune checkpoint skewing might be the cause of continuous immune activation in nasal polyps: New opportunities for therapies"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-1362","authenticated-orcid":false,"given":"Alex","family":"KleinJan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2021.11.003_bib1","first-page":"I","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2021.11.003_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2021.06.023","article-title":"Extrafollicular PD-1(high)CXCR5(-)CD4(+) T cells participate in local immunoglobulin production in nasal polyps","volume":"149","author":"Wang","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2021.11.003_bib3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.it.2017.10.003","article-title":"PD-1(hi)CXCR5(-)CD4(+) T-FH cells play defense in cancer and offense in arthritis","volume":"38","author":"Gu-Trantien","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaci.2021.11.003_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-020-2424-4","article-title":"Structural cells are key regulators of organ-specific immune responses","volume":"583","author":"Krausgruber","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2021.11.003_bib5","doi-asserted-by":"crossref","first-page":"18635","DOI":"10.1038\/s41598-020-75815-x","article-title":"Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case\u2013control study","volume":"10","author":"Shih","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.jaci.2021.11.003_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/s41375-020-01105-0","article-title":"Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression","volume":"35","author":"Sasi","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.jaci.2021.11.003_bib7","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.3389\/fimmu.2019.01790","article-title":"Overexpression of PDE4A acts as checkpoint inhibitor against cAMP-mediated immunosuppression in\u00a0vitro","volume":"10","author":"Schmetterer","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.11.003_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051329","article-title":"Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+\/CD54+ NK cells","volume":"22","author":"Chen","year":"2021","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jaci.2021.11.003_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.581673","article-title":"Apremilast regulates the Teff\/Treg balance to ameliorate uveitis via PI3K\/AKT\/FoxO1 signaling pathway","volume":"11","author":"Chen","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2021.11.003_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921017590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674921017590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:34:24Z","timestamp":1758792864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674921017590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0091674921017590"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2021.11.003","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune checkpoint skewing might be the cause of continuous immune activation in nasal polyps: New opportunities for therapies","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2021.06.023","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}