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Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study [published online ahead of print February 19, 2022]. Allergy. https:\/\/doi.org\/10.1111\/all.15262.","DOI":"10.1111\/all.15262"},{"key":"10.1016\/j.jaci.2022.04.012_bib131","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1158\/1078-0432.CCR-17-3786","article-title":"Mechanistic insights of an immunological adverse event induced by an anti-KIT antibody drug conjugate and mitigation strategies","volume":"24","author":"L\u2019Italien","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jaci.2022.04.012_bib132","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1056\/NEJMoa1613125","article-title":"KIT inhibition by imatinib in patients with severe refractory asthma","volume":"376","author":"Cahill","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaci.2022.04.012_bib133","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1056\/NEJMe1702653","article-title":"Mast cells and KIT as potential therapeutic targets in severe asthma","volume":"376","author":"Galli","year":"2017","journal-title":"N Engl J Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922005504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674922005504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:35:04Z","timestamp":1758792904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674922005504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":133,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0091674922005504"],"URL":"https:\/\/doi.org\/10.1016\/j.jaci.2022.04.012","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KIT as a master regulator of the mast cell lineage","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaci.2022.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}