{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:13:03Z","timestamp":1793326383416,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630024"],"award-info":[{"award-number":["81630024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130030"],"award-info":[{"award-number":["82130030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108011"],"award-info":[{"award-number":["81920108011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jaci.2022.04.006","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T18:31:04Z","timestamp":1650479464000},"page":"727-735.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Untargeted metabolomic profiling identifies disease-specific and outcome-related signatures in chronic rhinosinusitis"],"prefix":"10.1016","volume":"150","author":[{"given":"Jing-Xian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Ting","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Zhang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-6702","authenticated-orcid":false,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaci.2022.04.006_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps, 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2022.04.006_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jaci.2009.05.017","article-title":"Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese","volume":"124","author":"Cao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.04.006_bib3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaci.2022.04.006_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nbt.4101","article-title":"Metabolomics activity screening for identifying metabolites that modulate phenotype","volume":"36","author":"Guijas","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jaci.2022.04.006_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chest.2016.10.008","article-title":"Asthma metabolomics and the potential for integrative omics in research and the clinic","volume":"151","author":"Kelly","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jaci.2022.04.006_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1365-2222.2006.02528.x","article-title":"Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis","volume":"36","author":"Okano","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.04.006_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.prostaglandins.2004.11.003","article-title":"Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes","volume":"75","author":"Gazi","year":"2005","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jaci.2022.04.006_bib8","doi-asserted-by":"crossref","first-page":"4394695","DOI":"10.1155\/2016\/4394695","article-title":"Effects of glutamate and aspartate on serum antioxidative enzyme, sex hormones, and genital inflammation in boars challenged with hydrogen peroxide","volume":"2016","author":"Ni","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jaci.2022.04.006_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jn\/nxaa006","article-title":"Leucine supplementation increases muscle strength and volume, reduces inflammation, and affects wellbeing in adults and adolescents with cerebral palsy","volume":"151","author":"Theis","year":"2021","journal-title":"J Nutr"},{"key":"10.1016\/j.jaci.2022.04.006_bib10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/ATVBAHA.119.313224","article-title":"Soluble uric acid promotes atherosclerosis via AMPK (AMP-activated protein kinase)-mediated inflammation","volume":"40","author":"Kimura","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jaci.2022.04.006_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4168\/aair.2019.11.6.806","article-title":"The role of NF-kappaB in chronic rhinosinusitis with nasal polyps","volume":"11","author":"Jung","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaci.2022.04.006_bib12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0026-895X(25)11415-6","article-title":"Cation and structural requirements for P site\u2013mediated inhibition of adenylate cyclase","volume":"35","author":"Johnson","year":"1989","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jaci.2022.04.006_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/path.2716","article-title":"Implication of adenylyl cyclase 8 in pathological smooth muscle cell migration occurring in rat and human vascular remodelling","volume":"221","author":"Gueguen","year":"2010","journal-title":"J Pathol"},{"key":"10.1016\/j.jaci.2022.04.006_bib14","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3389\/fimmu.2020.00748","article-title":"Specific polyunsaturated fatty acids can modulate in\u00a0vitro human moDC2s and subsequent Th2 cytokine release","volume":"11","author":"Hoppenbrouwers","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaci.2022.04.006_bib15","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/molecules24050852","article-title":"The ethanol extract of Holotrichia diomphalia larvae, containing fatty acids and amino acids, exerts anti-asthmatic effects through inhibition of the GATA-3\/Th2 signaling pathway in asthmatic mice","volume":"24","author":"Hong","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jaci.2022.04.006_bib16","doi-asserted-by":"crossref","first-page":"9171905","DOI":"10.1155\/2018\/9171905","article-title":"Functions and signaling pathways of amino acids in intestinal inflammation","volume":"2018","author":"He","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jaci.2022.04.006_bib17","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.3390\/ijerph17134758","article-title":"Alterations in serum-free amino acid profiles in childhood asthma","volume":"17","author":"Matysiak","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jaci.2022.04.006_bib18","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2006.06.001","article-title":"The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells","volume":"1761","author":"Fruhwirth","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaci.2022.04.006_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/nu11020295","article-title":"Immunomodulatory effects of glutathione, garlic derivatives, and hydrogen sulfide","volume":"11","author":"Rodrigues","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jaci.2022.04.006_bib20","doi-asserted-by":"crossref","first-page":"25305","DOI":"10.1074\/jbc.M500095200","article-title":"Glutathione redox state regulates\u00a0mitochondrial reactive oxygen production","volume":"280","author":"Shen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaci.2022.04.006_bib21","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/all.14049","article-title":"A panel of clinical and biological markers predict difficult-to-treat chronic rhinosinusitis","volume":"75","author":"Liao","year":"2020","journal-title":"Allergy"},{"issue":"suppl\u00a01","key":"10.1016\/j.jaci.2022.04.006_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2222.2000.00092.x","article-title":"The role of eosinophils and neutrophils in inflammation","volume":"30","author":"Sampson","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaci.2022.04.006_bib23","doi-asserted-by":"crossref","first-page":"793073","DOI":"10.3389\/fcell.2021.793073","article-title":"Characterizing the neutrophilic inflammation in chronic rhinosinusitis with nasal polyps","volume":"9","author":"Ruan","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jaci.2022.04.006_bib24","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","article-title":"The activation and function of IL-36gamma in neutrophilic inflammation in chronic rhinosinusitis","volume":"141","author":"Wang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.04.006_bib25","first-page":"535","article-title":"Interleukin-8 expression in human nasal polyps","volume":"117","author":"Allen","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaci.2022.04.006_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps, 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaci.2022.04.006_bib27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jaci.2009.05.017","article-title":"Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese","volume":"124","author":"Cao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaci.2022.04.006_bib28","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/all.12963","article-title":"Allergic Rhinitis Control Test questionnaire\u2013driven stepwise strategy to improve allergic rhinitis control: a prospective study","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.04.006_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaci.2022.04.006_bib30","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/all.13411","article-title":"Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes","volume":"73","author":"Liao","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaci.2022.04.006_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nprot.2012.135","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nat Protoc"},{"issue":"13.24","key":"10.1016\/j.jaci.2022.04.006_bib32","first-page":"1","article-title":"Employing ProteoWizard to convert raw mass spectrometry data","volume":"46","author":"Holman","year":"2014","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.jaci.2022.04.006_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-0716-0239-3_2","article-title":"Metabolomics data processing using XCMS","volume":"2104","author":"Domingo-Almenara","year":"2020","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jaci.2022.04.006_bib34","doi-asserted-by":"crossref","first-page":"986048","DOI":"10.1155\/2014\/986048","article-title":"Advanced heat map and clustering analysis using heatmap3","volume":"2014","author":"Zhao","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jaci.2022.04.006_bib35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2222.2008.03198.x","article-title":"Chronic rhinosinusitis with and without nasal polyps is associated with decreased expression of glucocorticoid-induced leucine zipper","volume":"39","author":"Zhang","year":"2009","journal-title":"Clin Exp Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922005413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922005413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:04:24Z","timestamp":1777475064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674922005413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0091674922005413"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.04.006","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Untargeted metabolomic profiling identifies disease-specific and outcome-related signatures in chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}