{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:34:56Z","timestamp":1793255696293,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970859"],"award-info":[{"award-number":["81970859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071020"],"award-info":[{"award-number":["82071020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171114"],"award-info":[{"award-number":["82171114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011093"],"award-info":[{"award-number":["2019A1515011093"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202002030034"],"award-info":[{"award-number":["202002030034"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jaci.2022.02.031","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T20:45:44Z","timestamp":1648241144000},"page":"337-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP"],"prefix":"10.1016","volume":"150","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Qiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Tian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou-Zhou","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.02.031_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2022.02.031_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2020.01.020","article-title":"Biologics for chronic rhinosinusitis with nasal polyps","volume":"145","author":"Bachert","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaci.2022.02.031_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4168\/aair.2020.12.3.507","article-title":"Role of IL-17A in chronic rhinosinusitis with nasal polyp","volume":"12","author":"Ryu","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2022.02.031_bib5","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1084\/jem.20181892","article-title":"Cell death-mediated cytokine release and its therapeutic implications","volume":"216","author":"Place","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaci.2022.02.031_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/intimm\/dxx018","article-title":"Mechanisms governing inflammasome activation, assembly and pyroptosis induction","volume":"29","author":"Kesavardhana","year":"2017","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174166","article-title":"Role of pyroptosis in diabetic retinopathy and its therapeutic implications","volume":"904","author":"Al Mamun","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaci.2022.02.031_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.02.031_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.02.031_bib10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature15632","article-title":"Immunology: caspase target drives pyroptosis","volume":"526","author":"Broz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.02.031_bib11","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaci.2022.02.031_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jaci.2022.02.031_bib13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jaci.2019.05.006","article-title":"NOD-like receptor family, pyrin domain containing 3 (NLRP3) contributes to inflammation, pyroptosis, and mucin production in human airway epithelium on rhinovirus infection","volume":"144","author":"Liu","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib14","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jaci.2020.01.009","article-title":"Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP)","volume":"145","author":"Wei","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib15","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s10753-016-0442-z","article-title":"Role of NLRP3 inflammasome in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps","volume":"39","author":"Lin","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.jaci.2022.02.031_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaci.2022.02.031_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/369312","article-title":"Responses of multipotent retinal stem cells to IL-1beta, IL-18, or IL-17","volume":"2015","author":"Chen","year":"2015","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.jaci.2022.02.031_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107781","article-title":"Interleukin-17 induces pyroptosis in osteoblasts through the NLRP3 inflammasome pathway in\u00a0vitro","volume":"96","author":"Lei","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaci.2022.02.031_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm.3423","article-title":"Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity","volume":"20","author":"Kim","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jaci.2022.02.031_bib20","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3389\/fimmu.2018.02121","article-title":"Tc17\/IL-17A up-regulated the expression of MMP-9 via NF-\u03baB pathway in nasal epithelial cells of patients with chronic rhinosinusitis","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib21","article-title":"IL-19 induced by IL-13\/IL-17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP-9 expression via ERK\/NF-\u03baB signaling pathway","volume":"11","author":"Li","year":"2021","journal-title":"Clin Translat Allergy"},{"key":"10.1016\/j.jaci.2022.02.031_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000507865","article-title":"Interleukin-17A expression correlated with the prognosis of chronic rhinosinusitis with nasal polyps and the anti-interleukin-17a effect in a murine nasal polyps model","volume":"82","author":"Huang","year":"2020","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.jaci.2022.02.031_bib23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/all.12840","article-title":"BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis","volume":"71","author":"Banuelos","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.02.031_bib24","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1158\/1078-0432.CCR-18-1478","article-title":"Molecular targeted therapies elicit concurrent apoptotic and GSDME-dependent pyroptotic tumor cell death","volume":"24","author":"Lu","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jaci.2022.02.031_bib25","doi-asserted-by":"crossref","first-page":"23869","DOI":"10.1073\/pnas.2007773117","article-title":"Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target","volume":"117","author":"He","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaci.2022.02.031_bib26","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jaci.2015.07.025","article-title":"Nasal IL-4(+)CXCR5(+)CD4(+) T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps","volume":"137","author":"Zhang","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib27","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jaci.2017.10.014","article-title":"Ectopic lymphoid tissues support local immunoglobulin production in patients with chronic rhinosinusitis with nasal polyps","volume":"141","author":"Song","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4168\/aair.2020.12.2.274","article-title":"Evidence for the presence of long-lived plasma cells in nasal polyps","volume":"12","author":"Zhang","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2022.02.031_bib29","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jaci.2022.02.031_bib30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/humu.20740","article-title":"A novel mutation in NFKBIA\/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency","volume":"29","author":"Lopez-Granados","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jaci.2022.02.031_bib31","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.jaci.2022.02.031_bib32","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1136\/thoraxjnl-2014-206736","article-title":"Inflammasomes in COPD and neutrophilic asthma","volume":"70","author":"Kim","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jaci.2022.02.031_bib33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3342\/kjorl-hns.2019.00738","article-title":"Nucleotide-binding oligomerization domain-like receptor 3 inflammasome inhibition by MCC950 reduces the lipopolysaccharide-induced interleukin-1\u03b2 in cultured dispersed nasal polyp cells","volume":"63","author":"Park","year":"2020","journal-title":"Korean Journal of Otorhinolaryngology-Head and Neck Surgery"},{"key":"10.1016\/j.jaci.2022.02.031_bib34","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.2147\/JIR.S322875","article-title":"Necroptosis underlies neutrophilic inflammation associated with the chronic rhinosinusitis with nasal polyps (CRSwNP)","volume":"14","author":"Xie","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jaci.2022.02.031_bib35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2500\/ajra.2015.29.4185","article-title":"The expression of 11\u03b2-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp","volume":"29","author":"Kook","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaci.2022.02.031_bib36","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/all.12667","article-title":"Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"70","author":"Liao","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.02.031_bib37","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1096\/fj.06-7859rev","article-title":"Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival","volume":"22","author":"Junttila","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.jaci.2022.02.031_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1517\/14728222.2011.645805","article-title":"Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy","volume":"16","author":"Santarpia","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jaci.2022.02.031_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1158\/2159-8290.CD-18-1321","article-title":"Targeting alterations in the RAF-MEK pathway","volume":"9","author":"Yaeger","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jaci.2022.02.031_bib40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.seminoncol.2015.09.023","article-title":"MEK1\/2 inhibitors: molecular activity and resistance mechanisms","volume":"42","author":"Wu","year":"2015","journal-title":"Semin Oncol"},{"key":"10.1016\/j.jaci.2022.02.031_bib41","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00405-012-2295-x","article-title":"Interleukin-17A contributes to the expression of serum amyloid A\u00a0in chronic rhinosinusitis with nasal polyps","volume":"270","author":"Wang","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jaci.2022.02.031_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154854","article-title":"6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis","volume":"125","author":"Zhang","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.jaci.2022.02.031_bib43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ng.3283","article-title":"NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells","volume":"47","author":"Paugh","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaci.2022.02.031_bib44","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3389\/fimmu.2020.01724","article-title":"Contribution of IL-17 in steroid hyporesponsiveness in obese asthmatics through dysregulation of glucocorticoid receptors alpha and beta","volume":"11","author":"Al Heialy","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib45","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1365-2222.2010.03544.x","article-title":"Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines","volume":"40","author":"Vazquez-Tello","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.02.031_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1164\/rccm.200507-1046OC","article-title":"Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma","volume":"173","author":"Goleva","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaci.2022.02.031_bib47","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.jaci.2004.03.018","article-title":"Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients","volume":"113","author":"Matthews","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib48","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.jaci.2013.12.004","article-title":"Anti-inflammatory and corticosteroid-enhancing actions of vitamin D in monocytes of patients with steroid-resistant and those\u00a0with steroid-sensitive asthma","volume":"133","author":"Zhang","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2017.03.032","article-title":"Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin","volume":"141","author":"Liu","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.02.031_bib50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jcf.2011.11.007","article-title":"IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis","volume":"11","author":"Derycke","year":"2012","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jaci.2022.02.031_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000232566","article-title":"Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis with nasal polyps associated with asthma","volume":"151","author":"Saitoh","year":"2010","journal-title":"Int Arch Allergy Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922003827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922003827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:36:29Z","timestamp":1758792989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674922003827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0091674922003827"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.02.031","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.02.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}